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A comparative histopathological study of vocal fold polyps in smokers versus non-smokers

Published online by Cambridge University Press:  19 March 2015

K G Effat  and
M Milad
K G Effat*
Affiliation:
Department of Otolaryngology, El-Sahel Teaching Hospital, Cairo, Egypt
M Milad
Affiliation:
Department of Pathology, Cairo University Hospital, Egypt
*
Address for correspondence:Dr K G Effat, 6 Falaky Square, Cairo, Egypt E-mail: kamaleffat@hotmail.com
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Abstract

Background:

A large proportion of patients with vocal fold polyps are cigarette smokers. However, prior to this report no comparative study of polyp histopathology in smokers versus non-smokers had been performed.

Methods:

A prospective histopathological study of vocal fold polyps excised from 29 patients was undertaken. This comprised a comparative analysis of polyp histopathology in smokers versus non-smokers and a review of the pertinent literature.

Results:

Vocal fold polyps were larger in smokers than in non-smokers. Histopathological features significantly associated with the polyps of smokers versus those of non-smokers were increased keratinisation, dysplasia, a basement membrane thinning and hyaline degeneration.

Conclusion:

Cigarette smoke has an injurious effect on vocal fold polyp epithelium and leads to increased hyaline degeneration in polyps.

Keywords

Vocal foldPolypsSmokingHistopathology
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 5 , May 2015 , pp. 484 - 488
Copyright
Copyright © JLO (1984) Limited 2015 

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