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Ototoxicity of cis-platinum and its relationship to eye colour

Published online by Cambridge University Press:  29 June 2007

R. M. Barr-Hamilton ,
L. M. Matheson  and
D. G. Keay
R. M. Barr-Hamilton*
Affiliation:
Department of Audiology Department, Royal Infirmary of Edinburgh.
L. M. Matheson
Affiliation:
Department of Clinical Oncology, Western General Hospital, Edinburgh. Now at the Mount Vernon Centre for Cancer Treatment, Northwood.
D. G. Keay
Affiliation:
Department of Otolaryngology, Royal Infirmary of Edinburgh. Now at Ear, Nose and Throat Department, Stirling Royal Infirmary.
*
Dr R. M. Barr-Hamilton, Audiology Department, Royal Infirmary of Edinburgh, 39 Lauriston Place, Edinburgh EH3 9EN.
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Abstract

The following hypothesis is presented: that the susceptibility of an individual patient to hearing loss as a result of cis-platinum administration can be predicted on the basis of eye colour. The rationale is that the melanin content of the inner ears is related to that of the eyes; dark eyes contain more melanin than lightcoloured eyes; and melanin causes the accumulation of the ototoxic drug within the inner ear. Hence those with dark eyes will suffer greater damage to the hearing than those with pale eyes. An investigation that confirmed this hypothesis is reported. In addition to cochlear damage there is a significant likelihood of damage to the auditory nerve as a result of the treatment.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 1 , January 1991 , pp. 7 - 11
Copyright
Copyright © JLO (1984) Limited 1991

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