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Continuous feed medication with thiabendazole for the removal of Hymenolepis nana, Syphacia obvelata and Aspiculuris tetraptera in naturally infected mice

Published online by Cambridge University Press:  05 June 2009

L. F. Taffs
L. F. Taffs
Affiliation:
National Institute for Medical Research, Mill Hill, London, NW1 7AA
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Abstract

A medicated diet containing 0.3% thiabendazole fed continuously to 26 mice for 7 days removed 9 out of 11 (82%) Hymenolepis nana, (one tapeworm remaining in each of two mice), 17 out of 17 (100%) Syphacia obvelata and 8 out of 8 (100%) Aspiculuris tetraptera infections. By contrast in 26 non-treated mice 9 out of 10 Hymenolepis, 17 out of 18 Syphacia and 8 out of 8 Aspiculuris infections persisted through the 7 day treatment period, and at post mortem examination 38 Hymenolepsis, 1,562 Syphacia and 4,911 Aspiculuris worms were recovered. In a second experiment 100% removal of 23 Hymenolepis and 20 Syphacia infections was obtained after 14 days medication of 38 mice. High activity against both roundyvorms and tapeworms of mice was thus obtained using one single drug. Some unexplained deaths amongst inbred strain C3H/Hef Nimr mice occurred within seven day's of the continuous medication.

Type
Research Article
Information
Journal of Helminthology , Volume 49 , Issue 3 , September 1975 , pp. 173 - 177
Copyright
Copyright © Cambridge University Press 1975

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References

REFERENCE

Campbell, W.C. (1961) Effect of thiabendazole upon infections of Trichinella splralis in mice, and upon certain other helminthiases. Journal of Parasitology, 47 (Section 2), 37.Google Scholar
Eaton, G.J. (1972) Intestinal helminths in inbred strains of mice Laboratory Animal Science, 22, 850–853.Google Scholar
Graessle, O.E., Stoerk, H.C., Lehman, E.G., Kelley, K.L. and Robinson, H.J. (1964) Toxicity and pharmacologic properties of thiabendazole. Federation Proceedings, 23, Abstract 1724, p.388.Google Scholar
Griffiths, H.J. (1971) Some common parasites of small laboratory animals. Laboratory Animals, 5, 123–135.Google Scholar
Habermann, R.T. and Williams, F.P. Jr. (1958) The identification and control of helminths in laboratory animals. Journal of the National Cancer Institute, 20, 979–1009.Google ScholarPubMed
King, VERA M. and Cosgrove, G.E. (1963) Intestinal helminths in various strains of laboratory mice. Laboratory Animal Care, 13, 46–48.Google ScholarPubMed
Lambert, R.A. (1969) Parasitology: identification of helmintlis, p. 9London: Butterworths.Google Scholar
Owen, D. (1972) Common parasites of laboratory rodents and lagomorplis. London: HMSO.Google Scholar
Taffs, L.F. and Davidson, J.B. (1967) Low-level thiabendazole in the control of worm parasites in pigs. Veterinary Record, 81, 426–435.Google Scholar