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An unusual presentation of aggressive epithelial-myoepithelial carcinoma of the nasal cavity with high-grade histology

Published online by Cambridge University Press:  05 September 2011

J-O Park ,
C-K Jung ,
D-I Sun  and
M-S Kim
J-O Park
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea
C-K Jung
Affiliation:
Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea
D-I Sun
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea
M-S Kim*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea
*
Address for correspondence: Dr Min-Sik Kim, Department of Otolaryngology-HNS, 505 Banpodong SeochoguSeoul St Mary's Hospital, The Catholic University of Korea, Seoul, South Korea137-040 Fax: +82 2 595 1354 E-mail: entkms@catholic.ac.kr
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Abstract

Background:

Epithelial-myoepithelial carcinoma is an uncommon, low-grade carcinoma that generally occurs in the salivary glands. A few cases of epithelial-myoepithelial carcinoma arising in the nasal cavity have been reported. We describe a unique case of aggressive epithelial-myoepithelial carcinoma in the nasal cavity.

Case report:

A 36-year-old woman presented with a mass in her left nasal cavity. Histopathological evaluation revealed it to be an epithelial-myoepithelial carcinoma with overt nuclear atypia, frequent mitoses and necrosis. The tumour recurred in the contralateral nasal cavity 15 months following primary excision. Medial maxillectomy and radiation therapy were performed. Seven-month follow up revealed extensive bone metastases.

Conclusion:

We report a rare case of aggressive epithelial-myoepithelial carcinoma in the nasal cavity, with high-grade histology.

Keywords

Myoepithelial TumourCarcinomaNasal CavityMetastasis
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 12 , December 2011 , pp. 1286 - 1289
Copyright
Copyright © JLO (1984) Limited 2011

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References

1Batsakis, JG, Naggar, AK, Luna, MA. Epithelial-myoepithelial carcinoma of salivary glands. Ann Otol Rhinol Laryngol 1992;101:540–2CrossRefGoogle ScholarPubMed
2Horinouchi, H, Ishihara, T, Kawamura, M. Epithelial myoepithelial tumours of the tracheal gland. J Clin Pathol 1993;46:185–7CrossRefGoogle ScholarPubMed
3Ostrowski, ML, Font, RL, Halpern, J, Nicolitz, E, Barnes, R. Clear cell epithelial-myoepithelial carcinoma arising in pleomorphic adenoma of the lacrimal gland. Ophthalmology 1994;101:925–30CrossRefGoogle ScholarPubMed
4Harada, H, Kashiwagi, S, Fujiura, H, Kusukawa, J, Morimatsu, M. Epithelial-myoepithelial carcinoma – report of a case arising in the nasal cavity. J Laryngol Otol 1996;110:397–400CrossRefGoogle ScholarPubMed
5Jin, XL, Ding, CN, Chu, Q. Epithelial-myoepithelial carcinoma arising in the nasal cavity: a case report and review of literature. Pathology 1999;31:148–51CrossRefGoogle ScholarPubMed
6Lee, HM, Kim, AR, Lee, SH. Epithelial-myoepithelial carcinoma of the nasal cavity. Eur Arch Otorhinolaryngol 2000;257:376–8CrossRefGoogle ScholarPubMed
7Yamanegi, K, Uwa, N, Hirokawa, M. Epithelial-myoepithelial carcinoma arising in the nasal cavity. Auris Nasus Larynx 2008;35:408–13CrossRefGoogle ScholarPubMed
8Donath, K, Seifert, G, Schmitz, R. Diagnosis and ultrastructure of the tubular carcinoma of salivary gland ducts. Epithelial-myoepithelial carcinoma of the intercalated ducts [in German]. Virchows Arch A Pathol Pathol Anat 1972;356:16–31CrossRefGoogle ScholarPubMed
9Ellis, GI, Auclair, PL. Malignant epithelial tumours. In: Rosai, J, ed. Tumours of the Salivary Glands. Washington DC: Armed Forces Institute of Pathology, 1996;268–89Google Scholar
10Lau, DP, Goddard, MJ, Bottrill, ID, Moffat, DA. Epithelial-myoepithelial carcinoma of the parotid gland: an unusual cause of ear canal stenosis. J Laryngol Otol 1996;110:493–5CrossRefGoogle ScholarPubMed
11Seethala, RR, Barnes, EL, Hunt, JL. Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumours of the salivary glands and upper aerodigestive tract. Am J Surg Pathol 2007;31:44–57CrossRefGoogle ScholarPubMed
12Ellis, GL, Auclair, PL. Atlas of Tumours of the Salivary Glands, 3rd series, fascile 17. Washington DC: Armed Forces Institute of Pathology, 1996Google Scholar
13Seifert, G, Brocheriou, C, Cardesa, A, Eveson, JW. WHO International histological classification of tumours. Tentative histological classification of salivary gland tumours. Pathol Res Pract 1990;186:555–81CrossRefGoogle ScholarPubMed
14Witterick, IJ, Noyek, AM, Chapnik, JS, Heathcote, JG, Bedard, YC. Observation of the natural history of a parotid epithelial myoepithelial carcinoma of intercalated ducts. J Otolaryngol 1993;22:176–9Google ScholarPubMed
15Lau, DPC, Goddard, MJ, Bottrill, ID, Moffat, DA. Epithelial-myoepithelial carcinoma of the parotid gland. An unusual cause of ear canal stenosis. J Laryngol Otol 1996;110:493–5CrossRefGoogle ScholarPubMed
16Kumagai, M, Suzuki, H, Matsuura, K, Takahashi, E, Hashimoto, S, Suzuki, H, Tezuka, F. Epithelial-myoepithelial carcinoma of the parotid gland. Auris Nasus Larynx 2003;30:201–3CrossRefGoogle ScholarPubMed
17Deere, H, Hore, I, McDermott, N, Levine, T. Epithelial-myoepithelial carcinoma of the parotid gland: a case report and review of the cytological and histological features. J Laryngol Otol 2001;115:434–6CrossRefGoogle ScholarPubMed
18Collina, G, Gale, N, Visona, A, Betts, M, Cenacchi, V, Eusebi, V. Epithelial-myoepithelial carcinoma of the parotid gland: clinic-pathologic and immunohistochemical study of seven cases. Tumouri 1991;77:257–73CrossRefGoogle Scholar
19Corio, R, Sciubba, J, Brannon, R, Batsakis, J. Epithelial-myoepithelial carcinoma of intercalated duct origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1982;53:280–7CrossRefGoogle ScholarPubMed
20Alos, L, Carrillo, R, Ramos, J, Baez, C, Mallofre, P, Fernandez, A. High-grade carcinoma component in epithelial-myoepithelial carcinoma of salivary glands clinicopathological, immunohistochemical and flow-cytometric study of three cases. Virchow Arch 1999;434:291–9CrossRefGoogle ScholarPubMed