Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-10T12:24:47.112Z Has data issue: false hasContentIssue false
  • English
  • Français

Comparison of nasal cytology and symptom scores in patients with seasonal allergic rhinitis, before and after treatment

Published online by Cambridge University Press:  27 July 2011

A Özgür ,
S Arslanoğlu ,
D Etıt ,
U Demıray  and
H K Önal
A Özgür
Affiliation:
Department of Otorhinolaryngology, İzmir Atatürk Training and Research Hospital, Turkey
S Arslanoğlu*
Affiliation:
Department of Otorhinolaryngology, İzmir Atatürk Training and Research Hospital, Turkey
D Etıt
Affiliation:
Department of Pathology, İzmir Atatürk Training and Research Hospital, Turkey
U Demıray
Affiliation:
Department of Otorhinolaryngology, İzmir Atatürk Training and Research Hospital, Turkey
H K Önal
Affiliation:
Department of Otorhinolaryngology, İzmir Atatürk Training and Research Hospital, Turkey
*
Address for correspondence: Dr Seçil Arslanoğlu, İnönü Cad No 556/3, 35290 İzmir, Turkey Fax:  +90232 243 15 30 E-mail: secilarslanoglu@hotmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To evaluate symptom scores and nasal smear cytology findings in seasonal allergic rhinitis patients, before and after treatment.

Methods:

Twenty-nine consecutive adult patients with seasonal allergic rhinitis were evaluated prospectively. They received mometasone furoate nasal spray and cetirizine for 21 days. Nasal and ocular symptom scores were recorded before and after treatment. Nasal cytology was also assessed as a means of determining treatment.

Results:

The combined use of an intranasal corticosteroid and an oral antihistamine caused a significant improvement in nasal and ocular symptom scores. Cytological evaluation revealed significant reduction in nasal eosinophil, neutrophil and goblet cell counts after three weeks' treatment.

Conclusion:

Symptom scoring systems are widely used for the evaluation of drug efficacy in allergic rhinitis treatment. When investigating the disease and evaluating treatment efficacy, objective as well as subjective methods are needed. Nasal cytological assessment is a simple, objective method which provides valuable information about the nasal mucosa.

