Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-10T08:14:43.245Z Has data issue: false hasContentIssue false
  • English
  • Français

Auditory brainstem evoked potentials in asymptomatic lead-exposed subjects

Published online by Cambridge University Press:  29 June 2007

Y. Holdstein ,
H. Pratt ,
M. Goldsher ,
G. Rosen ,
R. Shenhav ,
S. Linn ,
A. Mor  and
A. Barkai
Get access Rights & Permissions [Opens in a new window]

Abstract

Auditory Brainstem Evoked Potentials (ABEP) were recorded from 29 adults and children, accidentally exposed to lead through food until approximately a year prior to this study. ABEP were recorded in response to 75 dBHL click presented at rates of 10/sec. and 55/sec. Average values were calculated for peak latency and for interpeak latency differences. Average values of the effect of increasing stimulus rate were calculated as well. Similar values were calculated for normative child and adult control groups.

IPLD (I-III) showed the most significant and recurring results, with longer intervals in lead-exposed children compared with their control group. Increasing stimulus rate, on the other hand, affected the adult lead-exposed subjects more than the children. These results may imply an impairment of the auditory system with azonal and myelin involvement. ABEP is suggested as a sensitive detector of subclinical lead exposure effects on the nervous system.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 100 , Issue 9 , September 1986 , pp. 1031 - 1036
Copyright
Copyright © JLO (1984) Limited 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Berant, M. (1984) Lead over exposure in children. Journal of the Israel Medical Association, 106: 28–31.Google Scholar
Cohen, M. M. (1979) Biochemical aspects of lead neurotoxicity; pp. 6572 in Vinken, B. J. and Bruyn, G. W., Intoxications of the nervous system, part I of Handbook of Clinical Neurology, North Holland Publishing Company, Amsterdam.Google Scholar
Deltenre, P., Vercruisse, A., van Nechel, C., Ketelaer, P., Capon, A., Colin, F. and Manil, J. (1979) Early diagnosis of MS by combined multimodal evoked potentials: Results and practical considerations. Journal of Biomedical Engineering, 1: 17–21.CrossRefGoogle ScholarPubMed
Girardi, G., Cis, C. and Piatti, A. (1967) La sindrome nucleoreticulare cronica nelle intossicasioni professionali. Archives of Italian Otology, 78: 756–770.Google Scholar
Goldsher, M., Pratt, H., Hassan, A., Shenhav, R., Eliachar, I and Kanter, Y. Auditory brainstem evoked potentials in Insulin dependent diabetics with and without peripheral neuropathy. Acta Otolaryngologica, in press.Google Scholar
Graef, J. W. (1979) Clinical aspectsof lead poisoning; pp. 1–34 in Vinken, B. J.and Bruyn, G. W., Intoxications of the nervous system, part I of Handbook of Clinical Neurology, North Holland Publishing Company, Amsterdam.Google Scholar
Hirano, A. and Iwata, M. (1979) Neuropathology of lead intoxication; pp. 35–64 in Vinken, B. J. and Bruyn, G. W., Intoxications of the nervous system, part I of Handbook of Clinical Neurology, North Holland Publishing Company, Amsterdam.Google Scholar
Kjaer, M. (1980) Brainstem auditory and visual evoked potentials in multiple sclerosis. Acta Neurologica Scandinavica, 62: 14–19.CrossRefGoogle ScholarPubMed
Klaasen, C. D. (1980) Heavy metals and heavy metal antagonists; pp. 1616–1620 in Gilman, A. G., Goodman, L. S. and Gilman, A., The Pharmacological Basis of Therapeutics, McMillan Publishing Company Inc., New York.Google Scholar
Moore, E. J. (ed.) (1983) Bases of auditory brainstem evoked responses. Grune and Stratton, New York.Google Scholar
Pratt, H., Ben-David, Y., Peled, R., Podoshin, L. and Scharf, B. (1981) Auditory brainstem evoked potentials: Clinical promise of increasing stimulus rate. Electroencephalography clinical Neurophysiology, 51: 80–90.CrossRefGoogle ScholarPubMed
Pratt, H., Brodsky, G., Goldsher, M., Ben-David, Y., Harari, R., Podoshin, L., Eliachar, I., Grushka, E., Better, O. and Garti, J. (1986) Auditory brainstem evoked potentials in patients undergoing dialysis. Electroencephalography and Clinical Neurophysiology, 63: 18–24.CrossRefGoogle ScholarPubMed
Robinson, K. and Rudge, P. (1975) Auditory evoked responses in multiple sclerosis. Lancet 1: 1164–11666.CrossRefGoogle ScholarPubMed
Robinson, K. and Rudge, P. (1977) Abnormalities of the auditory evoked potentials in patients with MS. Brain, 100: 19–40.CrossRefGoogle Scholar
Thornton, A. R. D., Hawkes, C. A. and Shepherd, D. I. (1978) Cochlear and brainstem responses in MS. Electroencephalography clinical Neurophysiology, 44: 131–132.Google Scholar
Uri, N., Shuchman, G. and Pratt, H. (1984) Auditory brainstem evoked potentials in Bell's palsy. Arcnhives of Otolaryngology, 110: 301–304.CrossRefGoogle ScholarPubMed
Vaziri, D., Pratt, H., Saiki, J. K. and Starr, A. (1981) Evaluation of somatosensory pathway by short latency evoked potentials in patients with end-stage renal disease maintained on hemodialysis. International Journal Artificial Organs, 4: 17–22.Google ScholarPubMed
WHO (1977) Environmental health criteria 3: Lead.Google Scholar
WHO Study Group (1980) Recommended health-based limits in occupational exposure to heavy metals. World Health Organization—Technical Report Series 647.Google Scholar