Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-28T17:33:04.944Z Has data issue: false hasContentIssue false

Rapid recovery of Echinococcus granulosus following ‘successful’ albendazole therapy in a gerbil model

Published online by Cambridge University Press:  05 June 2009

D. H. Taylor
Affiliation:
Department of Surgery, University Hospital, Nottingham NG7 2UH, UK
K. S. Richards
Affiliation:
Department of Biological Sciences, University of Keele, Keele, Staffordshire ST5 5BG, UK
D. L. Morris*
Affiliation:
Department of Surgery, University Hospital, Nottingham NG7 2UH, UK
*
Author for correspondence.

Abstract

Peritoneal Echinococcus granulosus in gerbils was treated with albendazole. Both early and late infections were studied; response to albendazole therapy and the ability of the parasite to recover after treatment was found to depend on dose and length of therapy. Even after treatment at 50 mg/kg for 2 months late infections retained the ability to recover over 3 months.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1989

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Chinnery, J. & Morris, D. L. (1986) Effect of albendazole sulphoxide on viability of hydatid protoscoleces. Transactions of the Royal Society of Tropical Medicine and Hygiene, 80, 815817.CrossRefGoogle ScholarPubMed
Marriner, S., Morris, D. L., Dickson, B. & Bogan, J. (1986) Pharmacokinetics of albendazole in man. European Journal of Clinical Pharmacology, 30, 705708.CrossRefGoogle ScholarPubMed
Morris, D. L. (1987) Long term results of albendazole therapy of hydatid disease: clinical and experimental results. Gut, 20, 1385.Google Scholar
Morris, D. L., Clarkson, M. J., Stallbaum, M. F., Pritchard, S., Jones, P. S. & Chinnery, J. B. (1985a) Albendazole treatment of pulmonary hydatid cysts in naturally infected sheep; a study with relevance to man. Thorax, 40, 453458.CrossRefGoogle ScholarPubMed
Morris, D. L., Dykes, P. W., Marriner, S., Bogan, J., Burrows, F., Skeenesmith, H. & Clarkson, M. J. (1985b) Albendazole—objective evidence of response in human hydatid disease. Journal of the American Medical Association, 253, 20532057.Google ScholarPubMed
Morris, D. L., Skeene Smith, H. & Burrows, F. (1984) Abdominal hydatid disease—computed tomographic and ultrasound changes during albendazole therapy. Clinical Radiology, 35, 297300.CrossRefGoogle Scholar
Taylor, D. H., Morris, D. L. & Richards, K. S. (1989) Albendazole is effective against E. granulosus in gerbils: comparison of serum concentrations achieved by gavage and feed administration. Annals of Tropical Medicine and Parasitology, (in press).CrossRefGoogle Scholar