Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-10T11:09:17.613Z Has data issue: false hasContentIssue false
  • English
  • Français

Clinical outcomes of adenoid cystic carcinoma of the head and neck: a single institution 20-year experience

Published online by Cambridge University Press:  08 June 2016

S Ali ,
J C-L Yeo ,
T Magos ,
M Dickson  and
E Junor
S Ali
Affiliation:
Department of Otolaryngology and Head & Neck Surgery, St. John's Hospital, Livingston, Scotland, UK
J C-L Yeo*
Affiliation:
Department of Otolaryngology and Head & Neck Surgery, St. John's Hospital, Livingston, Scotland, UK
T Magos
Affiliation:
Department of Otolaryngology and Head & Neck Surgery, St. John's Hospital, Livingston, Scotland, UK
M Dickson
Affiliation:
Department of Otolaryngology and Head & Neck Surgery, St. John's Hospital, Livingston, Scotland, UK
E Junor
Affiliation:
Department of Clinical Oncology, Edinburgh Cancer Centre, Western General Hospital, Edinburgh, Scotland, UK
*
Address for correspondence: Mr J C-L Yeo, Department of Otolaryngology and Head & Neck Surgery, St. John's Hospital, Livingston EH54 6PP, Scotland, UK Fax: +44 131 536 9009 E-mail: j_yeo@doctors.net.uk
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

This study reports the clinical outcomes of head and neck adenoid cystic carcinoma treatment over a 20-year period.

Methods:

The treatment outcome of 51 head and neck adenoid cystic carcinoma patients treated between 1992 and 2013 were analysed. Patients were stratified into radical treatment and disease control groups.

Results:

A total of 40 patients underwent surgery and post-operative radiotherapy. The 10-year disease-specific survival rate was 93 per cent. Eleven patients had tumour recurrence: of these, nine were pulmonary metastases. The 11 patients in the disease control group had a median follow up of 21 months (range, 2–172 months); 5 underwent radical radiotherapy with palliative intent.

Conclusion:

There was late tumour recurrence in over 25 per cent of patients. Adenoid cystic carcinoma has a high tendency to relapse even after radical excision and adjuvant therapy. However, definitive radiotherapy should still be considered on an individual basis because it may provide local control and prolong patient survival.

