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Does the intravenous administration of frusemide reduce endolymphatic hydrops?

Published online by Cambridge University Press:  14 January 2016

F Fiorino ,
B Mattellini ,
M Vento ,
L Mazzocchin ,
L Bianconi  and
F B Pizzini
F Fiorino*
Affiliation:
Department of Otolaryngology, Ospedale Mater Salutis – Azienda Unita Locale Socio Sanitaria 21, Legnago, Italy
B Mattellini
Affiliation:
Department of Otolaryngology, Ospedale di Fidenza, Azienda Unità Sanitaria Parma, Italy
M Vento
Affiliation:
Department of Otolaryngology, Ospedale di Fidenza, Azienda Unità Sanitaria Parma, Italy
L Mazzocchin
Affiliation:
Department of Otolaryngology, Ospedale Sacro Cuore, Negrar, Italy
L Bianconi
Affiliation:
Department of Otolaryngology, Ospedale Civile Maggiore – Azienda Ospedaliera Universitaria Integrata Verona, Italy
F B Pizzini
Affiliation:
Department of Neuroradiology, Ospedale Civile Maggiore – Azienda Ospedaliera Universitaria Integrata Verona, Italy
*
Address for correspondence: Dr Francesco Fiorino, Unità Operativa Complessa di Otorinolaringoiatria, Ospedale Mater Salutis, Via Gianella 1, 37045 Legnago (VR), Italy Fax: +39 0442 622357 E-mail: franco.fiorino@virgilio.it
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Abstract

Objective:

To verify the hypothesis that intravenous frusemide reduces endolymphatic hydrops, as evaluated by three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging following intratympanic gadolinium administration.

Methods:

The study comprised 12 patients (7 females and 5 males, aged 19–74 years) with Ménière's disease. Disease duration ranged from 0.5 to 8 years, with a frequency of 0.5 to 6 vertigo spells per month, as calculated in the last 6 months. Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging was performed 24 hours after intratympanic injection of gadobutrol diluted eight-fold. Frusemide 20 mg was given intravenously immediately after imaging. Magnetic resonance imaging was repeated after 1 hour, using the same parameters and sequence.

Results:

All patients showed enhancement defects, indicating endolymphatic hydrops of variable degrees. No modifications occurred at the second magnetic resonance imaging performed 1 hour after frusemide administration.

Conclusion:

There was no evidence of endolymphatic hydrops modification 1 hour after intravenously administered frusemide. Therefore, loop diuretics in Ménière's disease, which are today used on an empirical basis, must be reconsidered. Implications of these outcomes are discussed and related to the role of endolymphatic hydrops in the development of Ménière's disease.

Keywords

Endolymphatic HydropsMagnetic Resonance ImagingGadoliniumDiuretics
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 3 , March 2016 , pp. 242 - 247
Copyright
Copyright © JLO (1984) Limited 2016 

