Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-27T16:37:00.619Z Has data issue: false hasContentIssue false
  • English
  • Français

Influence of lipoproteins and fibrinogen on pathogenesis of sudden sensorineural hearing loss

Published online by Cambridge University Press:  05 November 2010

Z Oreskovic ,
D Shejbal ,
G Bicanic  and
B Kekic
Z Oreskovic
Affiliation:
Department of Anesthesiology and Intensive Care, Clinical Hospital Center Zagreb, Zagreb, Croatia
D Shejbal
Affiliation:
Department of Otorhinolaryngology, City Hospital Pakrac, Zagreb, Croatia
G Bicanic*
Affiliation:
University Clinic for Orthopedic Surgery, Clinical Hospital Center Zagreb, Zagreb, Croatia
B Kekic
Affiliation:
University Clinic for Otorhinolaryngology, Sestre Milosrdnice Clinical Hospital, Zagreb, Croatia
*
Address for correspondence: Dr Goran Bicanic, University Clinic for Orthopedic Surgery, Clinical Hospital Center Zagreb, Salata 6-7, 10000 Zagreb, Croatia Fax: +385 1 4818810 E-mail: gbic@mef.hr
Get access Rights & Permissions [Opens in a new window]

Abstract

Aim:

To evaluate the relationship between lipoproteins, fibrinogen and sudden sensorineural hearing loss in a Croatian population. Since pathological derangement of lipoproteins and fibrinogen could be one of the causes of sudden sensorineural hearing loss, we hypothesised that patients with sudden sensorineural hearing loss would have more abnormal fibrinogen and lipoprotein concentrations, compared with subjects with normal hearing.

Methods:

Plasma concentrations of cholesterol, fibrinogen and triglycerides in patients with sudden sensorineural hearing loss were compared with those in a control group (i.e. subjects with normal hearing function).

Results:

Patients with sudden sensorineural hearing loss had significantly higher plasma concentrations of cholesterol and low density lipoprotein cholesterol, compared with controls.

Conclusion:

Higher cholesterol and low density lipoprotein cholesterol concentrations were found in patients with sudden sensorineural hearing loss, within a Croatian population. Cholesterol and low density lipoprotein cholesterol concentrations may be important factors in the pathogenesis of sudden sensorineural hearing loss, and should be assessed during the investigation of patients with this condition.

Keywords

Sudden Hearing LossCholesterolLow Density Lipoprotein CholesterolFibrinogenTriglyceridesAtherosclerosisHearing LossCroatia
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 3 , March 2011 , pp. 258 - 261
Copyright
Copyright © JLO (1984) Limited 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Harris, JP, Ruckenstein, MJ. Sudden sensorineural hearing loss, perilymph fistula, and autoimmune inner ear disease. In: Ballenger, J, Snow, J Jr, eds. Otorhinolaryngology: Head and Neck Surgery. Baltimore: Williams & Wilkins, 1996;1109–18Google Scholar
2Mattox, DE, Simmons, FB. Natural history of sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol 1977;86:463–80Google Scholar
3Suckfull, M. Fibrinogen and LDL apheresis in treatment of sudden hearing loss: a randomised multicentre trial. Lancet 2002;360:1811–17CrossRefGoogle ScholarPubMed
4Alexiou, C, Arnold, W, Fauser, C, Schratzenstaller, B, Gloddek, B, Fuhrmann, S et al. Sudden sensorineural hearing loss: does application of glucocorticoids make sense? Arch Otolaryngol Head Neck Surg 2001;127:253–8CrossRefGoogle ScholarPubMed
5Moskowitz, D, Lee, KJ, Smith, HW. Steroid use in idiopathic sudden sensorineural hearing loss. Laryngoscope 1984;94:664–6CrossRefGoogle ScholarPubMed
6Libby, P. The pathogenesis, prevention, and treatment of atherosclerosis. In: Fauci, AS, Kasper, DL, Longo, DL, Braunwald, E, Hauser, SL, Jameson, JL et al. , eds. Harrison's Principles of Internal Medicine, 17th edn.New York: McGraw-Hill, 2008;966–73Google Scholar
7Rudack, C, Langer, C, Stoll, W, Rust, S, Walter, M. Vascular risk factors in sudden hearing loss. Thromb Haemost 2006;95:454–61CrossRefGoogle ScholarPubMed
8Nguyen, TV, Brownell, WE. Contribution of membrane cholesterol to outer hair cell lateral wall stiffness. Otolaryngol Head Neck Surg 1998;119:14–20CrossRefGoogle ScholarPubMed
9Suzuki, K, Kaneko, M, Murai, K. Influence of serum lipids on auditory function. Laryngoscope 2000;110:1736–8CrossRefGoogle ScholarPubMed
10Fessenden, JD, Schacht, J. The nitric oxide/cyclic GMP pathway: a potential major regulator of cochlear physiology. Hear Res 1998;118:168–76CrossRefGoogle ScholarPubMed
11Ohinata, Y, Makimoto, K, Kawakami, M, Haginomori, S, Araki, M, Takahashi, H. Blood viscosity and plasma viscosity in patients with sudden deafness. Acta Otolaryngol 1994;114:601–7CrossRefGoogle ScholarPubMed
12Reiner, Z. Lipids and cardiovascular diseases [in Croatian]. Lijec Vjesn 1990;112:243–9Google ScholarPubMed
13Turek, S, Rudan, I, Smolej-Narancic, N, Szirovicza, L, Cubrilo-Turek, M, Zerjavic-Hrabak, V et al. A large cross-sectional study of health attitudes, knowledge, behaviour and risks in the post-war Croatian population (the First Croatian Health Project). Coll Antropol 2001;25:77–96http://www.ncbi.nlm.nih.gov/pubmed/11787568Google ScholarPubMed
14Balletshofer, BM, Stock, J, Rittig, K, Lehn-Stefan, A, Braun, N, Burkart, F et al. Acute effect of rheopheresis on peripheral endothelial dysfunction in patients suffering from sudden hearing loss. Ther Apher Dial 2005;9:385–90CrossRefGoogle ScholarPubMed