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In vitro effects of mebendazole on the carbohydrate metabolism of Avitellina lahorea (Cestoda)

Published online by Cambridge University Press:  05 June 2009

M. Ahmad  and
W. A. Nizami
M. Ahmad
Affiliation:
Section of Parasitology, Department of Zoology, Aligarh Muslim University, Aligarh–202 001, India
W. A. Nizami*
Affiliation:
Section of Parasitology, Department of Zoology, Aligarh Muslim University, Aligarh–202 001, India
*
* To whom all correspondence should be addressed.
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Abstract

Mebendazole (3.3 μmol), causes in vitro glycogen depletion and inhibits glucose uptake in Avitellina lahorea. Inhibition of non-specific phosphomonoesterases and adenosine triphosphatase by mebendazole is discussed in the light of the role of phosphatases in uptake mechanisms. Mebendazole has no effect on hexokinase which has broad substrate specificity but influences the activities of some glycolytic enzymes such as phosphorylase, phosphoglucomutase and glucose-6-phosphatase. Thus, it appears that mebendazole also acts to disrupt certain enzymes of carbohydrate metabolism which may ultimately cause death of the parasite.

Keywords

mebendazoleAvitellina lahoreacarbohydrate metabolism
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 3 , September 1987 , pp. 247 - 252
Copyright
Copyright © Cambridge University Press 1987

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