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Studies of potential filaricides: Part 14—Activity of l-iso-butoxycarbonyl-4-methyIpiperazine against experimental filariasis*

Published online by Cambridge University Press:  05 June 2009

R. Rastogi ,
S. Sharma ,
N. Anand ,
A. Dutta ,
N. Fatma ,
R. K. Chatterjee  and
A. B. Sen
R. Rastogi
Affiliation:
Medical Chemistry Division
S. Sharma
Affiliation:
Medical Chemistry Division
N. Anand
Affiliation:
Medical Chemistry Division
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Abstract

The synthesis and filaricidal activity of l-iso-butoxycarbonyl-4-mcthylpipcrazinc against Litomosoides carinii in Sigmodon hispidus and Dipctaloncma viteae in Mastomys natalcnsis is reported. At an intrapcritoncal or oral dose of 3 mg/kg given for 6 days, the compound removed 91% of the circulating microfilariac but had no effect on adult L carinii. However, it killed all microfilariae and adults of D. viteae at a subcutaneous dose of 50 mg/kg given for 6 days. The compound also possessed ehemoprophylaetic activity against the larvae of L. carinii and D. viteae at a dose of 30 and 50 mg/kg respectively.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 3 , September 1984 , pp. 251 - 254
Copyright
Copyright © Cambridge University Press 1984

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References

REFERENCES

Anand, N., Sen, A.B., Chatterjee, R.K. & Sharma, S. (1983) Chemotherapy of filariasis—Many challenges, some achievements. In: Chemotherapy and Immunology in the control of Filariasis, Malaria and Leishmaniasis. (Anand, N., Sen, A. B., Editors) Tata McGraw Hill, New Delhi, pp. 211–230.Google Scholar
Hawking, F. & Sewell, P. (1948) The maintenance of a filarial infection (Litomosoides carinii) for chemotherapeutic investigations. British Journal of Pharmacology and Chemotherapy, 3, 285–296.CrossRefGoogle ScholarPubMed
Hewitt, R.I., White, E., Wallace, W.S., Stewart, H.W., Kushner, S. & Subbarow, Y. (1947) Experimental chemotherapy of filariasis. II. Effect of pipcrazinc derivatives against naturally acquired filarial infections in cotton rats and dogs. Journal of Laboratory and Clinical Medicine, 32, 1304–1313.Google Scholar
Lämmler, G., Herzog, H. & Schütze, H.R. (1971a) Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 2. The activity of drugs against microfilaria. Bulletin of the World Health Organization, 44, 757–763.Google Scholar
Lämmler, G., Herzog, H. & Schütze, H.R. (1971b) Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 3. The activity of drugs against adult parasites. Bulletin of the World Health Organization, 44, 765–770.Google ScholarPubMed
Misra, S., Chatterjee, R.K. & Sen, A.B. (1981) Antifilarial action of furazolidone. Indian Journal Medical Research, 73, 725–728.Google ScholarPubMed
Rastogi, R., Sharma, S., Anand, N., Chowdhury, T.K.R., Chowdhury, T.K., Tyagi, K., Murthy, P.K., Chatterjee, R.K. & Sen, A.B. (1983) A process for the synthesis of 1,4-disubstitutcd piperazines. Indian Patent Application 320/Del/83, 05 16, 1983.Google Scholar
Singh, H., Sharma, S., Iyer, R.N. & Anand, N. (1976a) Studies in potential filaricides: Part VIII—Synthesis of 1-cthyl-3-(2-dialkylaminoethyl) and 1,3-dicthyl-4-dialkylamino mcthylhcxahydropyrimidin- 2-oncs. Indian Journal of Chemistry, 14B, 528–531.Google Scholar
Singh, H., Sharma, S., Iyer, R.N. & Anand, N. (1976b) Studies in potential filaricides: Part IX—Synthesis of 1-cthyl-6-oxo-1,4-diazabicyclo[4,3,1]nonan-5-onc, 1,6-dialky1-1,4,6-triazabicyclo[4,3,1]nonan-5-onc and related thio analogs. Indian Journal of Chemistry, 14B, 532–535.Google Scholar
Sharma, S., Iyer, R.N., Anand, N., Chatterjee, R.K., Chandra, S., Dutta, A. & Sen, A.B. (1975a) A process for the synthesis of antifilarial-1-substituted-4-carbamoylpiperazines. Indian Patent No. 141941; Chemical Abstract (1980) 92, 164002c.Google Scholar
Sharma, S., Iyer, R.N. & Anand, N. (1975b) Studies in potential filaricides: Part VII—Synthesis of 4,8-dialkyl-1,4,8-triazabicyclo[4,4,0]dccan-2-one, 3,7-diallcyl-1,3,7-triazabicyclo[4,3,0]nonan-2-one and related oxygen analogs. Indian Journal of Chemistry, 13B, 468–472.Google Scholar
Sharma, S., Bindra, R., Iyer, R.N. & Anand, N. (1975c) Studies in potential filaricides. Part VI—Synthesis of 3,8-disubstituted-1,3,8-triazabicyclo[4,4,0]decon-2-ones and thioncs. Journal of Medicinal Chemistry, 18, 913–917.CrossRefGoogle Scholar
Wadia, P.S., Asthana, T.C., Anand, N. & Dhar, M.L. (1958a) Studies in Potential Filaricides: Part-I—Synthesis of N,N-disubstitutcd polymethylene Diamines as Hetrazan Analogs. Journal of Scientific and Industrial Research, 17B, 11–24.Google Scholar
Wadia, P.S., Anand, N. & Dhar, M.L. (1958b) Studies in potential filaricides: Part II—Synthesis of substituted imidazolidines and 2-imidazolidinethiones. Journal of Scientific and Industrial Research, 17B, 24–30.Google Scholar