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The blastic variant of mantle cell lymphoma arising in Waldeyer's tonsillar ring

Published online by Cambridge University Press:  29 June 2007

Nadine S. Ives Aguilera ,
M. Uusafr ,
Bruce M. Wenig  and
Susan L. Abbondanzo
Nadine S. Ives Aguilera*
Affiliation:
Departments of Otolaryngologic, Armed Forces Institute of Pathology, Washington D.C.
M. Uusafr
Affiliation:
Departments of Hematopathology, Armed Forces Institute of Pathology, Washington D.C.
Bruce M. Wenig
Affiliation:
Departments of Endocrine Pathology, Armed Forces Institute of Pathology, Washington D.C.
Susan L. Abbondanzo
Affiliation:
Departments of Hematopathology, Armed Forces Institute of Pathology, Washington D.C.
*
Address for correspondence: Nadine S. Ives Aguilera, M.D., Department of Hematopathology, AFIP, Washington D.C., 20306-6000USA Fax: 202-782-9157 E-mail: aguilena@afip.osd.mil
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Abstract

We present three cases of blastic mantle cell lymphoma with an unusual initial manifestation in Waldeyer's ring with methods for differentiating it from other blastic neoplasms of the head and neck. All cases presented with a feeling of fullness inthe area of the mass. Morphologically, the tumours were blastic with a high mitotic rate (three to nine per high power field). All were B-cell phenotype with coexpression of CD43. In all cases cyclin Dl and bcl-2 were positive and CD23 negative. Blastic mantle cell lymphoma occurring in Waldeyer's tonsillar ring may be mistaken for other high grade haematopoietic neoplasms. Immunohistochemistry and awareness of this type of lymphoma arehelpful in differentiating it from other neoplasms.

Keywords

LymphomaB cell mantleTonsil neoplasmsNasopharyngeal neoplasmsTongue neoplasms
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 10 , October 1998 , pp. 991 - 994
Copyright
Copyright © JLO (1984) Limited 1998

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Footnotes

The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Air Force, Department of the Army, or the Department of Defense.

