Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-27T10:06:38.211Z Has data issue: false hasContentIssue false
  • English
  • Français

The efficacy of levamisole administered orally or parenterally against Heligmosomoides polygyrus in mice

Published online by Cambridge University Press:  05 June 2009

D. M. Chimwani  and
D. P. Britt
D. M. Chimwani
Affiliation:
Department of Veterinary Parasitologycor1corresp
2
, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
D. P. Britt
Affiliation:
Department of Veterinary Parasitologycor1corresp
2
, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
Get access Rights & Permissions [Opens in a new window]

Abstract

Albion mice (Balb c/nut) experimentally infected with Heligmosomoides polygyrus were treated with levamisole hydrochloride (‘Nemicide’—ICI Pharmaceutical PLC) by oral drenching or subcutaneous injection at 5, 10 and 20 mg kg −1. Faecal egg counts monitored for two three days after dosing and post-mortem worm counts were used to assess the efficacy of these treatments. The lowest dose rate gave poor clearance of adult worms but at 10 and 20 mg kg−1, 91 and 96% reduction in worm burden were achieved. Reduction in post-dosing faecal egg counts were variable. Neither method of administration offered particular advantage in terms of efficacy. Faecal egg count data gave inconsistent differences and at necropsy, worm counts were lower in mice dosed orally but not significantly so.

Keywords

Heligmosomoides Polygyruslevamisolemouse
Type
Research Papers
Information
Journal of Helminthology , Volume 60 , Issue 2 , June 1986 , pp. 99 - 104
Copyright
Copyright © Cambridge University Press 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bogan, J. A., Marriner, S. E. & Galbraith, C. A. (1982) Pharmacokinetics of levamisole in sheep. Research in Veterinary Science, 32, 124–126.CrossRefGoogle ScholarPubMed
Brody, G. & Elward, T. E. (1971) Comparative activity of 29 known anthelmintics under standardized drug-diet and gavage medication regimens against four helminth species in mice. Journal of Parasitology, 57, 1068–1077.Google ScholarPubMed
Broome, A. W. J. & Lewis, J. A. (1974) Activity of levamisole against development stages of Dictyocaulus viviparus in experimentally infected calves. Veterinary Record, 94, 563–566.Google Scholar
Jacobs, D. C., Lean, I. J. & Oakley, G. A. (1977) Levamisole: efficacy against Trichuris suis. Veterinary Record, 100, 49.CrossRefGoogle ScholarPubMed
Oakley, G. A. (1977) Efficacy of levamisole hydrochloride administered subcutaneousty against Oesophagostomum dentatum infection in pigs. Veterinary Record, 100, 310–312.CrossRefGoogle ScholarPubMed
Roberson, E. L. (1982) Antinematodal drugs. In: Veterinary Pharmacology and Therapeutics 5th Edition (editros, Booth, N. H. & MacDonald, L. E.) pp. 803–851. Iowa State University Press: Ames, USA.Google Scholar
Ronald, N. C., Bell, R. R. & Craig, T. M. (1977) Evaluation of less than recommended dosages of levamisole phosphate for the treatment of gastro-intestinal nematodes of cattle, Journal of the American Veterinary Medical Association, 170, 317–319.Google Scholar
Sayles, P. C. & Jacobson, R. H. (1983) Effects of various anthelmintics on larval Stages of Nematospiroides dubius (Nematoda). Journal of Parasitology, 69, 1079–1083.CrossRefGoogle ScholarPubMed