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Does the human immunodeficiency virus influence the vestibulocollic reflex pathways? A comparative study

Published online by Cambridge University Press:  28 August 2014

B M Heinze ,
B M Vinck  and
D W Swanepoel
B M Heinze*
Affiliation:
Department of Speech-Language Pathology and Audiology, University of Pretoria, South Africa
B M Vinck
Affiliation:
Department of Speech-Language Pathology and Audiology, University of Pretoria, South Africa
D W Swanepoel
Affiliation:
Department of Speech-Language Pathology and Audiology, University of Pretoria, South Africa Ear Sciences Centre, School of Surgery, University of Western Australia, Nedlands, Australia Ear Science Institute Australia, Subiaco, Australia
*
Address for correspondence:Dr Barbara M Heinze, Department of Speech-Language Pathology and Audiology, Private Bag X20, Hatfield, Pretoria 0028, South Africa Fax: +27 12 4203517 E-mail: barbara.heinze@up.ac.za
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Abstract

Background:

This study compared vestibulocollic reflex and vestibulo-ocular reflex functioning in subjects with and without human immunodeficiency virus. It also described test results throughout progression of the disease and compared the results of human immunodeficiency virus positive subjects who were receiving antiretroviral therapies with those not receiving this treatment.

Methods:

Subjects comprised 53 adults with human immunodeficiency virus (mean age 38.5 ± 4.4 years) and 38 without human immunodeficiency virus (mean age 36.9 ± 8.2 years). Clinical examinations included cervical vestibular-evoked myogenic potential and bithermal caloric testing.

Results:

Abnormal cervical vestibular-evoked myogenic potential and caloric results were significantly higher in the human immunodeficiency virus positive group (p = 0.001), with an odds ratio of 10.2. Vestibulocollic reflex and vestibulo-ocular reflex involvement increased with progression of the disease. There were more abnormal test results in subjects receiving antiretroviral therapies (66.7 per cent) than in those not receiving antiretroviral therapies (63.6 per cent), but this difference was insignificant.

Conclusion:

Human immunodeficiency virus seems to influence vestibulocollic reflex pathways. Combining cervical vestibular-evoked myogenic potential and caloric testing may be useful to detect early neurological involvement in human immunodeficiency virus positive subjects.

Keywords

Human Immunodeficiency VirusVestibulocollic ReflexVestibulo-Ocular ReflexVestibular Evoked Myogenic PotentialsCaloric Testing
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 9 , September 2014 , pp. 772 - 779
Copyright
Copyright © JLO (1984) Limited 2014 

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