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Histopathology of the small intestinal mucosa in Nematodirus spathiger infection in rabbits

Published online by Cambridge University Press:  05 June 2009

H. Hoste ,
S. Mallet  and
G. Fort
H. Hoste
Affiliation:
INRA – Centre de Recherches de Tours, Station de Pathologie Aviaire et de Parasitologie, F37380 Nouzilly, France
S. Mallet
Affiliation:
INRA – Centre de Recherches de Tours, Station de Pathologie Aviaire et de Parasitologie, F37380 Nouzilly, France
G. Fort
Affiliation:
INRA – Centre de Recherches de Tours, Station de Pathologie Aviaire et de Parasitologie, F37380 Nouzilly, France
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Abstract

Rabbits were experimentally infected with two levels (5000 and 17000) infective larvae of Nematodirus spathiger. Histological (villus length, mucosa to serosa ratio, crypt surface) and biochemical (protein content, alkaline phosphatase and leucine aminopeptidase activities) measurements relating to the small intestinal mucosa were examined along the entire length of the organ. In the proximal intestine, the presence of worms was associated with villus abrasion, increased crypt surface and decreased alkaline phosphatase and leucine aminopeptidase activities. Conversely, beyond the main Site of infection in the distal small intestine, some signs of hypertrophied villi and crypts were noted without any changes in enzyme activities. These distal variations were similar to those previously described in experimental Trichostrongylus colubriformis infections of rabbits. These results tend to confirm the use of the rabbit as an experimental model to study Nematodirus infection. They also suggest that the distal adaptive process in the nematode-parasitized small intestine could occur independently of the worm species.

Keywords

NematodaNematodirus spathigerrabbitsmall intestinealkaline phosphataseleucine aminapeptidasehistologyimage analysis
Type
Research Papers
Information
Journal of Helminthology , Volume 67 , Issue 2 , June 1993 , pp. 139 - 144
Copyright
Copyright © Cambridge University Press 1993

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