Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-28T02:06:10.907Z Has data issue: false hasContentIssue false
  • English
  • Français

Expression of Fos-protein activated by tactile stimulation on the laryngeal vestibulum in the cat's lower brain stem

Published online by Cambridge University Press:  29 June 2007

Yasumasa Tanaka ,
Yoshikazu Yoshida  and
Minoru Hirano
Yasumasa Tanaka*
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, School of Medicine, Kurume University, Kurume, Japan.
Yoshikazu Yoshida
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, School of Medicine, Kurume University, Kurume, Japan.
Minoru Hirano
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, School of Medicine, Kurume University, Kurume, Japan.
*
Address for correspondence: Yasumasa Tanaka, M.D., Department of Otorhinolaryngology and Head and Neck Surgery, School of Medicine, Kurume University, 67 Asahimachi, Kurume, 830, Japan Fax: 81-942-37-1200.
Get access Rights & Permissions [Opens in a new window]

Abstract

To demonstrate morphologically the neurons participating in the4aryngeal reflex, Fos-expression, activated with tactile stimulation of the laryngeal vestibulum, was mapped in the cat's lower brain stem utilizing immunohistochemistry. In the stimulation group, many Fos-immunoreactive (ir) neurons were recognized in the nucleus tractus solitarii (NTS) from the level of the most rostral portion of the dorsal motor nucleus of the vagus to the level of the most caudal portion of the inferior olivary nucleus (IO), and in the nucleus ambiguus (NA) from the level of the rostral end of the hypoglossal nucleus to the level of the caudal end of the IO, bilaterally. While some Fos-ir cells were found in the spinal nucleus of the trigeminus, they were also found in the reticular nuclei bilaterally. In the control group, Fos-ir cells were distinctly fewer in number than those in the stimulation group. The results suggested that in the brain stem, the laryngeal reflex pathways have more than two synaptic relays through the interneurons in between the NTS and the NA.

