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A morphological study of the effects of liposomized albendazole on the muscle phase of Trichinella spiralis in mice

Published online by Cambridge University Press:  05 June 2009

G. Hrčkova ,
S. Velebny  and
J. Horák
G. Hrčkova
Affiliation:
Helminthological Institute, Slovak Academy of Sciences, Dukelsky˘ch hrdinov 3,0401 Košice, Slovakia
S. Velebny
Affiliation:
Helminthological Institute, Slovak Academy of Sciences, Dukelsky˘ch hrdinov 3,0401 Košice, Slovakia
J. Horák
Affiliation:
Department of Cellular and Molecular Biology. P. J. Šafarik University, Mojzesova 11,041 67 Košice, Slovakia
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Abstract

The pathomorphological effects of daily and weekly doses of liposomized albendazole on Trichinella spiralis larvae have been examined and compared during the course of muscle infections in mice. Treatment with three and six daily doses of the drug given by intraperitoneal injection to mice resulted in marked pathological alterations to encapsulated larvae, mainly in the walls of the capsules. There was a 5% efficacy against T. spiralis in mice given three daily doses of albendazole, and 38% efficacy in mice given six daily doses of the drug. The same doses of drug, when administered weekly, did not reduce the numbers of parasite larvae, and the application of drug at 6-weekly intervals resulted in a 5% reduction in numbers.

Keywords

Trichinella spiralislarvaeNematodaalbendazoleliposomespathomorphologymouse
Type
Research Papers
Information
Journal of Helminthology , Volume 67 , Issue 1 , March 1993 , pp. 24 - 30
Copyright
Copyright © Cambridge University Press 1993

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References

REFERENCES

Bangham, A. D., Hill, M. W. & Miller, N. G. A. (1974) Preparation and use of liposomes as models of biological membranes. In: Methods in Membrane Biology (editor, Korn, E. D.) pp. 1–68. Plenum Press: New York.Google Scholar
Bligh, E. G. & Dyer, W. J. (1959) A rapid method of total lipid extraction and purification. Canadian Journal of Biochemistry and Physiology, 37, 153–155.Google Scholar
Bogan, J. A. & Marriner, S. E. (1983) Pharmacodynamic and toxicological aspects of albendazole in man and animals. In: Albendazole in Helminthiasis (editor, Etang, H.-J. C. L') pp. 13–21. International Congress and Symposium Series 61: Cairo.Google Scholar
Bruce, R. G. (1970) The structure and composition of the capsule of Trichinella spiralis in host muscle. Parasitology, 60, 223–227.CrossRefGoogle ScholarPubMed
Delatour, P. & Burgat-Sacaze, V. (1981) Towards an alternative procedure for the toxicological assessment of residues? Application to benzimidazoles. Recueil de Medecine Veterinaire de L' Ecole d' Alfort, 157, 213–218.Google Scholar
DeNollin, S., Borgers, M., Vanparus, O. & Van Den Bossche, H. (1974) Effects of mebendazole on the encysted phase of Trichinella spiralis in the rat: an electron-microscope study. Parasitology, 69, 55–62.Google Scholar
Despommier, D. D. (1990) Trichinella spiralis: the worm that would be virus. Parasitology Today, 6, 193–196.CrossRefGoogle ScholarPubMed
Gregoriadis, G. (1976) The carrier potential of liposomes in biology and medicine (first of two parts). The New England Journal of Medicine, 295, 704–710.CrossRefGoogle ScholarPubMed
Gould, S. E. (1970) Trichinosis in Man and Animals (editor, Gould, S. E.). Charles C. Thomas, Springfield, Illinois.Google Scholar
Gutierrez-Palomino, P., Hernandez-Rodriguez, S., Martinez-Gomez, F. & Acostagarcia, I. (1988) Muscular phase of Trichinella spiralis treated with oxfendazole. Proceedings of the Seventh International Conference on Trichinellosis (Spain). 490–493.Google Scholar
Hirano, K. & Hunt, A. (1985) Lymphatic transport of liposome-encapsulated agents: effects of liposome size following intraperitoneal administration. Journal of Pharmaceutical Sciences, 74, 915–921.CrossRefGoogle ScholarPubMed
Horton, R. J. (1990) Benzimidazoles in a wormy world. Parasitology Today, 6, 106–107.CrossRefGoogle Scholar
Kozar, Z., Zarzycki, J. & Kozar, M. (1966) Morphological observations of Trichinella infected muscles in mice treated with thiabendazole and Neguvon. Wiadomosci Parasitologiczne, 12, 589–604.Google ScholarPubMed
Lacey, E. (1990) Mode of action of benzimidazoles. Parasitology Today, 6, 112–115.CrossRefGoogle ScholarPubMed
McCracken, R. O. (1978) Efficacy of mebendazole and albendazole against Trichinella spiralis in mice. Journal of Parasitology, 64, 214–219.Google Scholar
Pereverzeva, E. V., Ozeretkovskaya, N. N. & Veretennikova, N. L. (1976) Efficacy of carbamate benzimidazole derivatives and morphological changes in parasite and host muscle tissue in experimental trichinellosis. Proceedings of the Fourth International Conference on Trichinellosis. (55–62).Google Scholar
Pereverzeva, E. V., Veretennikova, N. L. & Ozeretkovskaya, N. N. (1980) The effect of benzimidazoles on inflammatory cell reactions in mice in experimental trichinellosis. Proceedings of the Fifth International Conference on Trichinellosis. (311–315).Google Scholar
Spaldonova, R. & Corba, J. (1979) Relationship between the antitrichinellous effect of seven derivatives of benzimidazole carbamates and their clinical structures. Folia Parasitologia, 26, 145–149.Google Scholar
Stewart, G. L. & Charniga, L. M. (1980) Distribution of Trichinella spiralis in muscle of the mouse. Journal of Parasitology, 66, 688–689.Google Scholar
Townsend, L. B. & Wise, D. S. (1990) The synthesis and chemistry of certain anthelmintic benzimidazoles. Parasitology Today, 6, 107–112.CrossRefGoogle ScholarPubMed
Velebny, S., Spaldonova, R. & Corba, J. (1979) Electronical counting of Trichinella spiralis larvae. Helminthologia, 16, 199–206.Google Scholar