Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-14T22:31:39.983Z Has data issue: false hasContentIssue false

Clinico-pathological studies on naturally-occurring bovine fascioliasis in the Sudan

Published online by Cambridge University Press:  05 June 2009

E. M. Haroun
Affiliation:
Department of Pathology, Faculty of Veterinary Science, University of Khartoum, P.O. Box 32, Khartoum North, Sudan
M. F. Hussein
Affiliation:
Department of Pathology, Faculty of Veterinary Science, University of Khartoum, P.O. Box 32, Khartoum North, Sudan

Abstract

An investigation was made of the pathological, haematological and biochemical aspects of naturallyoccurring bovine fascioliasis in the Sudan. 228 animals infected with Fasdola gigantica and 25 non-infected controls were used in the study.

The infected cattle revealed emaciation, typical liver pathology, and, occasionally, lesions in the lung and the pancreas. Analysis of their sera also showed reduced albumin values, increased globulin concentrations and decreased albumin/globulin ratio, in addition to increased arginase activity. The serum iron concentration, on the other hand, was decreased, while the total iron binding capacity increased and the resultant iron saturation values reduced. Haematological findings in the infected animals included reduced erythrocyte counts, decreased haematocrjt values, increased mean corpuscular volumes, eosinophilia and decreased neutrophil, lymphocyte and monocytc counts.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Allcroft, W.M. and Folley, S.J. (1941) Observations on the serum phosphatase of cattle and sheep. Biochemical Journal, 35, 254266.CrossRefGoogle ScholarPubMed
Bitakaramire, P.K. and Bwangamoi, O. (1969) Experimental infection of calves with Fasciola gigantica. Experimental Parasitology, 25, 353357.CrossRefGoogle ScholarPubMed
Boyd, J.W. (1962) The comparative activity of some enzymes in sheep, cattle and rats—normal serum and tissue levels and changes during experimental liver necrosis. Research in Veterinary Science, 3, 256268.CrossRefGoogle Scholar
Brundson, R.V. (1967) Liver fluke Fasciola hepatica in sheep and cattle in New Zealand and its control. New Zealand Veterinary Journal, 15, 923.Google Scholar
Campbell, E.A. (1957) The use of paper clectrophoresis as an aid to diagnosis. Journal of Comparative Pathology, 67, 345353.CrossRefGoogle Scholar
Coyle, T.J. (1958) Experiments in the diagnosis and treatment of fascioliasis in Uganda cattle. Bulletin of the Epizootic Diseases of Africa, 6, 255272.Google Scholar
Coyle, T.J. (1961) The epidemiology of Fasciola gigantica in cattle in Uganda protectorate. Thesis, Royal College of Veterinary Surgeons.Google Scholar
Cornelius, C.E., Bishop, J., Switzer, J. and Rhode, E.A. (1959) Serum and tissue transaminiase activities in domestic animals. Cornell Veterinarian, 49, 116126.Google ScholarPubMed
Cornelius, C.E. and Freedland, R.A. (1962) The determination of arginase activity in serum by means of gel filtration. Cornell Veterinarian, 52, 344350.Google ScholarPubMed
Cornelius, C.E. (1970) Liver function in: Clinical Biochemistry of domestic animals (ed. Kaneko, J.J. and Cornelius, C.E.). Academic Press: N.Y. and London, pp. 161230.CrossRefGoogle Scholar
Dow, C., Ross, J.G. and Todd, J.R. (1967) The pathology of experimental fascioliasis in calves. Journal of Comparative Pathology, 77, 377385.CrossRefGoogle ScholarPubMed
Dwevidi, S.K., Joski, H.C. and Shivnani, G.A. (1972) Evaluation of liver function tests in Fasciola infection in cattle and buffaloes. Indian Journal of Animal Health, 11, 8184.Google Scholar
Ehrlich, I., Forenbacher, S., Rijavec, M. and Kurelac, B. (1960) Istraziyanja O skunoj metiljavostir I. nekim klinickim i biokemijskim promjenama kod alkutne metiljavoski goveda. (Summary in Helminthological Abstracts 30 (1961)—Abstract No. 708).Google Scholar
Furmaga, S. and Gundlach, J.L. (1967) Parasitologic and haematologic investigations in the course of experimental fascioliasis in sheep. Acta parasitologica, polonica 14, 313325.Google Scholar
Gardiner, M.R. (1965) Mineral metabolism in sheep lupinosis. I. Iron and cobalt. Journal of Comparative Pathology, 62, 287291.Google Scholar
Garner, M. (1971) Role of diet in bovine and ovine fascioliasis caused by Fasciola gigantica. Bulletin o the Epizootic Diseases of Africa, 19, 4560.Google Scholar
Guralp, N., Ozcan, C. and Simms, B.T. (1964) Fasciola gigantica and fascioliasis in Turkey. American Journal of Veterinary Research, 25, 196210.Google Scholar
Hammond, J.A. and Sewell, M.M.H. (1974) The pathogenic effect of experimental infections with Fasciola gigantica in cattle. British Veterinary Journal, 130, 453465.CrossRefGoogle ScholarPubMed
