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Cisplatin in children: hearing loss correlates with iris and skin pigmentation

Published online by Cambridge University Press:  29 June 2007

N. Wendell Todd ,
Carlos S. Alvarado  and
Debra B. Brewer
N. Wendell Todd*
Affiliation:
Departments of Surgery (Otolaryngology), Emory University School of Medicine, Atlanta. Department of Pediatrics, Emory University School of Medicine, Atlanta.
Carlos S. Alvarado
Affiliation:
Department of Pediatrics, Emory University School of Medicine, Atlanta.
Debra B. Brewer
Affiliation:
The Section of Otolaryngology, Emory Clinic, Atlanta, Georgia, USA.
*
Dr N. Wendell Todd, Department of Surgery (Otolaryngology), Emory University School of Medicine, 1365 Clifton Road NE, Atlanta, Georgia 30322, USA. Fax: 404 778 4295
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Abstract

Pigmentation is reported to affect cisplatin-induced ototoxicity in adult humans. The hearing loss is worse in people with brown irises, than in those with blue irises. We assessed the hypothesis that cisplatintreated children with dark irises suffer more deterioration in auditory thresholds than do those with less pigmentation. For the 19 children whose data met the requirements of this observational retrospective study, we found a weak correlation (Spearman's r = 0.50; p>0.05) of high frequency hearing loss (at 4000 Hz) and pigmentation. Blue or hazel-eyed children averaged 2.9 dB worsening at 4000 Hz, in contrast to 14.2 dB worsening for brown or black-eyed children.

Pigmentation may account for some of the individual susceptibility to cisplatin ototoxicity. We suggest that iris colour be included in future reports of cisplatin-related hearing loss

Keywords

CisplatinOtotoxicityChild
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 10 , October 1995 , pp. 926 - 929
Copyright
Copyright © JLO (1984) Limited 1995

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