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Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study

Published online by Cambridge University Press:  27 November 2019

B H K Ng ,
I P Tang ,
P Narayanan ,
R Raman  and
R L Carrau
B H K Ng
Affiliation:
Otorhinolaryngology – Head and Neck Surgery Department, Faculty of Medicine, University of Malaya, Malaysia Otorhinolaryngology – Head and Neck Surgery Department, Faculty of Medicine and Health Sciences, University Malaysia Sarawak, Malaysia Otorhinolaryngology – Head and Neck Surgery Department, Sarawak General Hospital, Malaysia
I P Tang*
Affiliation:
Otorhinolaryngology – Head and Neck Surgery Department, Faculty of Medicine and Health Sciences, University Malaysia Sarawak, Malaysia Otorhinolaryngology – Head and Neck Surgery Department, Sarawak General Hospital, Malaysia
P Narayanan
Affiliation:
Otorhinolaryngology – Head and Neck Surgery Department, Faculty of Medicine, University of Malaya, Malaysia
R Raman
Affiliation:
Otorhinolaryngology – Head and Neck Surgery Department, Faculty of Medicine, University of Malaya, Malaysia
R L Carrau
Affiliation:
Otorhinolaryngology – Head and Neck Surgery Department, Ohio State University Wexner Medical Center, Columbus, Ohio, USA
*
Author for correspondence: Dr Ing Ping Tang, Otorhinolaryngology – Head and Neck Surgery Department, Faculty of Medicine and Health Sciences, University Malaysia Sarawak (‘UNIMAS’), Jalan Datuk Mohd Musa, 94300Kota Samarahan, Sarawak, Malaysia E-mail: ingptang@yahoo.com
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Abstract

Background

Nasal lavage with mupirocin has the potential to reduce sinonasal morbidity in endoscopic endonasal approaches for skull base surgery.

Objective

To evaluate the effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery.

Methods

A pilot randomised, controlled trial was conducted on 20 adult patients who had undergone endoscopic endonasal approaches for skull base lesions. These patients were randomly assigned to cohorts using nasal lavages with mupirocin or without mupirocin. Patients were assessed in the out-patient clinic, one week and one month after surgery, using the 22-item Sino-Nasal Outcome Test questionnaire and nasal endoscopy.

Results

Patients in the mupirocin nasal lavage group had lower nasal endoscopy scores post-operatively, and a statistically significant larger difference in nasal endoscopy scores at one month compared to one week. The mupirocin nasal lavage group also showed better Sino-Nasal Outcome Test scores at one month compared to the group without mupirocin.

Conclusion

Nasal lavage with mupirocin seems to yield better outcomes regarding patients’ symptoms and endoscopic findings.

Keywords

Endoscopic Surgical ProcedureMinimally Invasive SurgerySkull BaseNasal LavageMupirocin
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 12 , December 2019 , pp. 1059 - 1063
Copyright
Copyright © JLO (1984) Limited, 2019

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Footnotes

Dr I P Tang takes responsibility for the integrity of the content of the paper

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