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Association of synchronous medullary and papillary thyroid carcinomas with primary hyperparathyroidism: first case report and literature review

Published online by Cambridge University Press:  30 May 2014

L Cheung ,
D Howlett ,
H El Teraifi  and
P Kirkland
L Cheung*
Affiliation:
Department of ENT, Conquest Hospital, East Sussex Healthcare NHS Trust, St. Leonards-on-Sea, UK
D Howlett
Affiliation:
Department of Radiology, Eastbourne District General Hospital, UK
H El Teraifi
Affiliation:
Department of Pathology, Eastbourne District General Hospital, UK
P Kirkland
Affiliation:
Department of ENT, Conquest Hospital, East Sussex Healthcare NHS Trust, St. Leonards-on-Sea, UK
*
Address for correspondence: Miss L Cheung, Conquest Hospital, East Sussex Healthcare NHS Trust, The Ridge, St. Leonards-on-Sea, TN37 7RDUK E-mail: linnea.cheung@nhs.net
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Abstract

Objective:

We report a case of a patient with symptomatic primary hyperparathyroidism who was found, through a thorough radiological investigation, to also have papillary and medullary thyroid carcinomas.

Case report:

A 59-year-old female was diagnosed with primary hyperparathyroidism. A further radiological investigation found suspicious areas within both thyroid lobes that were later diagnosed as foci of papillary and medullary thyroid carcinomas. Appropriate treatment was commenced. Reports of similar occurrences of synchronous thyroid and parathyroid pathologies are discussed.

Conclusion:

To our knowledge, this is the first reported case of two synchronous thyroid cancers occurring in the context of primary hyperparathyroidism. We strongly recommend a thorough radiological investigation of all patients with primary hyperparathyroidism to prevent missing concurrent thyroid cancers.

Keywords

Thyroid NeoplasmsHyperparathyroidism, PrimaryThyroid Cancer, MedullaryRET Protein, HumanCarcinoma, Papillary
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 6 , June 2014 , pp. 565 - 568
Copyright
Copyright © JLO (1984) Limited 2014 

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