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The efficacy of levamisole administered orally or parenterally against Heligmosomoides polygyrus in mice

Published online by Cambridge University Press:  05 June 2009

D. M. Chimwani  and
D. P. Britt
D. M. Chimwani
Affiliation:
Department of Veterinary Parasitologycor1corresp
2
, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
D. P. Britt
Affiliation:
Department of Veterinary Parasitologycor1corresp
2
, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
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Abstract

Albion mice (Balb c/nut) experimentally infected with Heligmosomoides polygyrus were treated with levamisole hydrochloride (‘Nemicide’—ICI Pharmaceutical PLC) by oral drenching or subcutaneous injection at 5, 10 and 20 mg kg −1. Faecal egg counts monitored for two three days after dosing and post-mortem worm counts were used to assess the efficacy of these treatments. The lowest dose rate gave poor clearance of adult worms but at 10 and 20 mg kg−1, 91 and 96% reduction in worm burden were achieved. Reduction in post-dosing faecal egg counts were variable. Neither method of administration offered particular advantage in terms of efficacy. Faecal egg count data gave inconsistent differences and at necropsy, worm counts were lower in mice dosed orally but not significantly so.

Keywords

Heligmosomoides Polygyruslevamisolemouse
Type
Research Papers
Information
Journal of Helminthology , Volume 60 , Issue 2 , June 1986 , pp. 99 - 104
Copyright
Copyright © Cambridge University Press 1986

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References

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