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Antifilarial activity of intravenous suramin and oral diethylcarbamazine citrate on subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata

Published online by Cambridge University Press:  05 June 2009

J. W. Mak ,
P. L. W. Lam ,
M. F. Choong  and
K. Suresh
J. W. Mak
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
P. L. W. Lam
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
M. F. Choong
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
K. Suresh
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
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Abstract

The known filaricides, suramin and diethylcarbamazine citrate, were tested against subperiodic Brugia malayi infection in the leaf-monkey, Presbytis cristata. As expected, intravenous suramin at 10 mg/kg daily × 5 days or 17 mg/kg weekly × 5 weeks, did not show any microfilaricidal activity, but substantially reduced the recovery of live adult worms to 50·6% and 13·6% of controls respectively. Oral diethylcarbamazine citrate at 6 mg/kg daily × 6 or 10 days reduced final microfilarial counts to 30% of initial counts four weeks post-treatment and adult worm recovery was reduced to 4·5% and 0% of controls respectively. Although the antifilarial activity of these drugs against the infection in this non-human primate model appears to be similar to that seen in man, these results have to be confirmed using larger groups of animals.

Keywords

Brugia malayiPresbytis cristatasuramindiethylcarbamazine citratechemotherapy
Type
Research Article
Information
Journal of Helminthology , Volume 64 , Issue 2 , June 1990 , pp. 96 - 99
Copyright
Copyright © Cambridge University Press 1990

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References

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