References

Cheng, A.-L., Su, I.-J., Tien, H.-F., Wang, C-C., Chen, Y.-C., Wang, C.-H. (1994) Characteristics clinicopathologicfeatures of adult B-cell lymphoblastic lymphoma with special emphasis on differential diagnosis with an atypical form of blastic lymphocytic lymphoma of intermediate differentiate origin. Cancer 73: 706–710.3.0.CO;2-U>CrossRefGoogle Scholar
Contos, M. J., Kornstein, M. J., Innes, D. J., Ben-Ezra, J. (1992) The utility of CD2O and CD43 in subclassification of low-grade B-cell lymphoma on paraffin sections. Modern Pathology 5: 631–633.Google Scholar
de Boer, C., Schuuring, E., Dreef, E., Peters, G., Bartek, J., Kluin, P. M., van Krieken, H. J. M. (1995) Cyclin Di protein analysis in the diagnosis of mantle cell lymphoma. Blood 86: 2715–2723.CrossRefGoogle ScholarPubMed
Dorfman, D. M., Shahsafaei, A. (1997) Usefulness of a new marker CD5 antibody for the diagnosis of T-cell and B-cell lymphoproliferative disorders in paraffin sections. Modern Pathology 10: 859–863.Google Scholar
Fraga, M., Lioret, E., Sanchez-verde, L., Orradre, J. L., Campo, E., Bosch, F., Pins, M. A. (1995) Mucosal mantle cell (centrocytic) lymphomas. Histopathology 26: 413–422.CrossRefGoogle ScholarPubMed
Harris, N. L., Jaffe, E. S., Stein, H., Banks, P., Chan, J. K. C., Cleary, M. L., Delsol, G., De Woif-Peeters, C., Falini, B., Gatter, K. C., Grogan, T. M., Isaacson, P. G., Knowles, D. M., Mason, D. Y., Müller-Hermelink, H. -K., Pileni, S. A., Piris, M. A., Ralfkiaer, E., Warnke, R. A. (1994) A revised European-American classification of lymphoid neoplasms: Aproposal from the international lymphoma study group. Blood 84: 1361–1392.CrossRefGoogle Scholar
Kaleem, Z., Wakoff, A. R., Smith, R. P., Hess, J. L. (1996) Blastic transformation of mantle cell lymphoma. Archives of Pathology and Laboratory Medicine 120: 577–580.Google ScholarPubMed
Lardelli, P., Bookman, M. A., Sundeen, J., Longo, D. L., Jaffe, E. S. (1990) Lymphocytic lymphoma of intermediate differentiation. Morphologic and immunophenotypic spectrum and clinical correlations. American Journal of Surgical Pathology 14: 752–763.CrossRefGoogle ScholarPubMed
Menarguez, J., Mollejo, M., Carrión, R., Oliva, H., Bellas, C., Forteza, J., Martin, C., Ruiz-Mancellán, C., Morente, M., Romagosa, V., Cuena, R., Piris, M. A. (1994) Waldeyer ring lymphomas. A clinicopathologic study of 79 cases. Histopathology 24: 13–22.CrossRefGoogle ScholarPubMed
Norton, A. J., Matthews, J., Pappa, V., Shamash, J., Love, S., Rohatinen, A. Z. S., Lister, T. A. (1995) Mantle cell lymphoma: Natural history defined in a serially population over a 20-year period. Annals of Oncology 6: 249–256.CrossRefGoogle Scholar
Oka, K., Ohno, T., Yamaguchi, M., Mahmud, N., Miwa, H., Kenkichi, K., Shiku, H., Shirakawa, S. (1996) PRAD1/cyclin Dl gene overexpression in mantle cell lymphoma. Leukemia Lymphoma 21: 37–42.CrossRefGoogle Scholar
Ott, G., Kalla, J., Ott, M. M., Schryen, B., Katzenberger, T., Müller, J. G., Müller-Hermelink, H. K. (1997) Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones. Blood 8 1421–1429.CrossRefGoogle Scholar
Ott, M. M., Helbing, A., Ott, G., Bartek, J., Fischer, L., Dürr, A., Kreipe, H., Müller-Henmelink, H. K. (1996) Bcl-1 rearrangement and cyclin Dl protein expression in mantle cell lymphoma. Journal of Pathology 179: 238–242.3.0.CO;2-W>CrossRefGoogle Scholar
Ott, M. M., Ott, G., Kuse, R., Ponowski, P., Gunzer, U., Feller, A. C., Müllen-Hermelink, H. K. (1994) The anaplastic variant of centrocytic lymphoma is marked by frequent rearrangements of the Bcl-1 gene and high proliferation indices. Histopathology 24: 329–334.CrossRefGoogle ScholarPubMed
Pittaluga, S., Wlodarska, I., Stul, M. S., Thomas, J., Verhoef, G., Cassiman, J. J., Van Den Berghe, H., De Woif-Peeters, C. (1995) Mantle cell lymphoma: a clinicopathological study of 55 cases. Histopathology 26: 17–24.CrossRefGoogle ScholarPubMed
Pombo De Oliveira, M. S., Jaffe, E. S., Catovsky, D. (1989) Leukaemic phase of mantle zone (intermediate) lymphoma: its characterization in11 cases. Journal of Clinical Pathology 42: 962–972.CrossRefGoogle Scholar
Segal, G. H., Masih, A. S., Fox, A. C., Jorgensen, T., Scott, M., Braylan, R. C. (1995) CD5-expnessing B-cell non-Hodgkin's lymphomas with bcl-1 gene rearrangement have a relatively homogeneous immunophenotype and are associated with an overall poor prognosis. Blood 85: 1570–1579.CrossRefGoogle ScholarPubMed
Soslow, R. A., Zukerbeng, L. R., Harris, N. L., Warnke, R. A. (1997) BCL-1 (PRAD-1/CyclinDl) ovenexpression distinguishes the blastoid variant of mantle cell lymphoma from B-lineage lymphoblastic lymphoma. Modern Pathology 10: 810–817.Google Scholar
Swerdlow, S. H., Yang, W. -I., Zukenberg, L. R., Harris, N. L., Arnold, A., Williams, M. E. (1995) Expression of cyclin Dl protein in centrocytic/mantle cell lymphomas with and without rearrangement of the BCL1/cyclin Dl gene. Human Pathology 26: 999–1004.CrossRefGoogle Scholar
Swerdlow, S. H., Zukerberg, L. R., Yang, W. -I., Harris, N. L., Williams, M. E. (1996) The morphologic spectrum of non- Hodgkin's lymphomas with BCL1/cyclin Dl gene rearrangements. American Journal of Surgical Pathology 20: 627–640.CrossRefGoogle Scholar
Vadlamudi, G., Lionetti, K. A., Greenberg, S., Mehta, K. (1996) Leukemic phase of mantle cell lymphoma. Two case reports and reviewof the literature. Archives of Pathology and Laboratory Medicine 120: 35–40.Google Scholar
Weisenburger, D. D., Armitage, J. O. (1996) Mantle cell lymphoma–an entity comes of age. Blood 87: 4483–4494.CrossRefGoogle Scholar
Zoldan, M. C., Inghirami, G., Masuda, Y., Vandekerckhove, F., Raphael, B., Amorosi, E., Hymes, K., Fnizzera, G. (1996) Large-cell variants of mantle cell lymphoma: cytologic characteristics and p53 anomalies may predict poor outcome. British Journal of Haematology 93: 475–486.CrossRefGoogle ScholarPubMed