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Cluster of differentiation 8 T-cell population in the laryngeal mucosa of smokers with laryngeal cancer

Published online by Cambridge University Press:  24 January 2019

S Elwany ,
S Radi ,
H Khalil ,
I Talaat  and
K Belasy
S Elwany*
Affiliation:
Department of Otolaryngology, Alexandria Faculty of Medicine, Egypt
S Radi
Affiliation:
Department of Histology, Alexandria Faculty of Medicine, Egypt
H Khalil
Affiliation:
Department of Otolaryngology, Peninsula School of Medicine, Derriford Hospital, Plymouth, UK
I Talaat
Affiliation:
Department of Pathology, Alexandria Faculty of Medicine, Egypt Department of Clinical Sciences, Sharjah University, Sharjah, UAE
K Belasy
Affiliation:
Department of Otolaryngology, Cairo Police Hospital, Egypt
*
Author for correspondence: Dr Samy Elwany, Department of Otolaryngology, Alexandria Faculty of Medicine, Alexandria, Egypt E-mail: samy.elwany@alexmed.edu.eg
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Abstract

Objective

To study the cluster of differentiation 8 population in the laryngeal mucosa of patients with laryngeal carcinoma. To our knowledge this is the first paper to address this issue.

Methods

The study group included 40 patients with known laryngeal cancer who were scheduled for laryngectomy. The control groups included 10 smokers and 10 non-smokers who were scheduled for microlaryngeal surgery. Specimens from the three groups were processed for histopathological and histochemical evaluation.

Results

In patients without cancer of the larynx, the number of cluster of differentiation 8 lymphocytes was greater in smokers than non-smokers. The number of cluster of differentiation 8 lymphocytes was greatest in smokers with laryngeal cancer, and the difference between this group and the two control groups was statistically significant.

Conclusion

The study showed that smoking increased the number of cluster of differentiation 8 T-lymphocytes in the laryngeal mucosa. The increase was greatest in patients who had developed laryngeal cancer.

Keywords

LarynxCD8 AntigensT-LymphocytesSmokingTobaccoCarcinoma
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 12 , December 2018 , pp. 1134 - 1137
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr S Elwany takes responsibility for the integrity of the content of the paper

References

1Vainio, H, Weiderpass, E, Kleihues, P. Smoking cessation in cancer prevention. Toxicology 2001;166:47–52Google Scholar
2World Health Organization. The World Health Report 2002: Reducing Risks, Promoting Healthy Life. Geneva: World Health Organization, 2002Google Scholar
3International Agency for Research on Cancer. Tobacco habits other than smoking: betel quid and areca nut chewing and some related nitrosamines. IARC Working Group. Lyon, 23-30 October 1984. IARC Monogr Eval Carcinog Risk Chem Hum 1985;37:1–268Google Scholar
4Leong, A, Cooper, K, Leong, F. Manual of Diagnostic Cytology, 2nd edn. Cambridge: Greenwich Medical Media, 2003Google Scholar
5Rees, LE, Jones, P, Ayoub, O, Gunasekaran, S, Rajkumar, K, Stokes, CR et al. Smoking influences the immunological architecture of the human larynx. Clin Immunol 2006;118:342–7Google Scholar
6Barker, E, Haverson, K, Stokes, CR, Birchall, M, Bailey, M. The larynx as an immunological organ: immunological architecture in the pig as a large animal model. Clin Exp Immunol 2006;143:6–14Google Scholar
7Jang, M, Kim, HJ, Chung, Y, Lee, Y, Park, S. A comparison of Ki-67 counting methods in luminal breast cancer: the average method vs. the hot spot method. PLoS One 2017;12:e0172031Google Scholar
8Jecker, P, Ptok, M, Pabst, R, Westermann, J. Distribution of immunocompetent cells in various areas in the normal laryngeal mucosa of the rat. Euro Arch Otorhinolaryngol 1996;253:142–6Google Scholar
9Debertin, AS, Tschernig, T, Schürmann, A, Bajanowski, T, Brinkmann, B, Pabst, R. Coincidence of different structures of mucosa-associated lymphoid tissue (MALT) in the respiratory tract of children: no indications for enhanced mucosal immunostimulation in sudden infant death syndrome (SIDS). Clin Exp Immunol 2006;146:54–9Google Scholar
10Hoesli, R, Birkeland, AC, Rosko, AJ, Issa, M, Chow, KL, Michmerhuizen, N et al. Proportion of CD4 and CD8 tumor infiltrating lymphocytes predicts survival in persistent/recurrent laryngeal squamous cell carcinoma. Oral Oncol 2018;77:83–9Google Scholar
11Karpathiou, G, Casteillo, F, Giroult, JB, Forest, F, Fournel, P, Monaya, A et al. Prognostic impact of immune microenvironment in laryngeal and pharyngeal squamous cell carcinoma: immune cell subtypes, immuno-suppressive pathways and clinicopathologic characteristics. Oncotarget 2017;8:19310–22Google Scholar
12Rosenberg, SA, Restifo, NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science 2015;348:62–8Google Scholar
13Dewyer, NA, Wolf, GT, Light, E, Worden, F, Urba, S, Eisbruch, A et al. Circulating CD4-positive lymphocyte levels as predictor of response to induction chemotherapy in patients with advanced laryngeal cancer. Head Neck 2014;36:9–14Google Scholar
14Waldmann, TA. Immunotherapy: past, present and future. Nat Med 2003;9:269–77Google Scholar