Keywords

CarcinomaAdenoid CysticHead and Neck NeoplasmsOutcome AssessmentSurvival
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 7 , July 2016 , pp. 680 - 685
Copyright
Copyright © JLO (1984) Limited 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Bhayani, MK, Yener, M, El-Naggar, A, Garden, A, Hanna, EY, Weber, RS et al. Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands. Cancer 2012;118:2872–8CrossRefGoogle ScholarPubMed
2Sung, MW, Kim, KH, Kim, JW, Min, YG, Seong, WJ, Rok, JL et al. Clinicopathologic predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 2003;129:1193–7CrossRefGoogle ScholarPubMed
3Batsakis, JG, Luna, MA, El-Naggar, AK.Histopathologic grading of salivary gland neoplasms: III. Adenoid cystic carcinomas. Ann Otol Rhinol Laryngol 1990;99:1007–9CrossRefGoogle ScholarPubMed
4Amit, M, Binenbaum, Y, Sharma, K, Ramer, N, Ramer, I, Agbetoba, A et al. Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: a meta-analysis. J Neurol Surg B Skull Base 2013;74:118–25CrossRefGoogle ScholarPubMed
5Amit, M, Binenbaum, Y, Sharma, K, Ramer, N, Ramer, I, Agbetoba, A et al. Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study. Head Neck 2014;36:998–1004CrossRefGoogle ScholarPubMed
6van Weert, S, Bloemena, E, van der Waal, I, de Bree, R, Rietveld, DH, Kuik, JD et al. Adenoid cystic carcinoma of the head and neck: a single-center analysis of 105 consecutive cases over a 30-year period. Oral Oncol 2013;49:824–9CrossRefGoogle Scholar
7Michel, G, Joubert, M, Delemazure, AS, Espitalier, F, Durand, N, Malard, O.Adenoid cystic carcinoma of the paranasal sinuses: retrospective series and review of the literature. Eur Ann Otorhinolaryngol Head Neck Dis 2013;130:257–62CrossRefGoogle ScholarPubMed
8Ellington, CL, Goodman, M, Kono, SA, Grist, W, Wadsworth, T, Chen, AY et al. Adenoid cystic carcinoma of the head and neck: Incidence and survival trends based on 1973–2007 Surveillance, Epidemiology, and End Results data. Cancer 2012;118:4444–51CrossRefGoogle ScholarPubMed
9Lloyd, S, Yu, JB, Wilson, LD, Decker, RH.Determinants and patterns of survival in adenoid cystic carcinoma of the head and neck, including an analysis of adjuvant radiation therapy. Am J Clin Oncol 2011;34:76–81CrossRefGoogle ScholarPubMed
10Sanghvi, S, Patel, NR, Patel, CR, Kalyoussef, E, Baredes, S, Eloy, JA.Sinonasal adenoid cystic carcinoma: comprehensive analysis of incidence and survival from 1973 to 2009. Laryngoscope 2013;123:1592–7CrossRefGoogle ScholarPubMed
11Lupinetti, AD, Roberts, DB, Williams, MD, Kupferman, ME, Rosenthal, DI, Demonte, F et al. Sinonasal adenoid cystic carcinoma: the M. D. Anderson Cancer Center experience. Cancer 2007;110:2726–31CrossRefGoogle Scholar
12Khan, AJ, DiGiovanna, MP, Ross, DA, Sasaki, CT, Carter, D, Son, YH et al. Adenoid cystic carcinoma: a retrospective clinical review. Int J Cancer 2001;96:149–58CrossRefGoogle ScholarPubMed
13Duberge, T, Benezery, K, Resbeut, M, Azria, D, Minsat, M, Ellis, S et al. Adenoid cystic carcinoma of the head and neck: a retrospective series of 169 cases. Cancer Radiother 2012;16:247–56Google ScholarPubMed
14Wang, JF, Ge, MH, Wang, KJ, Tan, Z, Chen, C, Xu, JJ.Clinical analysis of 52 cases of adenoid cystic carcinoma in minor salivary gland [in Chinese]. Zhonghua Kou Qiang Yi Xue Za Zhi 2012;47:705–10Google ScholarPubMed
15Liu, D, Labow, DM, Dang, N, Martini, N, Bains, M, Burt, M et al. Pulmonary metastasectomy for head and neck cancers. Ann Surg Oncol 1999;6:572–8CrossRefGoogle ScholarPubMed
16Spiro, RH.Distant metastasis in adenoid cystic carcinoma of salivary origin. Am J Surg 1997;174:495–8CrossRefGoogle ScholarPubMed
17Iseli, TA, Karnell, LH, Graham, SM, Funk, GF, Buatti, JM, Gupta, AK et al. Role of radiotherapy in adenoid cystic carcinoma of the head and neck. J Laryngol Otol 2009;123:1137–44CrossRefGoogle ScholarPubMed
18Terhaard, CH, Lubsen, H, Van der Tweel, I, Hilgers, FJ, Eijkenboom, WM, Marres, HA et al. Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group. Head Neck 2004;26:681–92, 692–3CrossRefGoogle ScholarPubMed
19Mendenhall, WM, Morris, CG, Amdur, RJ, Werning, JW, Hinerman, RW, Villaret, DB.Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck. Head Neck 2004;26:154–62CrossRefGoogle ScholarPubMed
20Gomez, DR, Hoppe, BS, Wolden, SL, Zhung, JE, Patel, SG, Kraus, DH et al. Outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: a recent experience. Int J Radiat Oncol Biol Phys 2008;70:1365–72CrossRefGoogle ScholarPubMed
21Garden, AS, Weber, RS, Morrison, WH, Ang, KK, Peters, LJ.The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation. Int J Radiat Oncol Biol Phys 1995;32:619–26CrossRefGoogle ScholarPubMed
22Silverman, DA, Carlson, TP, Khuntia, D, Bergstrom, RT, Saxton, J, Esclamado, RM.Role for postoperative radiation therapy in adenoid cystic carcinoma of the head and neck. Laryngoscope 2004;114:1194–9CrossRefGoogle ScholarPubMed
23Douglas, JG, Laramore, GE, Austin-Seymour, M, Koh, W, Stelzer, K, Griffin, TW.Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy. Int J Radiat Oncol Biol Phys 2000;46:551–7CrossRefGoogle ScholarPubMed
24Huber, PE, Debus, J, Latz, D, Zierhut, D, Bischof, M, Wannenmacher, M et al. Radiotherapy for advanced adenoid cystic carcinoma: neutrons, photons or mixed beam? Radiother Oncol 2001;59:161–7CrossRefGoogle ScholarPubMed