Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-26T04:26:03.871Z Has data issue: false hasContentIssue false
  • English
  • Français

The in vitro Effect of Normal and Immune Serum upon the Cercariæ of Schistosoma mansoni

Published online by Cambridge University Press:  18 November 2009

O. D. Standen
O. D. Standen
Affiliation:
The Wellcome Laboratories of Tropical Medicine, London.
Get access Rights & Permissions [Opens in a new window]

Extract

The majority of normal sera proved in vitro to be cercaricidal to larvae of S. mansoni. Of 502 normal sera. 21 per cent, were noncercaricidal whereas the remainder exhibited varying degrees of cercaricidal potency.

The cercaricidal factor was thermolabile and disappeared during storage. It bore several points of similarity to complement.

The cercaricidal factor was present to a varying degree in sera from all species investigated. Apparently normal sera from all cattle and different proportions of other species, caused an enveloping precipitate to form around the cercariae. This bore no obvious relationship to the nematode worm burden or presence of F. hepatica.

An enveloping precipitate formed around cercariae of S. mansoni when placed in vitro in immune sera and incubated at 87°C. This occurred in serum immune to S. haematobium as well as to S. mansoni. It is not known-whether age and weight of infection influence the rate and extent of envelope precipitation.

Type
Research Papers
Information
Journal of Helminthology , Volume 26 , Issue 1 , June 1952 , pp. 25 - 42
Copyright
Copyright © Cambridge University Press 1952

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Blacklock, D. B., Gordon, R. M. and Fine, J., 1930.—“Metazoan Immunity: A report on recent investigations.” Ann. trop. Mtd. Parasit., 24, 5. (W.L. 1063.)CrossRefGoogle Scholar
Ch'ien Lu, and Bang, F. B., 1950. “Agglutination of Cercariae of S. mansoni by Immune Sera.” Proc. Soc. exp. Biol. N.Y., 74, 68. (W.L. 16913.)Google Scholar
Culbertson, J. T., 1936.—“The Ccrcaricidal Action of Normal Serums.” J. Parasit., 22, 111. (W.L. 11428.)CrossRefGoogle Scholar
Lawler, H. J., 1940.—“Passive Transfer of Immunity to the Nematotle Strongyloides ratti.” Amer. J. Hyg., 31 (2), 28–31. (W.L., 600a.)Google Scholar
Mauss, E. A., 1940.—“The in vitro Effect of Immune Serum upon Trichinella spiralis larvae.” Amer. J. Hyg., 32, D 80. (W.L. 600a.)Google Scholar
Oliver-Gonzalez, J., 1940.—“The in vitro Action of Immune Serum on the Larvae and Adults of Trichinella spiralis.” J. infect. Dis., 67, 292. (W.L. 11250.)Google Scholar
Otto, G. F., 1940.—“A Serum Antibody in Dogs Actively Immunized against the Hookworm, Ancylostoma caninum.” Amer. J. Hyg., 31, D 23. (W.L. 600a.)Google Scholar
Papirmeister, B. and Bang, F. B., 1948.—“The in vitro Action of Immune Sera on Cercariae of S. mansoni.” Amer. J. Hyg., 48, 74. (W.L. 600a.)Google Scholar
Roth, H., 1945.—“Scrodiagnosis of Trichinosis by Microscopical Testing with Living Trichina Larvae.” Nature, Land., 155, 758. (W.L. 14900.)Google Scholar
Roth, H., 1946.—“Employment of Serological and Skin Tests at Outbreaks of Trichinosis in the Alingsas and Boras Districts (Sweden).” Acta med. scand., 126, 17. (W.L. 114.)Google Scholar
Sables, M.P., 1938.—“The in vitro Action of Immune Rat Serum on the Nematode, Nippostrongylus muris.” J. infect. Dis., 62, 337. (W.L. 11250.).Google Scholar
Standen, O. D., 1950.—“The Concentration of Cercariae of S. mansoni for the Preparation of Cercarial Antigen.” Trans. R. Soc. trop. Med. Hyg., 43, 527. (W.L. 21671).CrossRefGoogle Scholar
Tubangui, M. A. and Masilungan, V. A., 1936.—“Studies on the Cercaricidal Property of the Sera of Vertebrate Animals.” Philipp. J. Sci., 60, 393. (W.L. 16189.)Google Scholar
Vogel, H. and Minning, W., 1949.—“Hullenbildung bei Bilharzia-Cercarien in Serum bilharzia-infizierter Tiere und Menschen.” Zbl. Bakt. Abt. L. Orig., 153. 91. (W.L. 23684.)Google Scholar
Vogel, H. and Minning, W., 1949a.—“Weitere Bcobachtungen ttber die Cercaricn-hüllenreaktion, cine Seroprazipitaticn mit lebenden Bilharzia-Cercarien.” Z. Tropenmed. Parasit., 1, 378.Google Scholar