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Rhinitis symptoms and quality of life in patients with chronic perennial rhinitis treated with desloratadine

Published online by Cambridge University Press:  19 July 2007

H C K Lam ,
M C F Tong  and
C A Van Hasselt
H C K Lam*
Affiliation:
Division of Otorhinolaryngology, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
M C F Tong
Affiliation:
Division of Otorhinolaryngology, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
C A Van Hasselt
Affiliation:
Division of Otorhinolaryngology, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
*
Address for correspondence: Dr Henry Chuen Kwong Lam, Division of Otorhinolaryngology, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong. Fax: (852) 26466312 E-mail: henrycklam@yahoo.com.hk
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Abstract

Objective:

To evaluate the outcome and the change in quality of life of patients with chronic rhinitis after treatment with desloratadine.

Study design:

A prospective, open-label, non-blinded, non-randomised study of patients in a secondary and tertiary ENT referral centre.

Methods:

Chinese patients with chronic rhinitis were recruited. The patients were assessed by a questionnaire that included rhinitis symptoms score and SF-36 health survey components. Endoscopic assessment was performed with a rigid nasoendoscope and scored according to the modified endoscopic appearance score of Lund and Kennedy. A 12-week course of desloratadine 5 mg daily was prescribed. Patients were re-evaluated after treatment. A total of 47 subjects completed the study.

Results:

There were significant reductions in median rhinitis symptoms score, from six to five (p < 0.001), and in median endoscopic appearance score, from five to three (p < 0.001). Patients' general health perception was also improved after treatment (p == 0.022).

Conclusion:

Desloratadine may be an effective treatment which provides symptomatic relief and improves the quality of life in patients with chronic rhinitis.

Keywords

Perennial Allergic RhinitisAntihistaminesDesloratadine
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 121 , Issue 12 , December 2007 , pp. 1151 - 1155
Copyright
Copyright © JLO (1984) Limited 2007

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