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High levels of Schistosoma mansoni infections among schoolchildren in central Sudan one year after treatment with praziquantel

Published online by Cambridge University Press:  08 June 2011

A.M. Ahmed ,
L.A. El Tash ,
E.Y. Mohamed  and
I. Adam
A.M. Ahmed
Affiliation:
Schistosomiasis Research Laboratory, Faculty of Science, University of Khartoum, Sudan
L.A. El Tash
Affiliation:
Health Economic Center Faculty of Economics, University of Khartoum, Sudan
E.Y. Mohamed
Affiliation:
Faculty of Medicine, University of Khartoum, Sudan
I. Adam*
Affiliation:
Faculty of Medicine, University of Khartoum, Sudan
*
*Fax: +249183771211 E-mail: ishagadam@hotmail.com
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Abstract

A longitudinal study was conducted to evaluate the impact of praziquantel (PZQ) for the treatment of Schistosoma mansoni infection among schoolchildren in Al Gunaid in Central Sudan. A cohort of schoolchildren (6–15 years of age) was investigated before and 1 year after treatment with a single dose of PZQ 40 mg/kg. Parasitological examinations for S. mansoni were performed before and after treatment, and prevalence and intensity of infection were analysed. Of 2741 schoolchildren recruited from six elementary schools at baseline, 2521 were successfully traced and re-examined at follow-up, with two complete sets of longitudinal parasitological data on S. mansoni. Boys showed significantly higher prevalence of S. mansoni infection than girls. A single dose of PZQ reduced the overall prevalence of S. mansoni infection by 36.7% (from 59.1 to 37.4%) and the intensity of infection by 41.1% (from 116.7 to 68.7 eggs per gram of stool) 1 year after treatment. The reduction in prevalence was significantly higher among the group of children with heavy infections (by 76.1%, from 6.7 to 1.6%) and among girls (by 54.1%, 42.3 to 19.4%) at 1 year after treatment. Thus, in spite of a significant reduction in the prevalence and intensity of S. mansoni infection 1 year after PZQ treatment, the prevalence of the disease was still high and further research is needed on this topic.

Type
Research Papers
Information
Journal of Helminthology , Volume 86 , Issue 2 , June 2012 , pp. 228 - 232
Copyright
Copyright © Cambridge University Press 2011

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