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Investigation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus

Published online by Cambridge University Press:  15 January 2018

B Ulusoy ,
K Bozdemir ,
M Akyol ,
H İ Mişe ,
A Kutluhan  and
M H Korkmaz
B Ulusoy*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Selçuk University, Konya, Turkey
K Bozdemir
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey
M Akyol
Affiliation:
Department of Biostatistics, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey
H İ Mişe
Affiliation:
Department of Otorhinolaryngology, Kaçkar State Hospital, Rize, Turkey
A Kutluhan
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey
M H Korkmaz
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey
*
Address for correspondence: Dr Bülent Ulusoy, Department of Otorhinolaryngology, Faculty of Medicine, Selçuk University, Konya 42075, Turkey Fax: +90 332 241 2184 E-mail: ulusoybulent@hotmail.com
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Abstract

Objective:

This study aimed to evaluate patients with tinnitus in terms of mean platelet volume and platelet distribution width, and to explore neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio, recently reported in the literature as being possible inflammation markers.

Methods:

This study comprised 64 tinnitus patients and 64 age-matched healthy controls. Statistical significance level was accepted as p < 0.05.

Results:

Mean platelet volume (t = 3.245, p = 0.002) and platelet distribution width (Z = 3.945, p < 0.001) were significantly higher in the patient group than the control group.

Conclusion:

The results suggest that a prothrombotic condition might play a role in the pathophysiology of tinnitus.

Keywords

Mean Platelet VolumeTinnitusClinical MarkerInflammationThrombosis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 2 , February 2018 , pp. 129 - 132
Copyright
Copyright © JLO (1984) Limited 2018 

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References

1 Schecklmann, M, Lehner, A, Poeppl, TB, Kreuzer, PM, Rupprecht, R, Rackl, J et al. Auditory cortex is implicated in tinnitus distress: a voxel-based morphometry study. Brain Struct Funct 2013;218:1061–70Google Scholar
2 Sanchez, TG, Rocha, CB. Diagnosis and management of somatosensory tinnitus: review article. Clinics (Sao Paulo) 2011;66:1089–94Google Scholar
3 Seidman, MD, Standring, RT, Dornhoffer, JL. Tinnitus: current understanding and contemporary management. Curr Opin Otolaryngol Head Neck Surg 2010;18:363–8Google Scholar
4 Chen, Y, Xiao, Y, Lin, Z, Xiao, X, He, C, Bihl, JC et al. The role of circulating platelets microparticles and platelet parameters in acute ischemic stroke patients. J Stroke Cerebrovasc Dis 2015;24:2313–20Google Scholar
5 Martin, JF, Trowbridge, EA, Salmon, G, Plumb, J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983;32:443–60Google Scholar
6 Vagdatli, E, Gounari, E, Lazaridou, E, Katsibourlia, E, Tsikopoulou, F, Labrianou, I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14:28–32 Google Scholar
7 Seo, YJ, Jeong, JH, Choi, JY, Moon, IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers 2014;2014:702807 Google Scholar
8 Ulu, S, Ulu, MS, Bucak, A, Ahsen, A, Yucedag, F, Aycicek, A. Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2013;34:1400–4Google Scholar
9 Faul, F, Erdfelder, E, Lang, A, Buchner, A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007;39:175–91Google Scholar
10 Sevuk, U, Bahadir, MV, Altindag, R, Baysal, E, Yaylak, B, Ay, N et al. Value of serial platelet indices measurements for the prediction of pulmonary embolism in patients with deep venous thrombosis. Ther Clin Risk Manag 2015;11:1243–9Google Scholar
11 Yilmaz, MB, Cihan, G, Guray, Y, Guray, U, Kisacik, HL, Sasmaz, H et al. Role of mean platelet volume in triagging acute coronary syndromes. J Thromb Thrombolysis 2008;26:49–54 Google Scholar
12 Kamisli, O, Kamisli, S, Kablan, Y, Gonullu, S, Ozcan, C. The prognostic value of an increased mean platelet volume and platelet distribution width in the early phase of cerebral venous sinus thrombosis. Clin Appl Thromb Hemost 2013;19:29–32 Google Scholar
13 Sarıkaya, Y, Bayraktar, C, Karatas, M, Dogan, S, Olt, S, Kaskalan, E et al. Increased mean platelet volume in patients with idiopathic subjective tinnitus. Eur Arch Otorhinolaryngol 2016;273:3533–6Google Scholar
14 Kemal, O, Muderris, T, Basar, F, Kutlar, G, Gul, F. Prognostic value of mean platelet volume on tinnitus. J Laryngol Otol 2016;130:162–5Google Scholar
15 Yuksel, F, Karatas, D. Can platelet indices be new biomarkers for subjective tinnitus? J Craniofac Surg 2016;27:e420–4 Google Scholar
16 Bayram, A, Yaşar, M, Doğan, M, Güneri, E, Özcan, İ. Assessment of neutrophil-to lymphocyte ratio, platelet-to lymphocyte ratio and mean platelet volume in patients with tinnitus. ENT Updates 2015;5:103–6Google Scholar
17 Özbay, I, Kahraman, C, Balikci, HH, Kucur, C, Kahraman, NK, Ozkaya, DP et al. Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: prospective, controlled clinical study. J Laryngol Otol 2015;129:544–7CrossRefGoogle ScholarPubMed