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Extraintestinal migration of Pharyngostomum cordatum metacercariae in experimental rodents

Published online by Cambridge University Press:  12 April 2024

E.H. Shin ,
J.Y. Chai  and
S.H. Lee
E.H. Shin
Affiliation:
Department of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, Korea
S.H. Lee
Affiliation:
Department of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, Korea
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Abstract

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Extraintestinal migration patterns of Pharyngostomum cordatum (Digenea: Neodiplostomidae) were studied in experimental rodents such as mice, rats, and hamsters. When metacercariae isolated from grass snakes were infected orally to rodents, they penetrated the intestinal wall at days 2–3 post-infection (p.i.) and were discovered mainly in the diaphragm, intercostal muscles, and vital organ such as the lungs at days 7–28 p.i., without morphological changes. Interestingly, from several rodents which died suddenly at days 2–9 p.i., small to considerable numbers of metacercariae were found, not only in the lungs, but also in the heart and brain. Within the tissues, worms were freely motile until day 7 p.i., but later they were surrounded by host cells, and finally tissue cysts were formed. When metacercariae harvested from the snakes and intercostal muscles of rodents were infected orally to cats, they developed into adult flukes in the small intestine. The results show that P. cordatum undergoes considerable extraintestinal migration including the vital organs of its rodent hosts.

Type
Research Article
Information
Journal of Helminthology , Volume 75 , Issue 3 , September 2001 , pp. 285 - 290
Copyright
Copyright © Cambridge University Press 2001

References

Beaver, P.C., Little, M.D., Tucker, C.F. & Reed, R.J. (1977) Mesocercaria in the skin of man in Louisiana. American Journal of Tropical Medicine and Hygiene 26, 422–426.10.4269/ajtmh.1977.26.422CrossRefGoogle ScholarPubMed
Bosma, N.J. (1934) The life history of the trematode Alaria mustelae, Bosma, 1931. Transactions of the American Microscopical Society 53, 116–153.CrossRefGoogle Scholar
Chai, J.Y., Sohn, W.M., Chung, H.-L., Hong, S.T. & Lee, S.H. (1990) Metacercariae of Pharyngostomum cordatum found from the European grass snake, Rhabdophis tigrina, and its experimental infection to cats. Korean Journal of Parasitology 28, 175–181.CrossRefGoogle ScholarPubMed
Fernandes, B.J., Cooper, J.D., Cullen, J.B., Freeman, R.S., Ritchie, A.C., Scott, A.A. & Stuart, P.F. (1976) Systemic infection with Alaria americana (Trematoda). Canadian Medical Association Journal 115, 1111–1114.Google ScholarPubMed
Freeman, R.S., Stuart, P.F., Cullen, J.B., Ritchie, A.C., Mildon, A., Fernandes, B.J. & Bonin, R. (1976) Fatal human infection with mesocercariae of the trematode Alaria americana . American Journal of Tropical Medicine and Hygiene 25, 803–807.10.4269/ajtmh.1976.25.803CrossRefGoogle ScholarPubMed
Hong, S.T., Cho, T.K., Hong, S.J., Chai, J.Y., Lee, S.H. & Seo, B.S. (1984) Fifteen human cases of Fibricola seoulensis infection in Korea. Korean Journal of Parasitology 22, 61–65.10.3347/kjp.1984.22.1.61CrossRefGoogle ScholarPubMed
Hong, S.T., Chai, J.Y. & Lee, S.H. (1986) Ten human cases of Fibricola seoulensis and mixed one with Stellantchasmus and Metagonimus . Korean Journal of Parasitology 24, 95–97.10.3347/kjp.1986.24.1.95CrossRefGoogle ScholarPubMed
Kajiyama, M. & Nakamoto, M. (1982) Studies on Pharyngostomum cordatum (Diesing, 1850) in Japan. Yamaguchi Journal of Veterinary Medicine 9, 51–58.Google Scholar
Kook, J., Nawa, Y., Lee, S.H. & Chai, J.Y. (1998) Pathogenicity and lethality of a minute intestinal fluke, Neodiplostomum seoulense, to various strains of mice. Journal of Parasitology 84, 1178–1183.10.2307/3284669CrossRefGoogle ScholarPubMed
Kramer, M.H., Eberhard, M.L. & Blankenberg, T.A. (1996) Respiratory symptoms and subcutaneous granuloma caused by mesocercariae: a case report. American Journal of Tropical Medicine and Hygiene 55, 447–448.CrossRefGoogle ScholarPubMed
Kurimoto, H. (1976) Study on the life history of Pharyngostomum cordatum (Diesing, 1850) I. The second intermediate host in Japan and experimental infection to the final host. Japanese Journal of Parasitology 25, 241–246.Google Scholar
McDonald, H.R., Kazakos, K.R., Schatz, H. & Johnson, R.N. (1994) Two cases of intraocular infection with Alaria mesocercariae (Trematoda). American Journal of Ophthalmology 117, 447–455.10.1016/S0002-9394(14)70003-0CrossRefGoogle Scholar
Ooi, H.K., Kamiya, M., Kudo, T., Hashimoto, A. & Kitazawa, K. (1984) Diplostomulum of Pharyngostomum cordatum in the muscle of a raccoon dog Nyctereutes procyonoides . Japanese Journal of Veterinary Science 46, 409–412.Google ScholarPubMed
Seo, B.S. (1990) Fibricola seoulensis, Seo, Rim and Lee, 1964 (Trematoda) and fibricoliasis in man. Seoul Journal of Medicine 31, 61–96.Google Scholar
Seo, B.S., Lee, S.H., Hong, S.J., Kim, C.Y. & Lee, H.Y. (1982) Studies on intestinal trematodes in Korea V. A human case infected by Fibricola seoulensis (Trematoda: Diplostomatidae). Korean Journal of Parasitology 20, 93–99.CrossRefGoogle Scholar
Shoop, W.L. (1989) Experimental human infection with Fibricola cratera (Trematoda: Neodiplostomidae). Korean Journal of Parasitology 27, 249–252.CrossRefGoogle ScholarPubMed
Skrjabin, K.I. (1965) Trematodes of animals and man. Essentials of trematodology Vol. XVIII, 387–396. Jerusalem, Israel Program for Scientific Translations Ltd.Google Scholar
Skrjabin, K.I. (1982) Trematodes of animals and man. Fundamentals of trematodology. Vol. XXIV, pp. 299–302. New Delhi, Amerind Publishing Co. Pvt. Ltd.Google Scholar
Wallace, F.G. (1937) A new diplostomulum from China. Journal of Parasitology 23, 215–217.CrossRefGoogle Scholar
Wallace, F.G. (1939) The life cycle of Pharyngostomum cordatum (Diesing) Ciurea (Trematoda: Alariidae). Transactions of the American Microscopical Society 58, 49–61.CrossRefGoogle Scholar