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Clear cell carcinoma arising in a pleomorphic adenoma of the submandibular gland

Published online by Cambridge University Press:  29 June 2007

Michael Cassidy  and
Charles E. Connolly
Michael Cassidy*
Affiliation:
Department of Pathology, Royal College of Surgeons in Ireland
Charles E. Connolly
Affiliation:
Department of Histopathology and Cytology, University College Hospital, Galway, Ireland.
*
Dr Michael Cassidy, Department of Pathology, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland. Fax: 01-4780200
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Abstract

Clear cell carcinoma of salivary gland is a rare neoplasm. We report a third case of clear cell carcinoma arising in a pleomorphic adenoma and also in an extraparotid location. We document the immunohistochemical profile of the tumour including reactivity with a marker for the c-erbh-2 oncoprotein and suggest a myoepithelial origin for these lesions. The presence of a tetraploid stemline may account for the rapid tumour progression in this case.

Keywords

Salivary gland neoplasmsCarcinoma, clear cellPloidies
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 6 , June 1994 , pp. 529 - 532
Copyright
Copyright © JLO (1984) Limited 1994

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