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Fasciola antigens as vaccines against fascioliasis and schistosomiasis

Published online by Cambridge University Press:  12 April 2024

G.V. Hillyer
G.V. Hillyer*
Affiliation:
Department of Pathology and Laboratory Medicine, University of Puerto Rico School of Medicine, PO Box 365067, San Juan, PR 00936-5067, Puerto Rico
*
*Author for correspondence Fax: (787) 751 9210 E-mail: ghillyer@rcm.upr.edu
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Abstract

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Fascioliasis is an important trematode infection of herbivores worldwide with increasing evidence of prevalence as a disease of humans. Vaccination studies with purified native and recombinant Fasciola antigens suggest that this approach to diminished morbidity and mortality and reduced transmission is a realistic goal. Among the major potential vaccine candidates are fatty acid binding protein (FABP), cysteine (cathepsin) proteases, haemoglobulin, leucine aminopeptidase, and a saposin-like protein. In the case of Fasciola hepatica FABP, cross-reaction and cross-protection against Schistosoma mansoni is an important feature. In addition to protective effects with significant worm burden reductions, some vaccine candidates also have anti-fecundity (smaller flukes), anti-pathology (less liver lesions), and anti-embryonation effects. Optimism is tempered by the fact that fascioliasis in humans is an orphan disease and in need of governmental and foundation support.

Type
Review Article
Information
Journal of Helminthology , Volume 79 , Issue 3 , September 2005 , pp. 241 - 247
Copyright
Copyright © Cambridge University Press 2005

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