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References

1Fraysse, BG, Alonso, A, House, WF.Ménière's disease and endolymphatic hydrops: clinical-histopathological correlations. Ann Otol Rhinol Laryngol Suppl 1980;89:2–22CrossRefGoogle ScholarPubMed
2Schuknecht, HF, Gulya, AJ.Endolymphatic hydrops: an overview and classification. Ann Otol Rhinol Laryngol Suppl 1983;106:1–20Google ScholarPubMed
3Okuno, T, Sando, I.Localization, frequency, and severity of endolymphatic hydrops and the pathology of the labyrinthine membrane in Ménière's disease. Ann Otol Rhinol Laryngol 1987;96:438–45CrossRefGoogle ScholarPubMed
4Morita, N, Kariya, S, Farajzadeh Deroee, A, Cureoglu, S, Nomiya, S, Nomiya, R et al. Membranous labyrinth volumes in normal ears and Meniere disease: a three dimensional reconstruction study. Laryngoscope 2009;119:2216–20CrossRefGoogle ScholarPubMed
5Nakashima, T, Naganawa, S, Sugiura, M, Teranishi, M, Sone, M, Hayashi, H et al. Visualization of endolymphatic hydrops in patients with Ménière's disease. Laryngoscope 2007;117:415–20CrossRefGoogle ScholarPubMed
6Nakashima, T, Naganawa, S, Teranishi, M, Tagaya, M, Nakata, S, Sone, M et al. Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease. Acta Otolaryngol 2010;130:338–43CrossRefGoogle ScholarPubMed
7Fiorino, F, Pizzini, FB, Beltramello, A, Barbieri, F.Progression of endolymphatic hydrops in Ménière's disease as evaluated by magnetic resonance imaging. Otol Neurotol 2011;32:1152–7CrossRefGoogle ScholarPubMed
8Fiorino, F, Pizzini, FB, Beltramello, A, Barbieri, F.MRI performed after intratympanic gadolinium administration in patients with Ménière's disease: correlation with symptoms and signs. Eur Arch Otorhinolaryngol 2011;268:181–7CrossRefGoogle ScholarPubMed
9Sone, M, Naganawa, S, Teranishi, M, Nakata, S, Katayama, N, Nakashima, T.Changes in endolymphatic hydrops in a patient with Meniere's disease observed using magnetic resonance imaging. Auris Nasus Larynx 2010;37:220–2CrossRefGoogle Scholar
10Miyagawa, M, Fukuoka, H, Tsukada, K, Oguchi, T, Takumi, Y, Sugiura, M et al. Endolymphatic hydrops and therapeutic effects are visualized in ‘atypical’ Ménière's disease. Acta Otolaryngol 2009;129:1326–9CrossRefGoogle ScholarPubMed
11Kimura, H, Aso, S, Watanabe, Y.Prediction of progression from atypical to definite Ménière's disease using electrocochleography and glycerol and furosemide tests. Acta Otolaryngol 2003;123:388–95CrossRefGoogle ScholarPubMed
12Futaki, T, Kitahara, M, Morimoto, M.The furosemide test for Ménière's disease. Acta Otolaryngol 1975;79:419–24CrossRefGoogle ScholarPubMed
13Ito, M, Watanabe, Y, Shojaku, H, Kobayashi, H, Aso, S, Mizukoshi, K.Furosemide VOR test for the detection of endolymphatic hydrops. Acta Otolaryngol Suppl 1993;504:55–7CrossRefGoogle ScholarPubMed
14Tsunoda, R, Fukaya, T, Komatsuzaki, A.The furosemide test and vestibular status in Ménière's disease. Acta Otolaryngol 1998;118:157–60Google ScholarPubMed
15Seo, T, Node, M, Yukimasa, A, Sakagami, M.Furosemide loading vestibular evoked myogenic potential for unilateral Ménière's disease. Otol Neurotol 2003;24:283–8CrossRefGoogle ScholarPubMed
16American Academy of Otolaryngology-Head and Neck Foundation. Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Ménière's disease. Otolaryngol Head Neck Surg 1995;113:181–5CrossRefGoogle Scholar
17Fiorino, F, Pizzini, FB, Beltramello, A, Mattellini, B, Barbieri, F.Reliability of magnetic resonance imaging performed after intratympanic administration of gadolinium in the identification of endolymphatic hydrops in patients with Ménière's disease. Otol Neurotol 2011;32:472–7CrossRefGoogle ScholarPubMed
