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Kinetic disposition of albendazole in goats subclinically infected with gastrointestinal nematodes vis-à-vis naive animals following oral and intraruminal administration

Published online by Cambridge University Press:  01 March 2008

A.K. Dubey ,
P.K. Sanyal ,
K.M. Koley ,
P.L. Chaudhary ,
K. Mukherjee ,
S.C. Mandal  and
S. Pal
A.K. Dubey
Affiliation:
Department of ParasitologyCollege of Veterinary Science and Animal Husbandry, Indira Gandhi Krishi Viswavidyalaya, Anjora, Durg 491 001, Chhattisgarh, India
P.K. Sanyal*
Affiliation:
Department of ParasitologyCollege of Veterinary Science and Animal Husbandry, Indira Gandhi Krishi Viswavidyalaya, Anjora, Durg 491 001, Chhattisgarh, India
K.M. Koley
Affiliation:
Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Indira Gandhi Krishi Viswavidyalaya, Anjora, Durg 491 001, Chhattisgarh, India
P.L. Chaudhary
Affiliation:
Department of Dairy Chemistry, College of Dairy Technology, Indira Gandhi Krishi Viswaridyalaya, Raipur, Chhattisgarh, India
K. Mukherjee
Affiliation:
Department of Animal Genetics and Breeding, College of Veterinary Science and Animal Husbandry, Indira Gandhi Krishi Viswavidyalaya, Anjora, Durg 491 001, Chhattisgarh, India
S.C. Mandal
Affiliation:
Department of ParasitologyCollege of Veterinary Science and Animal Husbandry, Indira Gandhi Krishi Viswavidyalaya, Anjora, Durg 491 001, Chhattisgarh, India
S. Pal
Affiliation:
Department of ParasitologyCollege of Veterinary Science and Animal Husbandry, Indira Gandhi Krishi Viswavidyalaya, Anjora, Durg 491 001, Chhattisgarh, India
*
*Fax: 91 788 2252139 E-mail: sanyalpk@rediffmail.com
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Abstract

The influence of subclinical nematodosis on the kinetic disposition of albendazole was evaluated in goats following oral and intraruminal administration. The disposition curves of its metabolites indicated increased uptake of the drug in parasitized goats following intraruminal compared to oral dosing (P < 0.05). The midpoint for the pharmacologically active metabolite, albendazole sulphoxide, in the circulatory compartment was around 0.6 μg ml− 1 both in parasitized and naïve goats. The period of exposure to this concentration was around 14 h (oral route), 18 h (intraruminal route) and 16 h (oral route), 17 h (intraruminal route) in parasitized and naïve goats, respectively. As the duration of exposure of parasites to the toxic concentration of the anthelmintically active metabolite was prolonged, it could be assumed that intraruminal delivery of the drug would improve the efficacy of albendazole in parasitized goats.

Type
Research Papers
Information
Journal of Helminthology , Volume 82 , Issue 1 , March 2008 , pp. 17 - 23
Copyright
Copyright © Cambridge University Press 2007

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