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Schistosoma japonicum and S. mansoni: comparison of larval migration patterns in mice

Published online by Cambridge University Press:  05 June 2009

M. Gui ,
J.R. Kusel ,
Y.E. Shi  and
A. Ruppel
M. Gui
Affiliation:
Institute of Tropical Hygiene, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany Depertment of Parasitology, Tongji Medical University, 430030 Wuhan, People's Republic of China
J.R. Kusel
Affiliation:
Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, UK
Y.E. Shi
Affiliation:
Depertment of Parasitology, Tongji Medical University, 430030 Wuhan, People's Republic of China
A. Ruppel*
Affiliation:
Institute of Tropical Hygiene, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
*
*Author for the correspondence.
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Abstract

Mice were infected percutaneously with cercariae of Schistosoma japonicum or S. mansoni and parasites recovered by tissue-mincing from the skin or lungs or by perfusion of the mesenteric veins. S. japonicum had a narrow peak of recovery (up to 30%) from the lungs 3 days after infection, whereas lung recovery of S. mansoni peaked only on day 6 and levelled off during the following week. Infection with S. japonicum induced lung petechiae, but only after most of the parasites had left the lungs. The axillary lymph nodes draining the infection site increased in weight after infection and this effect was much greater and longer with S. mansoni than with S. japonicum. S. japonicum was perfusable from the mesenteric veins earlier (from day 3 onwards) and in higher number (40–60% from days 6 to 10) than S. mansoni (20% on day 20). The percentage of cercariae developing to adult worms was 57% for S. japonicum and 33% for S. mansoni. The data demonstrate that S. japonicum might escape from local tissue reactions in the skin and lungs and, due to its rapid migration, might induce only poor lymphocyte proliferation. As a possible consequence, S. japonicum may establish more efficiently in mice than S. mansoni.

Type
Research Papers
Information
Journal of Helminthology , Volume 69 , Issue 1 , March 1995 , pp. 19 - 25
Copyright
Copyright © Cambridge University Press 1995

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