18Foster, CA, Breeze, RE.Endolymphatic hydrops in Ménière's disease: cause, consequence, or epiphenomenon? Otol Neurotol 2013;34:1210–14CrossRefGoogle ScholarPubMed
19Merchant, SN, Adams, JC, Nadol, JB Jr. Pathophysiology of Ménière's syndrome: are symptoms caused by endolymphatic hydrops? Otol Neurotol 2005;26:74–81CrossRefGoogle ScholarPubMed
20Alpay, HC, Linthicum, FH Jr. Endolymphatic hydrops without Ménière's disease. Otol Neurotol 2007;28:871–2CrossRefGoogle Scholar
21Ichimiya, I, Adams, JC, Kimura, RS.Changes in immunostaining of cochleas with experimentally induced endolymphatic hydrops. Ann Otol Rhinol Laryngol 1994;103:457–68Google ScholarPubMed
22Nadol, JB Jr, Adams, JC, Kim, JR.Degenerative changes in the organ of Corti and lateral cochlear wall in experimental endolymphatic hydrops and human Ménière's disease. Acta Otolaryngol Suppl 1995;519:47–59CrossRefGoogle ScholarPubMed
23Martin Gonzàlez, C, Gonzalez, FM, Trinidad, A, Ibáñez, A, Pinilla, M, Martínez Ruiz-Coello, A et al. Medical management of Ménière's disease: a 10-year case series and review of literature. Eur Arch Otorhinolaryngol 2010;267:1371–6CrossRefGoogle ScholarPubMed
24Burgess, A, Kundu, S.Diuretics for Ménière's disease or syndrome. Cochrane Database Syst Rev 2006;(3):CD003599CrossRefGoogle Scholar
25Stason, WB, Cannon, PJ, Heinemann, HO, Laragh, JH.Furosemide. A clinical evaluation of its diuretic action. Circulation 1966;34:910–20CrossRefGoogle ScholarPubMed
26Pike, DA, Bosher, K.The time course of the strial changes produced by intravenous furosemide. Hear Res 1980;3:79–89CrossRefGoogle ScholarPubMed
27Santi, PA, Lakhani, B.The effect of bumetanide on the stria vascularis: a stereological analysis of cell volume density. Hear Res 1983;12:151–65CrossRefGoogle ScholarPubMed
28Fiorino, F, Pizzini, FB, Barbieri, F, Beltramello, A.Magnetic resonance imaging fails to show evidence of reduced endolymphatic hydrops in gentamicin treatment of Ménière's disease. Otol Neurotol 2012;33:629–33CrossRefGoogle ScholarPubMed
29Gurkov, R, Flatz, W, Keeser, D, Strupp, M, Ertl-Wagner, B, Krause, E.Effect of standard-dose betahistine on endolymphatic hydrops: an MRI pilot study. Eur Arch Otorhinolaryngol 2013;270:1231–5CrossRefGoogle ScholarPubMed
30Gurkov, R, Flatz, W, Louza, J, Strupp, M, Ertl-Wagner, B, Krause, E.In vivo visualized endolymphatic hydrops and inner ear functions in patients with electrocochleographically confirmed Ménière's disease. Otol Neurotol 2012;33:1040–5CrossRefGoogle ScholarPubMed
31Vasama, JP, Linthicum, FH Jr. Ménière's disease and endolymphatic hydrops without Ménière's symptoms: temporal bone histopathology. Acta Otolaryngol 1999;119:297–301Google ScholarPubMed
32Uno, A, Imai, T, Watanabe, Y, Tanaka, H, Kitahara, T, Horii, A et al. Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI. Acta Otolaryngol 2013;133:924–9CrossRefGoogle ScholarPubMed
33Foster, CA, Breeze, RE.The Ménière attack: an ischemia/reperfusion disorder of inner ear sensory tissues. Med Hypotheses 2013;81:1108–15CrossRefGoogle ScholarPubMed
34Kimura, R.Experimental endolymphatic hydrops. In: Harris, JP, ed. Ménière's Disease. The Hague: Kugler Publications, 1999;115–24Google Scholar
35Miller, JM, Ren, TY, Nuttall, AL.Studies of inner ear blood flow in animals and human beings. Otolaryngol Head Neck Surg 1995;112:101–13Google ScholarPubMed
36Nakashima, T.Autoregulation of cochlear blood flow. Nagoya J Med Sci 1999;62:1–9Google ScholarPubMed
37Pirodda, A, Ferri, GG, Raimondi, MC, Borghi, C.Diuretics in Ménière disease: a therapy or a potential cause of harm? Med Hypotheses 2011;77:869–71CrossRefGoogle ScholarPubMed