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The effect of Praziquantel on Schistosoma mansoni

Published online by Cambridge University Press:  05 June 2009

G. C. Coles
G. C. Coles
Affiliation:
Imperial Chemical Industries, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire SK10 4TG
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Abstract

3 × 10−6M praziquantel fails to completely paralyse miracidia and cercariae in a short time but they are not infective when maintained in the solution. 3 × 10−5M praziquantel prevents infected snails shedding cercariae but does not kill daughter sporocyts or developing cercariae. As the action of praziquantel on adult worms is not blocked by 10−2M mecamylamine, pempidine or carbachol, but is reduced by calcium deplection, it is suggested that praziquantel may act by permitting calcium influx to muscle cells causing them to contract.

Type
Research Papers
Information
Journal of Helminthology , Volume 53 , Issue 1 , March 1979 , pp. 31 - 33
Copyright
Copyright © Cambridge University Press 1979

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References

REFERENCES

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