Keywords

Proto-oncogene proteins c-FosImmunohistochemistryStimulation, tactileBrain stemCat
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 1 , January 1995 , pp. 39 - 44
Copyright
Copyright © JLO (1984) Limited 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Anonsen, C. K., Lalakea, M. L., Hannley, M. (1989) Laryngeal brain stem evoked response. Annals of Otology, Rhinology and Laryngology 98: 677–683.CrossRefGoogle ScholarPubMed
Astrom, K. E. (1953) On the central course of afferent fibers in the trigeminal, facial, glossopharyngeal, and vagal nerves and their nuclei in the mouse. Acta Physiologica Scandinavica 106(suppl. 29): 209–320.CrossRefGoogle Scholar
Beckstead, R. M., Norgren, R. (1979) An autoradiographic examination of the central distribution of the trigeminal, facial, glossopharyngeal, vagal nerves in the monkey. Journal of Comparative Neurology 184: 455–472.CrossRefGoogle ScholarPubMed
Berger, A. J., Averill, D. B., Cameron, W. E. (1984) Morphology of inspiratory neurons located in the ventrolateral nucleus of the tractus solitarius of the cat. Journal of Comparative Neurology 224: 60–70.CrossRefGoogle ScholarPubMed
Cohen, S., Esclamado, R. M., Telian, S. (1993) Laryngeal brain stem evoked response in the porcine model. Annals of Otology, Rhinology and Laryngology 102: 28–34.CrossRefGoogle ScholarPubMed
Cottle, M. K., Calaresu, F. R. (1975) Projections from the nucleus and tractus solitarius in the cat. Journal of Comparative Neurology 161: 143–158.CrossRefGoogle Scholar
Davis, P. J., Nail, B. S. (1984) On the location and size of laryngeal motoneurons in the cat and rabbit. Journal of Comparative Neurology 230: 13–32.CrossRefGoogle Scholar
Gacek, R. R. (1975) Localization of laryngeal motor neurons in the kitten. Laryngoscope 86: 1841–1861.CrossRefGoogle Scholar
Greenberg, M. E., Ziff, E. B., Greene, L. A. (1986) Stimulation of neuronal acetylcholine receptors induces rapid gene transcription. Science 234: 80–83.CrossRefGoogle ScholarPubMed
Hunt, S. P., Pini, A., Evan, G. (1987) Induction of c-Fos-like protein in spinal cord neurons following sensory stimulation. Nature 328: 623–624.CrossRefGoogle ScholarPubMed
Isogai, Y., Suzuki, M., Saitou, S. (1987) Brain stem response evoked by the laryngeal reflex. In Neurolaryngology: Recent Advances (Hirano, M., Kirchner, J. A., Bless, D. M., eds.). A College-Hill Publication, Boston, pp 167–183.Google Scholar
Kalia, M., Feldman, J. L., Cohen, M. I. (1979) Afferent projections to the inspiratory neuronal region of the ventrolateral nucleus of the tractus solitarius in the cat. Brain Research 171: 135–141.CrossRefGoogle Scholar
Kalia, M., Mesulam, M. M. (1980) Brain stem projections of sensory and motor components of the vagus complex in the cat. II: Laryngeal, tracheobronchial, pulmonary, cardiac and gastrointestinal branches. Journal of Comparative Neurology 193: 467–508.CrossRefGoogle ScholarPubMed
Kerr, F. W. L. (1963) The divisional organization of afferent fibers of the trigeminal nerve. Brain 86: 721–732.CrossRefGoogle ScholarPubMed
Kirchner, J. A., Suzuki, M. (1968) Laryngeal reflex and voice production. Annals of the New York Academy of Sciences 155: 98–109.CrossRefGoogle Scholar
Lawn, A. M. (1966) The localization, in the nucleus ambiguus of the rabbit, of the cells of origin of motor nerve fibers in the glossopharyngeal nerve and various branches of the vagus nerve by means of retrograde degeneration. Journal of Comparative Neurology 127: 293–306.CrossRefGoogle ScholarPubMed
Loewy, A. D., Burton, H. (1978) Nuclei of the solitary tract: efferent projections to the lower brain stem and spinal cord of the cat. Journal of Comparative Neurology 181: 421–450.CrossRefGoogle Scholar
Martensson, A. (1963) Reflex responses and recurrent discharges evoked by stimulation of laryngeal nerves. Acta Physiologica Scandinavica 57: 248–269.CrossRefGoogle Scholar
Menetrey, D., Gannon, A., Levine, J. D., Basbaum, A. I. (1989) Expression of c-Fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. Journal of Comparative Neurology 285: 177–195.CrossRefGoogle ScholarPubMed
Merill, E. G. (1970) The lateral respiratory neurons of the medulla: their associations with nucleus ambiguus, nucleus retroambigualis, the spinal accessory nucleus and the spinal cord. Brain Research 24: 11–28.CrossRefGoogle Scholar
Mitsumasu, T. (1984) Afferent projections to the nucleus ambiguus in the cat. Otologia (Fukuoka) 30: 1106–1134.Google Scholar
Morest, D. K. (1967) Experimental study of the projections of the nucleus of the tractus solitarius and the area postrema in the cat. Journal of Comparative Neurology 130: 277–300.CrossRefGoogle ScholarPubMed
Morgan, J. I., Curran, T. (1991) Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes Fos and Jun. Annual Review of Neuroscience 14: 421–441.CrossRefGoogle ScholarPubMed
Nomura, S., Mizuno, N. (1983) Central distribution of efferent and afferent components of the cervical branches of the vagus nerve. Anatomy and Embryology 166: 1–18.CrossRefGoogle ScholarPubMed
Norgren, R. (1978) Projections from the nucleus of the solitary tract in the rat. Neuroscience 3: 207–218.CrossRefGoogle ScholarPubMed
Rouiller, E. M., Wan, X. S. T., Moret, V., Liang, F. (1992) Mapping of c-Fos expression elicited by pure tone stimulation in the auditory pathways of the rat with emphasis on the cochlear nucleus. Neuroscience 144: 19–24.Google Scholar
Suzuki, M., Kirchner, J. A. (1969) Sensory fibers in the recurrent laryngeal nerve. Annals of Otology, Rhinology and Laryngology 78: 21–31.CrossRefGoogle ScholarPubMed
Suzuki, M. (1987) Laryngeal reflexes. In Neurolaryngology: Recent Advances. (Hirano, M., Kirchner, J. A., Bless, D. M., eds.). A College-Hill Publication, Boston, pp 142–155.Google Scholar
Szentagothai, J. (1943) Die Lokalisation der Kehlkopfmuskulatur in den Vaguskernen. Zeitschrift Fuer Anatomie 112: 704–710.Google Scholar
Tanaka, Y., Yoshida, Y., Hirano, M., Morimoto, M., Kanaseki, T. (1987) Distribution of sensory nerve fibers in the larynx and pharynx: An HRP study in cats. In Neurolaryngology: Recent Advances. (Hirano, M., Kirchner, J. A., Bless, D. M., eds.), A College-Hill Publication, Boston, pp 27–45.Google Scholar
Yoshida, Y., Miyazaki, T., Hirano, M., Shin, T, Kanaseki, T. (1982) Arrangement of motorneurons innervating the intrinsic laryngeal muscles of cats as demonstrated by horseradish peroxidase. Acta Otolaryngologica 94: 329–334.CrossRefGoogle Scholar
Yoshida, Y., Tanaka, Y., Mitsumasu, T., Hirano, M., Kanaseki, T. (1986) Peripheral course and intramucosal distribution of the laryngeal sensory nerve fibers of cats. Brain Research Bulletin 17: 95–105.CrossRefGoogle ScholarPubMed