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Outcomes of synchronous pulmonary nodules detected on computed tomography in head and neck cancer patients: 12-year retrospective review of a consecutive cohort

Published online by Cambridge University Press:  15 March 2016

I Zammit-Maempel ,
R Kurien  and
V Paleri
I Zammit-Maempel*
Affiliation:
Department of Radiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
R Kurien
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
V Paleri
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
*
Address for correspondence: Dr Ivan Zammit-Maempel, Department of Radiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK Fax: 0191 223 1168 E-mail: ivan.zammit@nuth.nhs.uk
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Abstract

Objective:

To investigate the long-term outcomes of pulmonary nodules detected on chest computed tomography in a consecutive cohort of patients with newly diagnosed or recurrent head and neck squamous cell cancer staged between 2001 and 2003.

Results:

The study included 222 patients, 148 patients with newly diagnosed head and neck cancer (group 1) and 74 patients with recurrent cancer (group 2). Abnormalities were identified in 101 patients (45.4 per cent); these were predominantly benign in group 1 (61.7 per cent) as compared to predominantly malignant in group 2 (64.3 per cent) (Fisher's exact test; p = 0.0009). Only four patients (7.4 per cent) with an initially benign-looking pulmonary nodule went on to develop malignancy over time, conferring a negative predictive value of 93 per cent for the whole cohort.

Conclusion:

Chest computed tomography abnormalities in patients with recurrent head and neck cancer are statistically more likely to be malignant. Very few patients with an initially benign-appearing nodule develop chest malignancy over time.

Keywords

Pulmonary Nodules, SolitaryMultiple Pulmonary NodulesPrognosisComputerized Tomography, X-RayChestHead And Neck Cancer
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 6 , June 2016 , pp. 575 - 580
Copyright
Copyright © JLO (1984) Limited 2016 

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