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Comparative efficacy of flubendazole and mebendazole on encysted larvae of Trichinella spiralis (USA strain) in the diaphragm of mice and rats

Published online by Cambridge University Press:  05 June 2009

Jun Maki  and
Toshio Yanagisawa
Jun Maki
Affiliation:
Department of Parasitology, Kitasato University School of Medicine, Sagamihara, 228 Japan
Toshio Yanagisawa
Affiliation:
Department of Parasitology, Kitasato University School of Medicine, Sagamihara, 228 Japan
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Abstract

Comparative efficacy of mebendazole and flubendazole, a p−fluor analogue of mebendazole against the encysted larvae of Trichinella spiralis (USA strain) in the diaphragm of mice and rats were studied in order to provide a better understanding of the structure-activity relationship within the benzimidazole series. Drugs given 10–100 mg/kg/day for 3 consecutive days (35–37 days post-infection) or at 300 mg/kg, 35 days post infection were significantly effective in decreasing early encysted larvae in mice. No significant differences in effectiveness against the early encysted larvae could be observed between the drugs under the present experimental conditions. Mebendazole was found to be more effective that flubendazole in decreasing old encysted larvae in mice treated 70–72 days post-infection based on a comparative study of their ED50 values. When rats were given the drugs at the dose of 10 mg/kg/day for 3 consecutive days, mebendazole was significantly effective against both early and old encysted larvae while flubendazole was not.

Keywords

Trichinella spiralismebendazoleflubendazolemouseratencysted larvae
Type
Research Papers
Information
Journal of Helminthology , Volume 62 , Issue 1 , March 1988 , pp. 35 - 39
Copyright
Copyright © Cambridge University Press 1988

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References

REFERENCES

Ambu, S. & Mak, J. W. (1981)The effects of mebendazole and flubendazole on Angiostrongylus malaysiensis infection in rats. Southeast Asian Journal of Tropical Medicine and Public Health, 12, 228–230.Google Scholar
Campbell, W. C. & Denham, D. A. (1983)Chemotherapy. In: Trichinella and Trichinosis (editor Campbell, W. C.), pp. 335–366. Plenum Press: New York.Google Scholar
Denollin, S., Borgers, M., Vanparijs, O. & Van Den Bossche, H.(1974) Effects of mebendazole on the encysted phase of Trichinella spiralis in the rat: an electron-microscope study. Parasitology, 69, 55–62.Google Scholar
Fernando, S. S. E. & Denham, D. A. (1976)The effects of mebendazole and fenbendazole on Trichinella spiralis in mice. Journal of Parasitology, 62, 874–876.CrossRefGoogle ScholarPubMed
Maki, J., Nakajima, M. & Yanagisawa, T.(1983) Effects of flubendazole and mebendazole on encysted larvae of Trichinella spiralis (USA strain). In Abstracts, 25th Annual Meeting of Japanese Society of Tropical Medicine, p. 20.Google Scholar
Maki, J. & Yanagisawa, T.(1983) A comparison of the effects of flubendazole and thiabendazole on the larvae of Angiostrongylus cantonensis, Trichinella spiralis, Diphyllobothrium erinacei and Hymenolepis nana in mice. Parasitology, 87, 525–531.Google Scholar
Maki, J. & Yanagisawa, T.(1985) Anthelmintic effects of bithionol, paromomycin sulphate, flubendazole and mebendazole on mature and immature Hymenolepis nana in mice. Journal of Helminthology, 59, 211–216.CrossRefGoogle ScholarPubMed
McCracken, R. O. (1978)Efficacy of mebendazole and albendazole against Trichinella spiralis in mice. Journal of Parasitology, 64, 214–219.CrossRefGoogle ScholarPubMed
McCraken, R. O. & Taylor, D. D. (1980)Mebendazole therapy of parenteral trichinellosis. Science, 207, 1220–1222.CrossRefGoogle Scholar
McCracken, R. O., Garcia, A. & Robins, H. G. (1982)Mebendazole therapy of enteral trichinellosis. Journal of Parasitology, 68, 259–262.CrossRefGoogle ScholarPubMed
Takada, N. & Tatefuji, N.(1982) The effects of benzimidazoles, especially mebendazole on Iwasaki-strain trichinellosis in mice. Program and Summary of Sino-Japanese Seminar on Parasitic Zoonoses, p. 136–140.Google Scholar
Thienpont, D., Vanparijs, O., Niemegeers, C. & Marsboom, R.(1978) Biological and pharmacological properties of flubendazole. Arzneimittel-Forschung, 28, 605–612.Google Scholar
Van Den Bossche, H., Rochette, F. & Hörig, C.(1982) Mebendazole and related anthelmintics. Advances in Pharmacology and Chemotherapy, 19, 67–127.CrossRefGoogle ScholarPubMed
Vanparijs, O., Hermans, L. & Thienpont, D.(1979) Anthelmintic activity of flubendazole against Trichinella spiralis in rats. Veterinary Parasitology, 5, 237–242.CrossRefGoogle Scholar