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Management of locally advanced T3–4 glottic laryngeal carcinomas

Published online by Cambridge University Press:  02 July 2018

R Smee ,
J R Williams  and
D P Kotevski
R Smee
Affiliation:
Department of Radiation Oncology, Prince of Wales Cancer Centre, Randwick, New South Wales, Australia UNSW Clinical Teaching School, Prince of Wales Hospital, Randwick, New South Wales, Australia Department of Radiation Oncology, Tamworth Base Hospital, New South Wales, Australia
J R Williams*
Affiliation:
Department of Radiation Oncology, Prince of Wales Cancer Centre, Randwick, New South Wales, Australia UNSW Clinical Teaching School, Prince of Wales Hospital, Randwick, New South Wales, Australia
D P Kotevski
Affiliation:
Department of Radiation Oncology, Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
*
Author for correspondence: Dr Janet R Williams, Department of Radiation Oncology, Prince of Wales Cancer Centre, Level 2 High Street, Randwick, NSW 2031, Australia E-mail: Janet.Williams@health.nsw.gov.au Fax: +61 2 9382 5170
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Abstract

Objectives

To assess five-year local control and ultimate local control rates of patients treated for locally advanced T3–4 glottic carcinoma with surgery only, radiotherapy only, or surgery plus radiotherapy. Cancer-specific survival, overall survival and rates of malignancy development were also assessed.

Methods

A retrospective review was conducted on patients from 1967 to 2015, with analysis of local control, ultimate local control, overall survival and cancer-specific survival performed using Kaplan–Meier and Cox regression.

Results

Of 169 eligible patients, the majority (59 per cent) were treated with surgery plus radiotherapy, with laryngectomy being the most common surgical procedure. Local control and ultimate local control rates were higher with surgery only (94.1 per cent) and surgery plus radiotherapy (87.9 and 86.8 per cent respectively), compared to radiotherapy only (46.8 and 52.4 per cent) (both p < 0.001). Cancer-specific survival, overall survival and malignancy development did not differ between groups.

Conclusion

Surgery, with or without radiotherapy, offers significantly higher five-year local control and ultimate local control for patients with advanced glottic carcinoma, compared to radiotherapy only.

Keywords

GlottisTNM StagingSquamous Cell CarcinomaTreatment OutcomesRecurrence
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 7 , July 2018 , pp. 642 - 650
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr J R Williams takes responsibility for the integrity of the content of the paper

