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Carboplatin ototoxicity: an animal model

Published online by Cambridge University Press:  29 June 2007

Mark Wake ,
Sachio Takeno ,
Danyl Ibrahim ,
Robert Harrison  and
Richard Mount
Mark Wake*
Affiliation:
Department of Otolaryngology and Auditory Science Laboratory, Toronto.
Sachio Takeno
Affiliation:
Department of Otolaryngology and Auditory Science Laboratory, Toronto.
Danyl Ibrahim
Affiliation:
Department of Otolaryngology and Auditory Science Laboratory, Toronto.
Robert Harrison
Affiliation:
Department of Otolaryngology and Auditory Science Laboratory, Toronto.
Richard Mount
Affiliation:
Department of Otolaryngology and Auditory Science Laboratory, Toronto.
*
M. Wake, F.R.C.S., Department of Otolaryngology, Sunnybrook Health Science Centre, Suite #A208, 2075 Bayview Avenue, Toronto, Ontario M4N 3HT, Canada. Fax: (0101)416 480 6830.
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Abstract

A new animal model of ototoxicity is presented using intravenous carboplatin in adult chinchillas. A range of physiological and morphological effects was produced using doses calculated from the recommended therapeutic range (200–400 mg/m2). Auditory thresholds to tone pips stimuli were monitored using brain stem evoked responses (ABR). Cochlear histopathology was studied by light microscopy (LM) and ultrstructural hair cell abnormalities investigated with scanning electronmicroscopy (SEM). Carboplatin in this animal model predominantly affected the inner hair cells. This may provide an important model for the study of selective loss of the main afferent input in the auditory system.

Keywords

CarboplatinOtotoxicityAnimal laboratoryHair cellsMicroscopy, electron
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 7 , July 1993 , pp. 585 - 589
Copyright
Copyright © JLO (1984) Limited 1993

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