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The effect of sublethal concentrations of the molluscicide niclosamide on the infectivity of Schistosoma mansoni cercariae*

Published online by Cambridge University Press:  05 June 2009

A. M. Ghandour
A. M. Ghandour
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St. Albans, Herts
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Abstract

Experiments were conducted to assess the effect of sublethal concentrations of niclosamide on the infectivity of Schistosoma mansoni cercariae. Exposure of cercariae to 0.02 mg/1 and 0.05 mg/1 of niclosamide, respectively, for only two hours increased their mortality during penetration of mammalian host skin. The observed increase in mortality in the skin resulted in a consequent reduction of adult worm recovery from the liver and mesenteric veins of animals infected with the treated cercariae.

Type
Research papers
Information
Journal of Helminthology , Volume 49 , Issue 4 , December 1975 , pp. 245 - 250
Copyright
Copyright © Cambridge University Press 1975

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References

REFERENCE

Atkins, W.R.G. (1947) A suggested repellent for schistosome cercariae. Journal of Parasitology, 45, 468.Google Scholar
Austin, F.G. and Frappaolo, P.J. (1973) Schistosoma mansoni: chemoprophylaxis studies with anti-penetration compounds. American Journal of Tropical Medicine and Hygiene, 22, 743–747.CrossRefGoogle Scholar
Azevedo, J.F. and Pequito, M.M. (1961) Molluscicide and ccrcaricide effects of Bayer 73 incorporated in soap. Garcia De Orta, 9, 201–205.Google Scholar
Bruaux, P. and Gillet, J. (1961) Laboratory trials of the new molluscicidcs Bayer 73 and ICI 24223. Bulletin of the World Health Organization, 25, 509–517.Google Scholar
Campbell, W.C. and Cuckler, A.C. (1961) The prophylactic effect of topically applied ccdarwood oil on infection with Schistosoma mansoni in mice. American Journal of Tropical Medicine and Hygiene, 10, 712–715.CrossRefGoogle ScholarPubMed
Clegg, J.A. and Smithers, S.R. (1968) Death of schistosome cercariae during penetration of the skin. 11. Penetration of mammalian skin by Schistosoma mansoni. Parasitology, 58, 111–128.CrossRefGoogle Scholar
Frick, L.P. and Hillyer, G.V. (1966) The influence of pH and temperature on the cercaricidal activity of chlorine. Military Medicine, 131, 372–378.Google Scholar
Fripp, P.J., Armstrong, F.A. and Jaskulla, E. (1973) The efficacy of a hexachlorohenc skin cleanser as a cercariae repellent. South African Medical Journal, 47, 526–527.Google Scholar
Ghandour, A.M. and Webbe, G. (1973) A study of the death of Schistosoma mansoni cercariae during penetration of mammalian skin: the effects of ages of the cercariae and the host. International Journal of Parasitology, 3, 789–794.Google Scholar
Gönnert, R. (1961) Results of laboratory and field trials with the molluscicide Bayer 73. Bulletin of the World Health Organization, 25, 483–501.Google Scholar
Hira, P.R. and Webbe, G. (1972) The effect of sublethal concentrations of the molluscicide Triphenyl lead acetate on Biomphalaria glabrata (Say) and on the development of Schistosoma mansoni in the snail. Journal of Hclminthology, 46, 11–26.Google Scholar
Hunter, G.W., Ritchie, L.S., Tanabe, H., Nagano, K., Pan, C. and Yokogawa, M. (1952) Studies on schistosomiasis. V. Testing protective ointments against schistosomiasis by using schistosome dermatitis-producing cercariae. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46, 201–206Google Scholar
Hunter, G.W., Ritchie, L.S., Lin, S., Pan, C. and Tanabe, H. (1956) Immunological studies. I. Experiments with bird and human schistosomes in small mammals. Experimental Parasitology, 5, 551–559.Google Scholar
Ingalls, J.W. (1946) The control of schistosomiasis japonica. III. Studies on the longevity of cercariae of Schistosoma japonicum in saline solutions. Journal of Parasitology, 32, 521–524.Google Scholar
Krakower, C.A. (1940) Some observations on the effects of physical and chemical agents on the cercariae of Schistosoma mansoni. Puerto Rico Journal of Public Health and Tropical Medicine, 16, 26–44.Google Scholar
Kuntz, R.E. and Stirewalt, M.A. (1946) Effects of DDT on cercariae of Schistosoma mansoni. Journal of Parasitology, 32, 529–538.CrossRefGoogle ScholarPubMed
Lewert, R.M., Hopkins, D.R. and Mandlowitz, S. (1966) The role of calcium and magnesium in invasiveness of schistosome cercariae. American Journal of Tropical Medicine and Hygiene, 15, 314–323.Google Scholar
Massoud, J. and Webbe, G. (1969) The effect of sublethal doses of the molluscicide N-tritylmorpholinc on the development of Schistosoma mansoni in Biomphalaria glabrata (Say). Journal of Helminthology, 43, 99–110.Google Scholar
Moon, A.P. and Hunter, G.W. (1955) Studies on schistosomiasis. VIII. Failure of copper oleate to afford complete protection to mice against Schistosoma mansoni. Experimental Parasitology, 4, 165–171.Google Scholar
Olivier, J., Biggui, N. and Rivea, L.J. (1945) The effect of chlorine on the motility and infectivity of the cercariae of Schistosoma mansoni. Puerto Rican Journal of Public Health and Tropical Medicin, 220, 357–360.Google Scholar
Smtthers, S.R. and Terry, R.J. (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology, 55, 695–700.CrossRefGoogle Scholar
Stirewalt, M.A. and Fregeau, W.A. (1965) Effect of selected experimental conditions on penetration and maturation of Schistosoma mansoni in mice. I. Environmental. Experimental Parasitology, 17, 168–179.Google Scholar
Sturrockl, R.F. (1966) The influence of temperature on the biology of Biomphalaria pfeifferi (Kraus): an intermediate host of Schistosoma mansoni. Annals of Tropical Medicine and Parasitology, 60, 100–105.Google Scholar
Webbe, G. (1961) Laboratory and field trials of a new molluscicide, Bayer 73, in Tanganyika. Bulletin of the World Health Organization, 25, 525–531.Google Scholar
WORLD HEALTH ORGANISATION (1965) Molluscicide screening and evaluation. Bulletin of the World Health Organisation. 33, 567–581.Google Scholar