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Arterial spin labelling and diffusion-weighted magnetic resonance imaging in differentiation of recurrent head and neck cancer from post-radiation changes

Published online by Cambridge University Press:  02 November 2018

A A K Abdel Razek
A A K Abdel Razek*
Affiliation:
Department of Diagnostic Radiology, Faculty of Medicine, Mansoura University, Egypt
*
Author for correspondence: Dr Ahmed Abdel Khalek Abdel Razek, Department of Diagnostic Radiology, Faculty of Medicine, Mansoura University, Mansoura 13351, Egypt E-mail: arazek@mans.edu.eg Fax: +20 502 315 105
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Abstract

Objective

To assess arterial spin labelling and diffusion-weighted imaging in the differentiation of recurrent head and neck cancer from post-radiation changes.

Methods

A retrospective study was conducted of 47 patients with head and neck cancer, treated with radiotherapy, who underwent magnetic resonance arterial spin labelling and diffusion-weighted magnetic resonance imaging. Tumour blood flow and apparent diffusion co-efficient of the lesion were calculated.

Results

There was significant difference (p = 0.001) in tumour blood flow between patients with recurrent head and neck cancer (n = 31) (47.37 ± 16.3 ml/100 g/minute) and those with post-radiation changes (n = 16) (18.80 ± 2.9 ml/100 g/minute). The thresholds of tumour blood flow and apparent diffusion co-efficient used for differentiating recurrence from post-radiation changes were more than 24.0 ml/100 g/minute and 1.21 × 10−3 mm2/second or less, with area under the curve values of 0.94 and 0.90, and accuracy rates of 88.2 per cent and 88.2 per cent, respectively. The combined tumour blood flow and apparent diffusion co-efficient values used for differentiating recurrence from post-radiation changes had an area under the curve of 0.96 and an accuracy of 90.2 per cent.

Conclusion

Combined tumour blood flow and apparent diffusion co-efficient can differentiate recurrence from post-radiation changes.

Keywords

NeoplasmsRecurrenceRadiotherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 10 , October 2018 , pp. 923 - 928
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr A A K Abdel Razek takes responsibility for the integrity of the content of the paper

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