Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-15T01:25:45.607Z Has data issue: false hasContentIssue false
  • English
  • Français

Increased IgG antibody responses to excretory/secretory antigens in neonates born from mothers infected with filarial nematodes

Published online by Cambridge University Press:  28 October 2016

K.G. Achary ,
M.S. Bal ,
N.N. Mandal  and
A.K. Satapathy
K.G. Achary
Affiliation:
Division of Immunology, Regional Medical Research Center (Indian Council of Medical Research), Chandrasekharpur, Bhubaneswar – 751023, Odisha, India
M.S. Bal
Affiliation:
Division of Immunology, Regional Medical Research Center (Indian Council of Medical Research), Chandrasekharpur, Bhubaneswar – 751023, Odisha, India
N.N. Mandal
Affiliation:
Division of Immunology, Regional Medical Research Center (Indian Council of Medical Research), Chandrasekharpur, Bhubaneswar – 751023, Odisha, India
A.K. Satapathy*
Affiliation:
Division of Immunology, Regional Medical Research Center (Indian Council of Medical Research), Chandrasekharpur, Bhubaneswar – 751023, Odisha, India
*
*Fax: 0674-2301351 E-mail: aksatapathy@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

The present investigation aimed to evaluate the extent to which maternal filarial infection influences IgG subclass immune responses in the cord blood of neonates. Prevalence of antigenaemia was detected using an Og4C3 assay. Filaria-specific IgG subclasses against excretory/secretory antigens were measured by ELISA. Transplacental transfer of circulating filarial antigen (CFA) was observed from 34.8% of CFA-positive mothers to their respective cord bloods. Filaria-specific IgG1, IgG2 and IgG4 responses were significantly higher among cord bloods of infected mothers compared to cord bloods of uninfected mothers. In contrast, the IgG3 response was significantly higher among cord bloods of uninfected mothers. The study shows that transplacental transfer of filarial antigens and filaria-specific IgG4 occurs more in mothers having high worm burdens, and transfer of filaria-specific IgG3 occurs more in the cord blood of uninfected mothers. The findings of the study provide evidence for the development of prenatal sensitization to filarial antigens in utero, and high filaria-specific IgG4 in cord blood may serve as a marker for in-utero sensitization.

Type
Short Communications
Information
Journal of Helminthology , Volume 91 , Issue 6 , November 2017 , pp. 752 - 756
Copyright
Copyright © Cambridge University Press 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

†

These authors contributed equally.

References

Achary, K.G., Mandal, N.N., Mishra, S., Mishra, R., Sarangi, S.S., Satapathy, A.K., Kar, S.K. & Bal, M.S. (2014) In-utero sensitization modulates IgG isotype, IFN-γ and IL-10 responses of neonates in bancroftian filariasis. Parasite Immunology 36, 485–493.Google Scholar
Adjobimey, T. & Hoerauf, A. (2010) Induction of immunoglobulin G4 in human filariasis: an indicator of immune-regulation. Annals of Tropical Medicine and Parasitology 104, 455–464.CrossRefGoogle Scholar
Bal, M.S. & Das, M.K. (1999) Antibody response to a filarial antigen fraction in individuals exposed to Wuchereria bancrofti infection in India. Acta Tropica 72, 259–274.CrossRefGoogle ScholarPubMed
Bal, M.S., Mandal, N.N., Das, M.K., Kar, S.K., Sarangi, S.S. & Beuria, M.K. (2010) Transplacental transfer of filarial antigens from Wuchereria bancrofti-infected mothers to their offspring. Parasitology 137, 669–673.CrossRefGoogle ScholarPubMed
Bal, M.S., Sahu, P.K., Mandal, N.N., Satapathy, A.K., Ranjit, M. & Kar, S,K. (2015) Maternal infection is a risk factor for early childhood infection in filariasis. PLOS Neglected Tropical Disease 9. doi:10.1371/journal.pntd.0003955.Google Scholar
Hashira, S., Okitsu-Negishi, S. & Yoshino, K. (2000) Placental transfer of IgG subclasses in a Japanese population. Pediatrics International 42, 337–342.CrossRefGoogle Scholar
Hightower, A.W., Lammie, P.J. & Eberhard, M.L. (1993) Maternal filarial infection – a persistent risk factor for microfilaremia in offspring? Parasitology Today 9, 418–421.CrossRefGoogle ScholarPubMed
Hitch, W.L., Eberhard, M.L. & Lammie, P.J. (1997) Investigation of the influence of maternal infection with Wuchereria bancrofti on the humoral and cellular responses of neonates to filarial antigens. Annals of Tropical Medicine and Parasitology 91, 461–469.CrossRefGoogle ScholarPubMed
Lammie, P.J. (2002) In utero exposure to filarial antigen and its influence on infection outcomes. pp. 97–107 in Klei, T.R. & Rajan, T.V. (Eds) The filaria. Dordrecht, The Netherlands, Kluwer Academic.Google Scholar
Lammie, P.J., Reiss, M.D., Dimock, K.A., Streit, T.G., Roberts, J.M. & Eberhard, M.L. (1998) Longitudinal analysis of the development of filarial infection and antifilarial immunity in a cohort of Haitian children. American Journal of Tropical Medicine and Hygiene 59, 217–221.CrossRefGoogle Scholar
Malhotra, I., Mungai, P.L, Wamachi, A.N., Tisch, D., Kioko, J.M., Ouma, J.H., Muchiri, E., Kazura, J.W. & King, C.L. (2006) Prenatal T cell immunity to Wuchereria bancrofti and its effect on filarial immunity and infection susceptibility during childhood Journal of Infectious Diseases 193, 1005–1013.Google Scholar
Scpulveda, W.B.C., Youlton, R., Gutierrez, J. & Carstens, E. (1999) Accuracy of the hemoglobin denaturation test for detecting maternal blood contamination of foetal blood samples for parental karyotyping. Prenatal Diagnosis 19, 927–929.Google Scholar
Terhell, A.J., Wahyuni, S., Pryce, A., Koot, J.W., Abadi, K. & Yazdanbakhsh, M. (2002) Anti-filarial and total IgG4 and IgE antibody levels are correlated in mothers and their offspring. Transactions of the Royal Society of Tropical Medicine and Hygiene 96, 334–339.Google Scholar
WHO. (2006) Global programme to eliminate lymphatic filariasis. Weekly Epidemiological Record 81, 221–232.Google Scholar