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Oral squamous cell carcinoma and serum paraoxonase 1

Published online by Cambridge University Press:  11 November 2013

Z Boy Metin ,
S Aydin ,
M Unur ,
B Cakmakoglu ,
B Toptas ,
G Hafiz  and
T İsbir
Z Boy Metin
Affiliation:
Department of Oral Surgery and Medicine, Faculty of Dentistry, Istanbul University, Istanbul, Turkey
S Aydin*
Affiliation:
Department of Otorhinolaryngology, Bağcilar Research and Education Hospital, Istanbul, Turkey
M Unur
Affiliation:
Department of Oral Surgery and Medicine, Faculty of Dentistry, Istanbul University, Istanbul, Turkey
B Cakmakoglu
Affiliation:
Department of Molecular Medicine, Institute for Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey
B Toptas
Affiliation:
Department of Molecular Medicine, Institute for Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey
G Hafiz
Affiliation:
Department of Otolaryngology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
T İsbir
Affiliation:
Department of Molecular Medicine, Institute for Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey
*
Address for correspondence: Dr Salih Aydın, Bağcilar Eğitim Araştirma Hastanesi, Kulak Burun Boğaz Kliniği, Bağcilar, Istanbul, Turkey43200 E-mail: drsalihaydin@gmail.com
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Abstract

Background:

Serum paraoxonase 1 is involved in mechanisms that protect cells from oxidative stress damage. This study aimed to investigate the correlation between serum paraoxonase 1 activity and polymorphisms in patients with oral squamous cell carcinoma.

Methods and materials:

Fifty-seven patients with oral squamous cell carcinoma and 59 matched healthy controls participated in the study. Serum paraoxonase 1 activity and polymorphisms in blood samples were compared with results for polymerase chain reaction and restriction fragment length polymorphism tests.

Results:

Mean serum paraoxonase 1 activity levels were lower in patients than controls (mean ± standard deviation, 21.9 ± 5 units/l and 120.4 ± 2 units/l, respectively) (p = 0.001). The serum paraoxonase 1 192 glutamine polymorphism was more common in patients than controls.

Conclusion:

Patients with oral squamous cell carcinoma had significantly lower serum paraoxonase 1 activity levels and a greater prevalence of the serum paraoxonase 1 192 glutamine allele, compared with controls. Serum paraoxonase 1 may play a role in the aetiology of oral squamous cell carcinoma.

Keywords

ParaoxonasePolymorphism, GeneticOral CancerCarcinoma, Squamous CellGenes
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 12 , December 2013 , pp. 1208 - 1213
Copyright
Copyright © JLO (1984) Limited 2013 

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