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Shedding of Angiostrongylus costaricensis larvae in the faeces of Swiss mice experimentally infected with different infective doses

Published online by Cambridge University Press:  24 October 2018

C.C. Hermes ,
E. Benvegnú ,
M.M. Costa ,
R. Rodriguez  and
M.I.B. Vieira Open the ORCID record for M.I.B. Vieira [Opens in a new window]
C.C. Hermes
Affiliation:
Programa de Pós-graduação em Bioexperimentação, Universidade de Passo Fundo - UPF, Campus I, BR 285, Bairro São José. 99052-900 – Passo Fundo, Rio Grande do Sul, Brazil
E. Benvegnú
Affiliation:
Programa de Pós-graduação em Bioexperimentação, Universidade de Passo Fundo - UPF, Campus I, BR 285, Bairro São José. 99052-900 – Passo Fundo, Rio Grande do Sul, Brazil
M.M. Costa
Affiliation:
Programa de Pós-graduação em Bioexperimentação, Universidade de Passo Fundo - UPF, Campus I, BR 285, Bairro São José. 99052-900 – Passo Fundo, Rio Grande do Sul, Brazil
R. Rodriguez
Affiliation:
Faculdade de Medicina, Universidade de Passo Fundo – UPF; Instituto de Patologia de Passo Fundo, Rio Grande do Sul, Brazil
M.I.B. Vieira*
Affiliation:
Programa de Pós-graduação em Bioexperimentação, Universidade de Passo Fundo - UPF, Campus I, BR 285, Bairro São José. 99052-900 – Passo Fundo, Rio Grande do Sul, Brazil
*
Author for correspondence: M.I.B. Vieira, E-mail: marisabel@upf.br
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Abstract

Abdominal angiostrongyliasis is an endemic zoonosis in southern Brazil caused by the nematode Angiostrongylus costaricensis, which uses terrestrial molluscs as intermediate hosts and wild rodents as final hosts. Humans can be infected by ingesting infectious A. costaricensis larvae. To date, correlations between shedding of first-stage larvae (L1) and different infective doses of third-stage larvae (L3) have not been elucidated. The aim of this study was to assess L1 faecal shedding levels in Swiss mice experimentally infected with different doses of A. costaricensis L3 and to determine whether infective doses are related to mortality. Thirty-two male Swiss mice were divided evenly into a non-infected control (NI-Con); low-dose infection (LD-Inf); medium-dose infection (MD-Inf) and high-dose infection (HD-Inf) groups infected with 0, 5, 15 and 30 A. costaricensis L3, respectively. Faecal samples were collected from each animal, starting at day 20 post infection. HD-Inf mice had greater faecal L1 shedding levels than LD-Inf mice, but not a significantly shortened survival. In conclusion, infective doses of A. costaricensis L3 affect L1 shedding levels without altering mortality in Swiss mice.

Keywords

abdominal angiostrongyliasisfaecal shedding of larvaeinfective doses
Type
Research Paper
Information
Journal of Helminthology , Volume 94 , 2020 , e3
Copyright
Copyright © Cambridge University Press 2018 

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References

Azevedo, GV et al. (2010) Elimination of Angiostrongylus costaricensis larvae in feces from experimentally infected Swiss mice: circadian rhythm and correlation with survival. Parasitology Research 108, 537–540.Google Scholar
Bender, AL et al. (2003) Ovos e órgãos reprodutores de fêmeas de Angiostrongylus costaricensis são reconhecidos mais intensamente por soros humanos de fase aguda na angiostrongilíase abdominal. Revista da Sociedade Brasileira de Medicina Tropical 36, 449–454.Google Scholar
Canali, C, Goulart, AH and Graeff-Teixeira, C (1998) Study on the elimination of Angiostrongylus costaricensis first stage larvae in the experimental infection of Swiss mice. Memórias do Instituto Oswaldo Cruz 93, 269–272.Google Scholar
Gandon, S et al. (2008) Host–parasite coevolution and patterns of adaptation across time and space. Journal of Biology 21, 1861–1866.Google Scholar
Geiger, SM et al. (2003) Angiostrongylus costaricensis infection in C57BL/6 mice: MHC-II deficiency results in increased larval elimination but unaltered mortality. Parasitology Research 90, 415–420.Google Scholar
Graeff-Teixeira, C, Camillo-Coura, L and Lenzi, HL (1991) Clinical and epidemilogical aspects of abdominal angiostrongyliasis in Southern Brazil. Revista do Instituto Médico Tropical de São Paulo 33, 373–378.Google Scholar
Ishih, A and Nishimura, M (1997) Differential responses of SM/J and A/J mice to experimental Angiostrongylus costaricensis infection. Journal of Parasitology 27, 141l–1414.Google Scholar
Ishih, AI and Sano, M (1989) Strain dependent differences in susceptibility of mice to experimental Angiostrongylus costaricensis infection. Journal of Helminthology 63, 302–306.Google Scholar
Ishih, A et al. (2000) Genetic analysis of mortality in murine angiostrongyliasis costaricensis using SMXA recombinant inbred mouse strains. Parasitology International 49, 335–338.Google Scholar
Morera, P (1985) Abdominal angiostrongyliasis: a problem of public health. Parasitology 1, 173–175.Google Scholar
Morera, P and Céspedes, R (1971) Angiostrongylus costaricensis n. sp. (Nematoda: Metastrongyloidea), a new lungworm occurring in man in Costa Rica. Revista de Biología Tropical 18, 17.Google Scholar
Mota, EM and Lenzi, EMM (2005) Angiostrongylus costaricensis: complete redescription of the migratory pathways based on experimental Sigmodon hispidus infection. Memórias do Instituto Oswaldo Cruz 100, 407–420.Google Scholar
Rodriguez, R et al. (2008) Abdominal angiostrongyliasis: report of two cases with different clinical presentations. Revista do Instituto Médico Tropical de São Paulo 50, 339–341.Google Scholar
Tesh, RB et al. (1973). Angiostrongylus costaricensis in Panama. Prevalence and pathological findings in wild rodents infected with the parasite. The American Journal of Tropical Medicine and Hygiene 27, 348–356.Google Scholar