Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-14T22:05:09.348Z Has data issue: false hasContentIssue false

The effect of gamma radiation on cercariae of Schistosoma mansoni*

Published online by Cambridge University Press:  05 June 2009

G. Webbe
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St. Albans

Abstract

Studies were made of the fate of irradiated cercariae of Schistosoma mansoni, during their migration as schistosomula in the definitive host, by direct recovery of intact schistosomula from the skin and lungs and of adult worms from the liver of infected mice. Gamma radiation (6000 r) inhibited the migration and maturation of S. mansoni schistosomula to the adult stage. Penetration of irradiated cercariae into host skin proceeded normally and the first site of damage was in the lungs, but the majority of irradiated schistosomula were probably destroyed in the liver. The efiects of gamma radiation compared with those of ultra-violet radiation on cercariae of S. mansoni are discussed.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Clegg, J.A. (1965) In vitro cultivation of Schistosonia mansoni. Experimental Parasitology, 16, 133147.CrossRefGoogle ScholarPubMed
Clegg, J.A. and Smithers, S.R. (1968) Death of schistosome cercariae during penetration of the skin. II. Penetration of mamalian skin by Schistosoma mansoni. Parasitology, 58,111128.CrossRefGoogle Scholar
Erickson, D.G. and Caldwell, W.L. (1965) Acquired resistance in mice and rats after exposure to gamma-irradiated cercariae. American Journal of Tropical Medicine and Hygiene, 14, 566573.CrossRefGoogle Scholar
Erickson, D.G. (1965) The fate of gamma-irradiated Schistosoma mansoni cercariae in mice. American Journal of Tropical Medicine and Hygiene, 14, 574578.CrossRefGoogle Scholar
Ghandour, A.M. and Webbe, G. (1975) The effect of ultra-violet irradiation on cercariae of Schistosoma mansoni and Schistosoma haematobium. Journal of Helminthology, 49, 153159.Google Scholar
Hsu, H.F. and Hsu, S.Y.L. (1963) Histopathology in albino mice and rhesus monkeys infected with irradiated cercariae of Schistosoma japonicum. Zeltschrift für Tropenmedizin und Parasitologie, 14, 240261.Google Scholar
Lichtenberg, F. and Sadun, E.H. (1963) Parasite migration and host reaction in mice exposed to irradiated cercariae of Schistosoma mansoni. Experimental Parasitology, 13, 256265.CrossRefGoogle Scholar
Radke, M.G. and Sadun, E.H. (1963) Resistance produced in mice by exposure to irradiated Schistosoma mansoni cercariae. Experimental Parasitology, 13,134142.CrossRefGoogle ScholarPubMed
Smithers, S.R. and Terry, R.J. (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology, 55, 695700.CrossRefGoogle ScholarPubMed
Villella, J.B., Gomberg, H.J. and Gould, S.E. (1961) Immunisation to Schistosoma mansoni in mice inoculated with irradiated carcariae. Science, New York, 134,10731074.CrossRefGoogle Scholar
Villella, J.B. and Weinbren, M.P. (1965) Abnormalities in the adult Schistosoma mansoni developed from gamma-irradiated cercariae. Journal of Parasitology, 51, 42.Google Scholar