Haroun, E.M. (1975) Studies on bovine fascioliasis in the Sudan with particular reference to the White Nile Province. Thesis, University of Kliartoum.Google Scholar
Holmes, P.H., Dargie, J.D., Maclean, J.M. and Mulligan, W. (1963) Albumin and globulin turn-over in chronic ovine fascioliasis (Correspondence). Veterinary Record, 83, 227228.CrossRefGoogle Scholar
Hussein, M.F. and Haroun, E.M. (1975) Pulmonary and Pancreatic fascioliasis in Sudanese cattle. British Veterinary Journal, (in press).Google Scholar
Karib, E.A. (1962) Fascioliasis in cattle and sheep in the Sudan. Bulletin Office International des Epizootics, 58, 337346.Google Scholar
Keck, G. and Supperer, R. (1967) The changes in the bile ducts in chronic bovine fascioliasis. Veterinary Medical Review (Bayer–Leverkusen), 322329.Google Scholar
Kind, P.R.N. and King, E.J. (1954) quoted in: Practical clinical Biochemistry by Varley, M. (1967) London: William Heinemann Medical Books Ltd.Google Scholar
Laurell, C.B. (1952) Plasma iron and the transport of iron in the organism. Pharmacological Review, 4, 371.Google ScholarPubMed
Malloy, H.T. and Evelyn, K.A. (1937) quoted in: Microanalysis in Medical Biochemistry by Wooton, I.D. (1964). London: J. and A. Churchill.Google Scholar
Morril, D.R. and Shaw, J.N. (1942) Studies of pathology in cattle produced by liver fluke Fasciola hepatica. Veterinary Bulletin, 13, (1943) No. 363.Google Scholar
Noguchi, I., Kinsowa, T., Sugiura, K. and Komine, S. (1958) Studies on liver function tests on sheep infected with liver fluke (English Summary in Helminthological Abstracts, 29, (1960) No. 2246).Google Scholar
Planas, J. and De Castro, S. (1960) Serum iron and total iron binding capacity in certain mammals. Nature London, 187, 11261127.CrossRefGoogle ScholarPubMed
Ramsay, W.N.M. (1958) Advances in Clinical Chemistry (eds Sobotka, H. and Stewart, C.P.) Academic Press: New York.Google Scholar
Reitman, S. and Frankel, S. (1957) A colorometric method for the determination of serum glutamic oxaloacctic and glutamic pyruvic transaminascs. American Journal of Clinical Pathology, 28, 5663.CrossRefGoogle Scholar
Roberts, H.E. (1968) Observations on experimental acute fascioliasis in sheep. British Veterinary Journal, 124, 433449.CrossRefGoogle ScholarPubMed
Ross, J.G., Todd, J.R. and Dow, C. (1966) Single experimental infections of calves with the liver fluk Fasciola hepatica (Linnaeus, 1758). Journal of Comparative Pathology, 76, 6781.CrossRefGoogle Scholar
Ross, J.G., Dow, C. and Todd, J.R. (1967) A study of Fasciola hepatica infections in sheep. Veterinary Record, 80, 543546.CrossRefGoogle ScholarPubMed
Schalm, O.W. (1965) Veterinary Hacmatology 2nd. ed. Bailliere and Cassel Ltd.: London.Google Scholar
Sewel, M.M.H. (1966) The pathogenesis of fascioliasis. Veterinary Record, 78, 98105.CrossRefGoogle Scholar
Sinclair, K.B. (1965) Iron metabolism in ovine fascioliasis. British Veterinary Journal, 121, 451461.CrossRefGoogle ScholarPubMed
Sinclair, K.B. (1966) Pathogenesis of fascioliasis Veterinary Record, 78, 106107.Google Scholar
Sinclair, K.B. (1967) Pathogenesis of Fasdola and other liver flukes. Helmlnthologkal Abstracts, 36, 115134.Google Scholar
Symons, L.E.A. and Boray, J.C. (1967) Anaemia of ovine fascioliasis. Veterinary Record, 81, 130.Google Scholar
Tartour, G., Adam, S.E.I., Obeed, H.M. and Idris, O.F. (1974) Serum iron, total iron binding capacity and bilirubin concentrations in young ruminants fed with Ipomoea camea. Ada Veterl-naria; Beograd, 24, 261268.Google Scholar
Thorpe, E. (1963) Experimental fascioliasis in the albino rat Thesis, University of Glasgow.Google Scholar
Thorpe, E. (1965a) The pathology of experimental fascioliasis in the albino rat. Journal of Comparative Pathology, 75, 3944.CrossRefGoogle Scholar
Thorpe, E. (1965b) Liver damage and the host parasite relationship in experimental fascioliasis in the albino rat. Research in Veterinary Science, 6, 498509.CrossRefGoogle ScholarPubMed
Underwood, E.J. (1962) Trace elements In human and animal nutrition. Academic Press: New York and London.Google Scholar
Urquhart, G.M. (1955) Experimental fascioliasis in the rabbit. Thesis, University of Glasgow.Google Scholar
Varley, H. (1967) Practical clinical biochemistry. William Heinemann Medical Books Ltd.: London.Google Scholar
Weinbren, B.M. and Coyle, T.J. (1960) Uganda Zebu cattle naturally infected with Fasdola gigantlca with special reference to changes in the serum proteins. Journal of Comparative Pathology, 70, 176181.CrossRefGoogle ScholarPubMed
Wilkinson, J.H. (1970) An introduction to diagnostic enzymology. Edward Arnold Publishers Ltd.: London.Google Scholar
Wotton, I.D.P. (1964) Micro-analysis in medical biochemistry. J. and A. Churchill Ltd.: London.Google Scholar