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Brown tumour of hyperparathyroidism in the mandible associated with atypical parathyroid adenoma

Published online by Cambridge University Press:  08 March 2006

Oran Goshen ,
Sarit Aviel-Ronen ,
Shay Dori  and
Yoav P. Talmi
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Abstract

The brown tumour of hyperparathyroidism is a localized bone tumour and an uncommon manifestation of hyperparathyroidism. A 27-year-old woman presented with a mandibular 8 × 10 cm solid mass diagnosed as central giant cell granuloma. Chemical blood analysis revealed increased serum calcium levels of 12.46 mg/dL and the parathyroid hormone level was 124 pg/dL. The patient underwent surgery with removal of a parathyroid mass. Histologically, this parathyroid tissue was seen to be limited by a fibrous capsule with morphological features consistent with atypical parathyroid adenoma. The mandibular tumour has receded and the patient declined further procedures. This is the first case reported of brown tumour as the primary manifestation of an atypical parathyroid adenoma, a lesion that shares some features with parathyroid carcinoma without the unequivocal properties of malignancy.

Keywords

Parathyroid diseasesHyperparathyroidismParathyroid neoplasmsGiant celltumoursAdenoma
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 114 , Issue 4 , April 2000 , pp. 302 - 304
Copyright
Royal Society of Medicine Press Limited 2000

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