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Sinonasal mucosal melanoma: retrospective survival study of 25 patients

Published online by Cambridge University Press:  29 September 2011

C Vandenhende ,
X Leroy ,
D Chevalier  and
G Mortuaire
C Vandenhende
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Huriez Hospital, University of Lille, France
X Leroy
Affiliation:
Department of Pathology, Huriez Hospital, University of Lille, France
D Chevalier
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Huriez Hospital, University of Lille, France
G Mortuaire*
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Huriez Hospital, University of Lille, France
*
Address for correspondence: Dr Geoffrey Mortuaire, Service d'ORL de Chirurgie Cervico-faciale, Pr Chevalier, CHRU Lille, 59000, France Fax: +33 320446220 E-mail: g-mortuaire@chru-lille.fr
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Abstract

Objective:

To determine potential prognostic factors for survival in patients with mucosal malignant melanoma of the sinonasal tract.

Methods:

Patients managed between 1991 and 2008 were assessed retrospectively. The seventh edition Union for International Cancer Control (7th UICC) tumour-node-metastasis classification was used for tumour staging. Kaplan–Meier and log rank tests were used for survival analysis.

Results:

Twenty-five patients were studied (six were tumour stage three, eight tumour stage four(a) and 11 tumour stage four(b)). Surgery was performed on 23 patients (92 per cent). Fifteen received post-operative radiotherapy. Mean follow up was 31.3 months (range, two to 99 months). Three-year disease-free survival was improved in patients with stage four tumour arising from the nasal fossa, versus other sites, and in those with stage four tumour treated with surgery plus adjuvant radiotherapy, versus other treatments.

Conclusion:

Patients with melanoma of the nasal cavity have very poor survival rates. Treatment is still based on adequate surgical resection with safe margins. In this study, post-operative radiotherapy improved local control only for stage four tumours.

Keywords

Nasal CavityParanasal SinusesMalignant MelanomaPrognosis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 2 , February 2012 , pp. 147 - 151
Copyright
Copyright © JLO (1984) Limited 2011

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