Keywords

RhinitisPathologyCell BiologySymptoms And Signs
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 10 , October 2011 , pp. 1028 - 1032
Copyright
Copyright © JLO (1984) Limited 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Stuck, BA, Czajkowski, J, Hagner, AE, Klimek, L, Verse, T, Hörmann, K et al. Changes in daytime sleepiness, quality of life, and objective sleep patterns in seasonal allergic rhinitis: a controlled clinical trial. J Allergy Clin Immunol 2004;113:663–8CrossRefGoogle ScholarPubMed
2Leynaert, B, Neukirch, C, Liard, R, Bousquet, J, Neukirch, F. Quality of life in allergic rhinitis and asthma. A population-based study of young adults. Am J Respir Crit Care Med 2000;162:1391–6CrossRefGoogle ScholarPubMed
3Bauchau, V, Durham, SR. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J 2004;24:758–64CrossRefGoogle ScholarPubMed
4Howarth, PH, Persson, CG, Meltzer, EO, Jacobson, MR, Durham, SR, Silkoff, PE. Objective monitoring of nasal airway inflammation in rhinitis. J Allergy Clin Immunol 2005;115:414–41CrossRefGoogle ScholarPubMed
5Akerlund, A, Andersson, M, Leflein, J, Lildholdt, T, Mygind, N. Clinical trial design, nasal allergen challenge models, and considerations of relevance to pediatrics, nasal polyposis, and different classes of medication. J Allergy Clin Immunol 2005;115:460–82CrossRefGoogle ScholarPubMed
6Okuda, M. Grading the severity of allergic rhinitis for treatment strategy and drug study purposes. Curr Allergy Asthma Rep 2001;1:235–41CrossRefGoogle ScholarPubMed
7Meltzer, EO, Jalowayski, AA, Orgel, HA, Harris, AG. Subjective and objective assessments in patients with seasonal allergic rhinitis: effects of therapy with mometasone furoate nasal spray. J Allergy Clin Immunol 1998;102:39–49CrossRefGoogle ScholarPubMed
8Bousquet, J, Van Cauwenberge, P, Khaltaev, N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001;108:147–334CrossRefGoogle ScholarPubMed
9Gelardi, M, Fiorella, ML, Russo, C, Fiorella, R, Ciprandi, G. Role of nasal cytology. Int J Immunopathol Pharmacol 2010;23:45–9CrossRefGoogle ScholarPubMed
10Gelardi, M, Russo, C, Fiorella, ML, Fiorella, R, Canonica, GW, Passalacqua, G. When allergic rhinitis is not only allergic. Am J Rhinol Allergy 2009;23:312–15CrossRefGoogle Scholar
11Settipane, RA. Rhinitis: a dose of epidemiological reality. Allergy Asthma Proc 2003;24:147–54Google ScholarPubMed
12Bousquet, J, Khaltaev, N, Cruz, AA, Denburg, J, Fokkens, WJ, Togias, A et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008. Allergy 2008;63:8–160CrossRefGoogle ScholarPubMed
13Potter, PC. Levocetirizine is effective for symptom relief including nasal congestion in adolescent and adult (PAR) sensitized to house dust mites. Allergy 2003;58:893–9CrossRefGoogle ScholarPubMed
14Lee, CF, Sun, HL, Lu, KH, Ku, MS, Lue, KH. The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis. Pediatr Allergy Immunol 2009;20:493–9CrossRefGoogle ScholarPubMed
15Bielory, L. Ocular symptom reduction in patients with seasonal allergic rhinitis treated with the intranasal corticosteroid mometasone furoate. Ann Allergy Asthma Immunol 2008;100:272–9CrossRefGoogle ScholarPubMed
16Origlieri, C, Bielory, L. Intranasal corticosteroids and allergic rhinoconjunctivitis. Curr Opin Allergy Clin Immunol 2008;8:450–6CrossRefGoogle ScholarPubMed
17Anolik, R, Pearlman, D, Teper, A, Gates, D. Mometasone furoate improves nasal and ocular symptoms of seasonal allergic rhinitis in adolescents. Allergy Asthma Proc 2009;30:406–12CrossRefGoogle ScholarPubMed
18Meltzer, EO, Orgel, HA, Rogenes, PR, Field, EA. Nasal cytology in patients with allergic rhinitis: effects of intranasal fluticasone propionate. J Allergy Clin Immunol 1994;94:708–15CrossRefGoogle ScholarPubMed
19Meltzer, EO, Orgel, HA, Bronsky, EA, Furukawa, CT, Grossman, J, LaForce, CF et al. A dose-ranging study of fluticasone propionate aqueous nasal spray for seasonal allergic rhinitis assessed by symptoms, rhinomanometry, and nasal cytology. J Allergy Clin Immunol 1990;86:221–30CrossRefGoogle ScholarPubMed
20Ciprandi, G, Cirillo, I, Vizzaccaro, A, Civardi, E, Barberi, S, Allen, M et al. Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study. Int Immunopharmacol 2005;5:1800–8CrossRefGoogle ScholarPubMed
21Ciprandi, G, Tosca, MA, Passalacqua, G, Canonica, GW. Intranasal mometasone furoate reduces late-phase inflammation after allergen challenge. Ann Allergy Asthma Immunol 2001;86:433–8CrossRefGoogle ScholarPubMed
22Lim, MC, Taylor, RM, Naclerio, RM. The histology of allergic rhinitis and its comparison to cellular changes in nasal lavage. Am J Respir Crit Care Med 1995;151:136–44CrossRefGoogle ScholarPubMed
23Yamasaki, ML, Sasaki, K, Mizutani, N, Nabe, T, Sakura, Y, Matsumoto, T et al. Pharmacological characterization of the leukocyte kinetics after intranasal antigen challenge in a guinea pig model of allergic rhinitis. Inflamm Res 2001;50:474–82CrossRefGoogle Scholar
24Borres, MP, Irander, K, Björkstén, B. Metachromatic cells in nasal mucosa after allergen challenge. Allergy 1990;45:98–103CrossRefGoogle ScholarPubMed
25Saito, H, Howie, K, Wattie, J, Denburg, A, Ellis, R, Inman, MD et al. Allergen-induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhinitis. Immunology 2001;104:226–34CrossRefGoogle ScholarPubMed
26Nakaya, M, Dohi, M, Okunishi, K, Nakagome, K, Tanaka, R, Imamura, M et al. Prolonged allergen challenge in murine nasal allergic rhinitis: nasal airway remodeling and adaptation of nasal airway responsiveness. Laryngoscope 2007;117:881–5CrossRefGoogle ScholarPubMed
27Berger, G, Moroz, A, Marom, Z, Ophir, D. Inferior turbinate goblet cell secretion in patients with perennial allergic and nonallergic rhinitis. Am J Rhinol 1999;13:473–7CrossRefGoogle ScholarPubMed