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AIDS-like disproportion of minor T-cell subsets in Japanese patients with Wegener's granulomatosis

Published online by Cambridge University Press:  29 June 2007

Makoto Ikeda ,
Yoshiya Katsura ,
Sumiaki Tsuru ,
Tetsuzo Inouye  and
Gerald B. Healy
Makoto Ikeda*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Saitama, Japan
Yoshiya Katsura
Affiliation:
Department of Microbiology, National Defense Medical College, Saitama, Japan
Sumiaki Tsuru
Affiliation:
Department of Microbiology, National Defense Medical College, Saitama, Japan
Tetsuzo Inouye
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Saitama, Japan
Gerald B. Healy
Affiliation:
Department of Otology and Laryngology, Havard Medical School, Boston, MA.
*
Dr Ikeda, Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, 3–2 Namiki, Tokorozawa, Saitama, Japan.
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Abstract

Fifteen Japanese patients with Wegener's granulomatosis (WG) were evaluated according to their lymphocyte subset abnormalities. Two colour immunofluorescent flow cytometry was used to distinguish the lymphocyte subset alterations. WG group showed a decrease in the percentage of CD4+ cells and the increase of CD8 + cells. Within the NK cell family, the functionally unidentified CD8 +57 + cells were markedly elevated. The disproportion of thelymphocyte subsets (CD4 +↓ CD8 +57 +↑) were similar to those of Acquired Immunodeficiency Syndrome (AIDS) and AIDS relating complexes (ARC). To assesssilent infection of Human immunodeficiency virus (HIV), the polymerase chain reaction (PCR) wasdone for all patients to selectively amplify specific HIV proviral DNA sequences in peripheral blood mononuclear cells, HIV-1 proviral DNA was not found in any patients but these changes of WG might suggest a possible adaptive response to unknown viral infection.

Keywords

Wegener's granulomatosisFlow cytometryViral infectionHuman immunodeficiency virus
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 2 , February 1992 , pp. 133 - 136
Copyright
Copyright © JLO (1984) Limited 1992

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