References

1Mendenhall, WM, Hinerman, RW, Amdur, RJ, Mancuso, AA, Villaret, DB, Werning, JW. Larynx. In: Halperin, E, Perez, C, Brady, L, eds. Principles and Practice of Radiation Oncology, 5th edn. Philadelphia: Lippincott Williams & Wilkins, 2008;975–95Google Scholar
2Hartl, DM, Ferlito, A, Brasnu, DF, Langendijk, JA, Rinaldo, A, Silver, CE et al. Evidence-based review of treatment options for patients with glottic cancer. Head Neck 2011;33:1638–48Google Scholar
3Gourin, CG, Conger, BT, Sheils, WC, Bilodeau, PA, Coleman, TA, Porubsky, ES. The effect of treatment on survival in patients with advanced laryngeal carcinoma. Laryngoscope 2009;119:1312–17Google Scholar
4Timmermans, AJ, de Gooijer, CJ, Hamming-Vrieze, O, Hilgers, FJ, van den Brekel, MW. T3-T4 laryngeal cancer in The Netherlands Cancer Institute; 10-year results of the consistent application of an organ-preserving/-sacrificing protocol. Head Neck 2015;37:1495–503Google Scholar
5Reizenstein, JA, Holmberg, L, Bergqvist, M, Linder, A, Ekman, S, Lödén, B et al. Time trends in T3 to T4 laryngeal cancer: a population-based long-term analysis. Head Neck 2014;36:1727–31Google Scholar
6Lima, RA, Freitas, EQ, Dias, FL, Barbosa, MM, Kligerman, J, Soares, JR et al. Supracricoid laryngectomy with cricohyoidoepiglottopexy for advanced glottic cancer. Head Neck 2006;28:481–6Google Scholar
7Spector, GJ, Sessions, DG, Lenox, J, Newland, D, Simpson, J, Haughey, BH. Management of stage IV glottic carcinoma: therapeutic outcomes. Laryngoscope 2004;114:1438–46Google Scholar
8Chen, AY, Schrag, N, Hao, Y, Flanders, DW, Kepner, J, Stewart, A et al. Changes in treatment of advanced laryngeal cancer 1985–2001. Otolaryngol Head Neck Surg 2006;135:831–7Google Scholar
9BMJ Best Practice: laryngeal cancer. In: http://bestpractice.bmj.com/best-practice/monograph-pdf/1115.pdf [19 July 2017]Google Scholar
10Pfister, DG, Laurie, SA, Weinstein, GS, Mendenhall, WM, Adelstein, DJ, Ang, KK et al. American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 2006;24:3693–704Google Scholar
11Hoffman, HT, Porter, K, Karnell, LH, Cooper, JS, Weber, RS, Langer, CJ et al. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope 2006;116:1–13Google Scholar
12Al-Gilani, M, Skillington, S, Kallogjeri, D, Haughey, B, Piccirillo, JF. Surgical vs nonsurgical treatment modalities for T3 glottic squamous cell carcinoma. JAMA Otolaryngol Head Neck Surg 2016;142:940–6Google Scholar
13Hristov, B, Bajaj, GK. Radiotherapeutic management of laryngeal carcinoma. Otolaryngol Clin North Am 2008;41:715–40Google Scholar
14Sobin, LH, Gospodarowiczm, MK, Wittekind, C, eds. International Union Against Cancer: TNM Classification of Malignant Tumours, 7th edn. New Jersey: Wiley-Blackwell, 2009Google Scholar
15The Ryerson Index to death notices and obituaries in Australian newspapers. In: https://www.ryersonindex.org/ [23 May 2018]Google Scholar
16Chen, SA, Muller, S, Chen, AY, Hudgins, PA, Shin, DM, Khuri, F et al. Patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers. Cancer 2011;117:5047–51Google Scholar
17Mendenhall, WM, Parsons, JT, Mancuso, AA, Pameijer, FJ, Stringer, SP, Cassisi, NJ. Definitive radiotherapy for T3 squamous cell carcinoma of the glottic larynx. J Clin Oncol 1997;15:2394–402Google Scholar
18Furusaka, T, Matsuda, A, Tanaka, A, Matsuda, H, Ikeda, M. Superselective intra-arterial chemoradiation therapy for functional laryngeal preservation in advanced squamous cell carcinoma of the glottic larynx. Acta Otolaryngol 2013;133:633–40Google Scholar
19Kada, S, Hirano, S, Tateya, I, Kitamura, M, Ishikawa, S, Kanda, T et al. Ten years single institutional experience of treatment for advanced laryngeal cancer in Kyoto University. Acta Otolaryngol Suppl 2010;563:68–73Google Scholar
20Delaere, P, Goeleven, A, Poorten, VV, Hermans, R, Hierner, R, Vranckx, J. Organ preservation surgery for advanced unilateral glottic and subglottic cancer. Laryngoscope 2007;117:1764–9Google Scholar
21Harris, BN, Bhuskute, AA, Rao, S, Farwell, DG, Bewley, AF. Primary surgery for advanced-stage laryngeal cancer: a stage and subsite-specific survival analysis. Head Neck 2016;38:1380–6Google Scholar
22Canis, M, Martin, A, Ihler, F, Wolff, HA, Kron, M, Matthias, C et al. Results of transoral laser microsurgery for supraglottic carcinoma in 277 patients. Eur Arch Otorhinolaryngol 2013;270:2315–26Google Scholar
23Canis, M, Ihler, F, Martin, A, Wolff, HA, Matthias, C, Steiner, W. Results of 226 patients with T3 laryngeal carcinoma after treatment with transoral laser microsurgery. Head Neck 2014;36:652–9Google Scholar
24Hinni, ML, Salassa, JR, Grant, DG, Pearson, BW, Hayden, RE, Martin, A et al. Transoral laser microsurgery for advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg 2007;133:1198–204Google Scholar
25Hinerman, RW, Mendenhall, WM, Morris, CG, Amdur, RJ, Werning, JW, Villaret, DB. T3 and T4 true vocal cord squamous carcinomas treated with external beam irradiation: a single institution's 35-year experience. Am J Clin Oncol 2007;30:181–5Google Scholar
26Al-Mamgani, A, Tans, L, van Rooij, P, Levendag, PC. A single-institutional experience of 15 years of treating T3 laryngeal cancer with primary radiotherapy, with or without chemotherapy. Int J Radiat Oncol Biol Phys 2012;83:1000–6Google Scholar
27MacKenzie, RG, Franssen, E, Balogh, JM, Gilbert, RW, Birt, D, Davidson, J. Comparing treatment outcomes of radiotherapy and surgery in locally advanced carcinoma of the larynx: a comparison limited to patients eligible for surgery. Int J Radiat Oncol Biol Phys 2000;47:65–71Google Scholar
28Croll, GA, Gerritsen, GJ, Tiwari, RM, Snow, GB. Primary radiotherapy with surgery in reserve for advanced laryngeal carcinoma. Results and complications. Eur J Surg Oncol 1989;15:350–6Google Scholar
29Lyhne, NM, Primdahl, H, Kristensen, CA, Andersen, E, Johansen, J, Andersen, LJ et al. The DAHANCA 6 randomized trial: effect of 6 vs 5 weekly fractions of radiotherapy in patients with glottic squamous cell carcinoma. Radiother Oncol 2015;117:91–8Google Scholar
30Forastiere, AA, Zhang, Q, Weber, RS, Maor, MH, Goepfert, H, Pajak, TF et al. Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol 2013;31:845–52Google Scholar
31Connor, KL, Pattle, S, Kerr, GR, Junor, E. Treatment, comorbidity and survival in stage III laryngeal cancer. Head Neck 2015;37:698–706Google Scholar
32Chen, AY, Fedewa, S, Pavluck, A, Ward, EM. Improved survival is associated with treatment at high-volume teaching facilities for patients with advanced stage laryngeal cancer. Cancer 2010;116:4744–52Google Scholar
33Kwok, J, Langevin, SM, Argiris, A, Grandis, JR, Gooding, WE, Taioli, E. The impact of health insurance status on the survival of patients with head and neck cancer. Cancer 2010;116:476–85Google Scholar
34Smee, RI, De-Loyde, KJ, Broadley, K, Williams, JR. Prognostic factors for supraglottic laryngeal carcinoma: importance of the unfit patient. Head Neck 2012;35:949–58Google Scholar
35Bøje, CR, Dalton, SO, Grønborg, TK, Primdahl, H, Kristensen, CA, Andersen, E et al. The impact of comorbidity on outcome in 12 623 Danish head and neck cancer patients: a population based study from the DAHANCA database. Acta Oncol 2013;52:285–93Google Scholar
36Vengalil, S, Giuliani, ME, Huang, SH, McNiven, A, Song, Y, Xu, W et al. Clinical outcomes in patients with T4 laryngeal cancer treated with primary radiotherapy versus primary laryngectomy. Head Neck 2016;38:E2035–40Google Scholar