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Epithelial atypia and squamous metaplasia in nasal polyps

Published online by Cambridge University Press:  29 June 2007

A. R. Baird*
Affiliation:
Department of Pathology, Ninewells Hospital and Medical School, Dundee, Scotland.
O. Hilmi
Affiliation:
Department of Otorhinolaryngology, Ninewells Hospital and Medical School, Dundee, Scotland.
P. S. White
Affiliation:
Department of Otorhinolaryngology, Ninewells Hospital and Medical School, Dundee, Scotland.
A. J. Robertson
Affiliation:
Department of Pathology, Ninewells Hospital and Medical School, Dundee, Scotland.
*
Address for correspondence: Dr A. R. Baird, Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY. Fax: 01382 640966

Abstract

Fifteen routine nasal polypectomy specimens submitted to our laboratory over an eight-month period were noted to show marked atypia within areas of squamous metaplasia to a degree suggestive of dysplasia. Reviewing the literature revealed little published work in this area, especially recently. Further nasal polyp cases from this, and a similar previous time period, were re-examined, and possible causes for these changes discussed.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 1998

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References

Bushwald, C., Franzmann, M. B., Jacobsen, G. K., Lindeberg, H. (1994) Human papillomavirus and normal nasal mucosa detection of human papillomavirus DNA in normal nasal mucosa biopsies by polymerase chain reaction and insitu hybridization. Laryngoscope 104: 755757.CrossRefGoogle Scholar
Calderon-Garciduenas, L., Osorno-Velazquez, A., Bravo-Alvarez, H., Delgado-Chavez, R., Barrios-Marquez, R. (1992) Histopathological changes of the nasal mucosa in Southwest Metropolitan Mexico City inhabitants. American Journal of Pathology 140: 225232.Google ScholarPubMed
Crissman, J. D., Zarbo, R. J. (1989) Dysplasia, in situ carcinoma and progression to invasive squamous cell carcinoma of the upper aerodigestive tract. American Journal of Surgical Pathology 13: 516.Google ScholarPubMed
Friedmann, I., Osborne, D. (1982) Miscellaneous granulomas andnasal polyps. In Pathology of Granulomas and Neoplasms of the Nose and Paranasal Sinuses. Churchill Livingstone, Edinburgh, pp 2835.Google Scholar
Gaafar, H., Girgis, R., Hussein, M., El-Nemo, F. (1992) The effect of ammonia on the respiratory nasal mucosa of mice. Acta Otolaryngologica (Stockh) 112: 339342.CrossRefGoogle ScholarPubMed
Hellquist, H., Irander, K., Edling, C. H., Odkvist, L. M (1983) Nasal symptoms and histopathology in a group of spraypainters. Acta Otolaryngologica 96: 495500.CrossRefGoogle Scholar
Kunze, E., Schauer, A., Schatt, S. (1976) Stages of transformation in the development of N-butyl-N-(4 hydroxybutyl) nitrocamine-induced transitional cell carcinoma in the urinary bladder of rats Zeitschrift fur Krebsforschung und Klinische Ohkologie – Cancer Research and Clinical Oncology 87: 139.Google ScholarPubMed
Torjusson, W., Solberg, L. A., Hogetiriet, A. C. (1979) Histopathologic changes of nasal mucosa in nickel workers. Cancer 44: 963974.3.0.CO;2-H>CrossRefGoogle Scholar