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Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma

Published online by Cambridge University Press:  11 September 2012

T Nakashima ,
R Yasumatsu ,
M Masuda ,
G L Clayman  and
S Komune
T Nakashima*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Japan
R Yasumatsu
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Japan
M Masuda
Affiliation:
Department of Otolaryngology, Kyushu Koseinenkin Hospital, Kitakyushu City, Japan
G L Clayman
Affiliation:
Department of Head and Neck Surgery, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
S Komune
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Japan
*
Address for correspondence: Dr Torahiko Nakashima, Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan Fax: +81 92 6425685 E-mail: nakatora@qent.med.kyushu-u.ac.jp
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Abstract

Objective:

To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma.

Design:

Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival.

Results:

The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma.

Conclusion:

Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma.

Keywords

Oral CavitySquamous Cell CarcinomaCathepsinPathologyHeadpin Protein, Human
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 11 , November 2012 , pp. 1134 - 1137
Copyright
Copyright © JLO (1984) Limited 2012

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References

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