Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-27T10:38:30.094Z Has data issue: false hasContentIssue false
  • English
  • Français

Acute phase reactant proteins—an aid to monitoring surgical treatment of laryngeal carcinoma

Published online by Cambridge University Press:  29 June 2007

T. Krecicki  and
M. Leluk
T. Krecicki
Affiliation:
Wroclaw, Poland
M. Leluk*
Affiliation:
Wroclaw, Poland
*
Tomasz Krecicki, M.D., 51-607 Wroclaw, ul. Smolenskiego 4, Poland
Get access Rights & Permissions [Opens in a new window]

Abstract

The serum concentration of four acute phase reactant proteins (haptoglobin, sialic acid, α, 1-antitripsin, ceruloplasmin) were determined in 160 patients with laryngeal cancer. In 50 cases treated by surgery serial determinations were performed. The control group included healthy persons and patients with non-neoplastic diseases. The levels of haptoglobin, α 1-antitripsin and sialic acid were significantly higher in cancer patients than in control group. The levels of ceruloplasmin reveals no statistically significant difference between particular groups of patients. The serum concentrations of haptoglobin, α 1-antitripsin and sialic acid correlated with the clinical status of cancer patients. We suggest that serial determination of certain acute phase reactant proteins may be useful as a prognostic acid in following patients with laryngeal carcinoma.

Keywords

Acute phase proteinsLaryngeal neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 7 , July 1992 , pp. 613 - 615
Copyright
Copyright © JLO (1984) Limited 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Benazzo, M., Pizzala, R. (1985) Biological markers of laryngeal carcinoma. Updating progress. Medecine Biologie Environnement, 13: 241–247.Google Scholar
Dobryszycka, W., Osada, J., Gerber, J., Jabtoriski, K. (1973) Biochemical studies of cancer patients treated with acridine derivative (C-283). Changes in the levels of serum haptoglobin and sialic acid. Archivum Immunologiae et Therapiae Experimentalis (Warz.), 21: 271–279.Google Scholar
Erlanger, B. E, Kokowsky, N., Cochen, W. (1961) The preparation and properties of two new chromogenic substrates of trypsin Archives of Biochemistry and Biophysics, 95: 271–274.Google Scholar
Fish, R. G., Yap, A. K. L., James, K. (1982) Changes in serum acute phase proteins in breast cancer patients receiving methotrexate infusion therapy. Clinical Biochemistry, 15: 4–8.Google Scholar
Henry, J. B. (1979) Clinical diagnosis and management. W. B. Saunders Company: Philadelphia, London, Toronto.Google Scholar
Klein, G., Weinhouse, S. (1979) Advances in cancer research. Vol. 30. Academic Press: New York, San Francisco, London, 42 pp.Google Scholar
Koj, A. (1985) Reakcja ostrej fazy i klasyfikacja bialek ostrej fazy. Diagnostyka Laboratoryjna, 21: 261–269.Google Scholar
Sydov, G. (1985) A simplified quick method for determination of sialic acid in serum. Biomedia Biochimica Acta, 44: 1721–1724.Google Scholar
Warwas, M., Dobryszycka, W., Gerber, J., Pietkiewicz, A. (1981) Clinical usefulness of serum acute-phase reactants in patients with ovarian tumours. Neoplasma, 28: 485–490.Google Scholar